The Registry of Toxic Effects of Chemical Substances

Decaborane (14)

RTECS #: HD1400000

CAS #: 17702-41-9


UPDATE: November 2004 MW: 122.24 MF: B10H14


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Boron hydride (B10H14)
  2. Decaborane
  3. Decaborane (ACGIH:OSHA)
  1. Decaborane (14) fumes
  2. Tetradecahydrodecaborane
  3. nido - Decaborane (14)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
lowest published toxic dose: 0.1 mg/kg/5 minute Eye: Conjunctiva irritation

Eye: Corneal damage
VCVN1* -,201,1988
inhalation
mouse
lethal concentration (50 percent kill): 12 ppm/4 hour Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** AD224-006
inhalation
mouse
lethal concentration (50 percent kill): 30 mg/m3 N/R VCVN1* -,199,1988
inhalation
rat
lethal concentration (50 percent kill): 46 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
AMIHAB 17,362,1958
inhalation
rat
lethal concentration (50 percent kill): 110 mg/m3/4 hour N/R VCVN1* -,199,1988
intraperitoneal
mouse
lethal dose (50 percent kill): 33 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
AMIHAB 11,132,1955
intraperitoneal
mouse
lethal dose (50 percent kill): 33 mg/kg Behavioral: Coma VCVN1* -,199,1988
intraperitoneal
rat
lethal dose (50 percent kill): 23 mg/kg N/R AMIHBC 8,335,1953
intraperitoneal
rat
lethal dose (50 percent kill): 23 mg/kg Behavioral: Coma VCVN1* -,199,1988
intraperitoneal
rabbit
lethal dose (50 percent kill): 28 mg/kg N/R AMIHBC 8,335,1953
intraperitoneal
rabbit
lethal dose (50 percent kill): 28 mg/kg Behavioral: Coma VCVN1* -,199,1988
oral
mouse
lethal dose (50 percent kill): 41 mg/kg Eye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
AMIHAB 11,132,1955
oral
rat
lethal dose (50 percent kill): 64 mg/kg N/R MLSR** #8,1951
oral
rat
lethal dose (50 percent kill): 64 mg/kg Behavioral: Coma VCVN1* -,199,1988
skin
cat
lethal dose (50 percent kill): 126 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
STGNBT -,60,1999
skin
cat
lethal dose (50 percent kill): 126 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
guinea pig
lethal dose (50 percent kill): 158 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
STGNBT -,60,1999
skin
guinea pig
lethal dose (50 percent kill): 158 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
mouse
lethal dose (50 percent kill): 317 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
STGNBT -,60,1999
skin
mouse
lethal dose (50 percent kill): 317 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
rat
lethal dose (50 percent kill): 740 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 11,132,1955
skin
rat
lethal dose (50 percent kill): 740 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
rabbit
lethal dose (50 percent kill): 71 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 11,132,1955
skin
rabbit
lethal dose (50 percent kill): 57 mg/kg/4 hour N/R VCVN1* -,201,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 22 mg/m3/5 hour/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
rat
lowest published toxic concentration: 22 mg/m3/5 hour/135 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
oral
rat
lowest published toxic dose: 9,100 g/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Blood: Pigmented or nucleated red blood cells
STGNBT -,60,1999
oral
rabbit
lowest published toxic dose: 1,050 g/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Vascular: Other changes

Lung, Thorax, or Respiration: Other changes
STGNBT -,60,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin);short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 ppm (0.3 mg/m3) (skin) DTLVS* 3,68,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 005 ppm (0.3 mg/m3), short term exposure limit 0.15 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.25 mg/m3), short term exposure limit 0.15 ppm, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.05 ppm (0.25 mg/m3), short term exposure limit 0.15 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.3 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 ppm (0.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.25 mg/m3), KZG- week 0.1 ppm, Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.05 ppm (0.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.15 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.15 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DECABORANE-air 10 hour time-weighted average 0.05 ppm (Sk);
short term exposure limit 0.15 ppm (Sk)
NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a catalyzer in polymers production
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MLSR** U.S. Army, Chemical Corps Medical Laboratories Special Reports. (Army Chemical Center, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a catalyzer in polymers production

ALT CAS #: 1304-02-5
Click Here for Additional Information about RTECS