RTECS:GY1000000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

1,3 - Cyclopentadiene

RTECS #: GY1000000

CAS #: 542-92-7

UPDATE: November 2004 MW: 66.11 MF: C₅H₆

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Cyclopentadiene

Cyclopentadiene (ACGIH:OSHA)

Pentole

Pyropentylene

R - Pentine

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 35 mg/m³ Behavioral: Headache VCVGH* -,91,1990
inhalation
human lowest published toxic concentration: 360 mg/m³ Lung, Thorax, or Respiration: Dyspnea VCVGH* -,91,1990
inhalation
mouse lethal concentration (50 percent kill): 14 gm/m³ Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression GTPZAB 9(12),13,1965
inhalation
mouse lowest published toxic concentration: 15,000 mg/m³ Behavioral: General anesthetic VCVGH* -,91,1990
inhalation
mouse lethal concentration (16 percent kill): 9,200 mg/m³ N/R VCVGH* -,91,1990
inhalation
mouse lethal concentration (50 percent kill): 11,600 mg/m³ N/R VCVGH* -,91,1990
inhalation
mouse lethal concentration (84 percent kill): 17,000 mg/m³ N/R VCVGH* -,91,1990
inhalation
rat lethal concentration (50 percent kill): 39 gm/m³ Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression GTPZAB 9(12),13,1965
inhalation
rat lowest published toxic concentration: 60,000 mg/m³ Behavioral: General anesthetic VCVGH* -,91,1990
inhalation
rat lethal concentration (16 percent kill): 29,000 mg/m³ N/R VCVGH* -,91,1990
inhalation
rat lethal concentration (50 percent kill): 35,900 mg/m³ N/R VCVGH* -,91,1990
inhalation
rat lethal concentration (84 percent kill): 44,000 mg/m³ N/R VCVGH* -,91,1990
oral
mouse lethal dose (50 percent kill): 800 mg/kg N/R TPKVAL 9,27,1967
oral
rat lethal dose (50 percent kill): 113 mg/kg N/R NTIS OTS0535718
skin
rabbit lethal dose (50 percent kill): 430 mg/kg N/R NTIS OTS0535718

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 350 mg/m³/4 hour/26 week- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count GTPZAB 9(12),13,1965

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 75 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 75 ppm (200 mg/m³) DTLVS* 3,66,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 75 ppm (200 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 75 ppm (200 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 75 ppm (200 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 75 ppm (200 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 75 ppm (200 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 75 ppm (200 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 75 ppm (203 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 75 ppm (200 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 75 ppm (200 mg/m³), short term exposure limit 115 ppm (310 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 75 ppm (200 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 75 ppm (200 mg/m³), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 20 mg/m³, short term exposure limit 40 mg/m³, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 200 mg/m³, 2003
Occupational Exposure Limit - NORWAY time-weighted average 40 ppm (110 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 75 ppm (200 mg/m³), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 200 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m³, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 75 ppm (200 mg/m³), JAN1999
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 75 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 75 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOPENTADIENE-air 10 hour time-weighted average 75 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 20065;
Number of Industries 19;
Total Number of Facilities 3,138;
Number of Occupations 26;
Total Number of Employees Exposed 18,381
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 20065;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 3;
Total Number of Employees Exposed 51

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of resins and in organic synthesis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,3-Cyclopentadiene, 2523

REFERENCES:
CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in manufacture of resins and in organic synthesis

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (CYCLOPENTADIENES), SRC, 12/79

NIOSH PROFILE (ALKENES), SRC, 4/78

RTECS Compound Description:
Human Data

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