The Registry of Toxic Effects of Chemical Substances

Cyclopropanecarboxylic acid, 3 - (2,2 - dibromoethenyl) - 2,2 - dimethyl - , cyano (3 - phenoxyphenyl) methyl ester, (1R - (1 - alpha (S*) ,3 - alpha) ) -

RTECS #: GZ1233000

CAS #: 52918-63-5

UPDATE: February 2005 MW: 505.24 MF: C22H19Br2NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Butox
  2. Cislin
  3. Crackdown
  4. Decamethrin
  5. Decamethrine
  6. Decis
  7. Dekametrin (Hungarian)
  8. Deltagran
  9. Deltamethrin
  1. Deltamethrine
  2. Deltametryna (Polish)
  3. FMC 45498
  4. K - Othrin
  5. K - Othrine
  6. NRDC 161
  7. OMS 1988
  8. RU 22974
  9. RUP 987


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL/24 hour N/R NTIS** OTS0545196


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis multiple
other fish 		100 nL/L JFIBA9 26,13,1985
cytogenetic analysis intraperitoneal
rat 		11,200 µg/kg MUREAV 311,133,1994
cytogenetic analysis subcutaneous
rat 		11,200 µg/kg MUREAV 311,133,1994
cytogenetic analysis oral
rat 		11,200 µg/kg MUREAV 311,133,1994
dominant lethal test oral
mouse 		10,080 µg/kg/2 week- continuous MUREAV 467,119,2000
DNA inhibition human lymphocyte 110 µmol/L DCTODJ 10,291,1987
DNA inhibition mouse leukocyte 500 µmol/L DCTODJ 10,291,1987
micronucleus test human lymphocyte 100 mg/L MUREAV 341,169,1995
micronucleus test intraperitoneal
mouse 		325 mg/kg/24 hour- continuous MUREAV 346,203,1995
micronucleus test intraperitoneal
rat 		5,600 µg/kg MUREAV 311,133,1994
other mutation test systems intraperitoneal
rat 		5,600 µg/kg MUREAV 311,133,1994
other mutation test systems subcutaneous
rat 		5,600 µg/kg MUREAV 311,133,1994
other mutation test systems oral
rat 		5,600 µg/kg MUREAV 311,133,1994
sister chromatid exchange human lymphocyte 60 mg/L MUREAV 283,113,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 21 mg/kg (21 day male) Reproductive: Other effects on male TXCYAC 132,1,1999
oral
mouse 		lowest published toxic dose: 30 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JEPTDQ 2(3),751,1979
oral
mouse 		lowest published toxic dose: 50 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		TCMUD8 7,7,1987
oral
rat 		lowest published toxic dose: 70 mg/kg (7-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JEPTDQ 2(3),751,1979
oral
rat 		lowest published toxic dose: 10 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) DTTIAF 100,142,1992
oral
rat 		lowest published toxic dose: 0.8 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		NETEEC 23,665,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 384 mg/kg/32 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		TXCYAC 163,1,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 26,100 µg/kg N/R PCBPBS 24,200,1985
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 2.2 gm/m3 N/R FEREAC 63,45408,1998
inhalation
rat 		lethal concentration (50 percent kill): 785 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		JEPTDQ 2(3),751,1979
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R EVHPAZ 21,285,1977
intravenous
dog 		lethal dose (50 percent kill): 3,440 µg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		IJTEDP 6,127,1984
intravenous
rat 		lethal dose (50 percent kill): 2,526 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		PCBPBS 30,79,1988
intravenous
rat 		lowest published toxic dose: 0.5 mg/kg Endocrine: Adrenal cortex hyperplasia TXCYAC 49,263,1988
intravenous
rat 		lowest published toxic dose: 0.15 mg/kg Behavioral: Alteration of classical conditioning

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS 		TXCYAC 49,263,1988
intravenous
rabbit 		lethal dose (50 percent kill): 1,350 mg/kg N/R NAYXEW 10,115,1990
oral
duck 		lethal dose (50 percent kill): >4,640 mg/kg N/R PEMNDP 9,232,1991
oral
dog 		lethal dose (50 percent kill): >300 gm/kg N/R PEMNDP 9,232,1991
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 5,000 mg/kg N/R FEREAC 63,45408,1998
oral
mouse 		lethal dose (50 percent kill): 20 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		JEBIDP 12,45,1991
oral
rat 		lethal dose (50 percent kill): 9,360 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		JEBIDP 12,45,1991
oral
rat 		lethal dose (50 percent kill): 5.1 mg/kg N/R HBPTO* 1,881,2001
oral
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Tremor FCTOD7 41,431,2003
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 2,000 mg/kg N/R FEREAC 63,45408,1998
skin
mouse 		lowest published toxic dose: 4 mg/kg Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens 		TXCYAC 163,1,2001
skin
rat 		lethal dose (50 percent kill): >800 mg/kg N/R JEPTDQ 2(3),751,1979
skin
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R DEVEAA 33,76,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 35 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		JEPOEC 14,45,1995
intraperitoneal
rat 		lowest published toxic dose: 3.5 mg/kg/5 day- intermittent Vascular: Other changes

Reproductive: Specific developmental abnormalities: Central nervous system 		HBPTO* 2,1298,2001
intraperitoneal
rat 		lowest published toxic dose: 240 mg/kg/6 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS TOXID9 72,306,2003
oral
mammal (species unspecified) 		lowest published toxic dose: 504 mg/kg/84 day- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		HBPTO* 1,777,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 210 mg/kg/14 day- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		HBPTO* 1,777,2001
oral
mouse 		lowest published toxic dose: 39 mg/kg/13 week- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Endocrine: Changes in spleen weight 		JEBIDP 12,45,1991
oral
mouse 		lowest published toxic dose: 210 mg/kg/2 week- intermittent Blood: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		ENVRAL 59,467,1992
oral
quail 		lowest published toxic dose: 1,228 mg/kg/7 day- continuous Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		BECTA6 31,479,1983
oral
rat 		lowest published toxic dose: 105 mg/kg/15 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHD6 48,515,1996
oral
rat 		lowest published toxic dose: 450 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria 		BCTKAG 21,146,1988
oral
rat 		lowest published toxic dose: 140 mg/kg/7 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		ARTODN 53,297,1983
oral
rat 		lowest published toxic dose: 12,500 µg/kg/10 day- intermittent Behavioral: Food intake (animal)

Liver: Other changes 		WDZAEK 8,189,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,251,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,251,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,251,1991
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
TOLED5 127,29,2002
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
TOLED5 1422072003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,363,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
Used as an insecticide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJTEDP International Journal on Tissue Reactions. Experimental and Clinical Aspects. (Biosciences Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1979-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JEBIDP Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1- 1980-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JFIBA9 Journal of Fish Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAYXEW Nanjing Yixueyuan Xuebao. Journal of Nanjing Medical College. (Nanjing Yixueyuan, 140 Hanzhonglu, Nanjing, Peop. Rep. China) V.1- 1981(?)-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 55700-96-4
ALT CAS #: 62229-77-0
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