The Registry of Toxic Effects of Chemical Substances

1,3 - Cyclopentadiene, 1,2,3,4,5,5 - hexachloro -

RTECS #: GY1225000

CAS #: 77-47-4

UPDATE: February 2005 MW: 272.75 MF: C5Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. C - 56
  2. Graphlox
  3. Hexachlorcyklopentadien (Czech)
  4. Hexachlorocyclopentadiene
  5. Hexachlorocyclopentadiene (ACGIH)
  6. Hexachloro - 1,3 - cyclopentadiene
  1. 1,2,3,4,5,5 - Hexachloro - 1,3 - cyclopentadiene
  2. HRS 1655
  3. NCI - C55607
  4. Perchlorocyclopentadiene
  5. RCRA waste number U130


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,149,1986
eye
rabbit 		100 mg/5 minute severe VELPB* #50101-2,1976
skin
guinea pig 		20 mg mild AMIHAB 11,459,1955
skin
monkey 		10 mg severe AMIHAB 11,459,1955
skin
rabbit 		500 mg/4 hour severe VELPB* #50101-2,1976
skin
rabbit 		500 µL/24 hour severe NTIS** OTS0537036


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 975 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 53,497,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 84 mg/m3/7 hour N/R VCVGH* -,551,1990
inhalation
dog 		lowest published lethal concentration: 840 mg/m3/30 minute N/R VCVGH* -,551,1990
inhalation
guinea pig 		lowest published lethal concentration: 3,200 ppb/7 hour N/R AMIHAB 11,459,1955
inhalation
guinea pig 		lowest published lethal concentration: 139 mg/m3/3 hour N/R VCVGH* -,551,1990
inhalation
mouse 		lowest published lethal concentration: 1,500 ppb/7 hour N/R TXAPA9 53,497,1980
inhalation
mouse 		lowest published lethal concentration: 139 mg/m3/3 hour N/R VCVGH* -,551,1990
inhalation
rat 		lethal concentration (50 percent kill): 1,600 ppb/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		JTEHD6 9,743,1982
inhalation
rat 		lowest published lethal concentration: 139 mg/m3/3 hour N/R VCVGH* -,551,1990
inhalation
rat 		lethal concentration (50 percent kill): 23 mg/m3/2 hour N/R VCVGH* -,551,1990
inhalation
rabbit 		lowest published lethal concentration: 1,500 ppb/7 hour N/R TXAPA9 53,497,1980
inhalation
rabbit 		lowest published lethal concentration: 139 mg/m3/3 hour N/R VCVGH* -,551,1990
oral
mouse 		lethal dose (50 percent kill): 505 mg/kg N/R JAFCAU 23,967,1975
oral
rat 		lethal dose (50 percent kill): 200 mg/kg N/R VCVGH* -,552,1990
oral
rabbit 		lowest published lethal dose: 420 mg/kg N/R PCOC** -,586,1966
skin
rabbit 		lethal dose (50 percent kill): 430 mg/kg N/R 34ZIAG -,308,1969
skin
rabbit 		lowest published lethal dose: 300 mg/kg N/R VCVGH* -,552,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 340 ppb/7 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AMIHAB 11,459,1955
inhalation
mouse 		lowest published toxic concentration: 150 ppb/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 6,57,1986
inhalation
mouse 		lowest published toxic concentration: 340 ppb/7 hour/6 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 11,459,1955
inhalation
rat 		lowest published toxic concentration: 100 ppb/6 hour/30 week- intermittent Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0539137
inhalation
rat 		lowest published toxic concentration: 500 ppb/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHD6 9,743,1982
inhalation
rat 		lowest published toxic concentration: 400 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight 		NTPTR* NTP-TR-437,1994
inhalation
rabbit 		lowest published toxic concentration: 340 ppb/7 hour/6 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 11,459,1955
oral
mouse 		lowest published toxic dose: 2,470 mg/kg/13 week- intermittent Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		JJATDK 4,75,1984
oral
rat 		lowest published toxic dose: 2,470 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JJATDK 4,75,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 001 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 ppm (0.11 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (1 mg/m3), short term exposure limit 0.3 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.01 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.01 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXACHLOROCYCLOPENTADIENE-air 10 hour time-weighted average 0.01 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0175;
Number of Industries 2;
Total Number of Facilities 61;
Number of Occupations 14;
Total Number of Employees Exposed 1,427


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166670)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used to produce the flame retardant CHLORENDIC ANHYDRIDE and CHLORENIC ACID
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hexachloro-1,3-cyclopentadiene, 2518
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NTP Carcinogenesis studies (inhalation);no evidence:rat NTPTR* NTP-TR-437,1994


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
VELPB* Velsicol Chemical Corp., Product Bulletin. (341 E. Ohio St., Chicago, IL 60611)

Used to produce the flame retardant CHLORENDIC ANHYDRIDE and CHLORENIC ACID

NIOSH PROFILE (CYCLOPENTADIENES), SRC, 12/79

NIOSH PROFILE (HEXACHLOROBUTADIENE), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector
   Primary Irritant

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