The Registry of Toxic Effects of Chemical Substances

Cyclotetrasiloxane, octamethyl -

RTECS #: GZ4397000

CAS #: 556-67-2

UPDATE: August 2004 MW: 296.68 MF: C8H24O4Si4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cyclic dimethylsiloxane tetramer
  2. D4
  3. KF 994
  4. NUC silicone VS 7207
  5. Octamethylcyclotetrasiloxane
  6. Oktamethylcyklotetrasiloxan (Czech)
  1. SF 1173
  2. Silicone SF 1173
  3. Union carbide 7207
  4. UC 7207
  5. VS 7207


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,1230,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,1230,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 ppm (70 day male/70 day prior to copulation-3 week after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TOXID9 54,370,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 36 gm/m3/4 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		NTIS** OTS0557551
oral
rat 		lethal dose (50 percent kill): 1,540 mg/kg Behavioral: Tremor NTIS** OTS0538262
skin
rat 		lethal dose (50 percent kill): 1,770 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Liver: Other changes 		NTIS** OTS0538262
skin
rabbit 		lethal dose (50 percent kill): 794 µL/kg Kidney, Ureter, and Bladder: Hematuria NTIS** OTS0538262


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 697 ppm/6 hour/28 day- intermittent Liver: Changes in liver weight NTIS** OTS0516677
inhalation
mouse 		lowest published toxic concentration: 697 ppm/6 hour/28 day- intermittent Liver: Changes in liver weight NTIS** OTS0516677
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight NTIS** OTS0530406
inhalation
rat 		lowest published toxic concentration: 700 ppm/6 hour/4 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		NTIS** OTS0573657
inhalation
rat 		lowest published toxic dose: 70 ppm/6 hour/4 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight 		TXAPA9 172,83,2001
inhalation
rat 		lowest published toxic concentration: 35 ppm/6 hour/91 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		IJOTO* 21,39,2002
inhalation
rat 		lowest published toxic concentration: 488 ppm/6 hour/91 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Changes in testicular weight 		IJOTO* 21,39,2002
inhalation
rat 		lowest published toxic concentration: 488 ppm/6 hour/91 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight 		IJOTO* 21,39,2002
inhalation
rat 		lowest published toxic concentration: 898 ppm/6 hour/91 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		IJOTO* 21,39,2002
inhalation
rat 		lowest published toxic concentration: 898 ppm/6 hour/91 day- intermittent Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in ovarian weight 		IJOTO* 21,39,2002
oral
mouse 		lowest published toxic dose: 750 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		TXAPA9 192,254,2003
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOXID9 72,111,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3232;
Number of Industries 8;
Total Number of Facilities 128;
Number of Occupations 12;
Total Number of Employees Exposed 3,383;
Total Number of Female Employees Exposed 1,689


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IJOTO* International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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