RTECS:HP3500000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

Dibenzo - p - dioxin, 2,3,7,8 - tetrachloro -

RTECS #: HP3500000

CAS #: 1746-01-6

UPDATE: May 2005 MW: 321.96 MF: C₁₂H₄Cl₄O₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,3,7,8 - Czterochlorodwubenzo - p - dwuoksyny (Polish)

2,3,7,8 - TCDD

2,3,7,8 - Tetrachlorodibenzo (b,e) (1,4) dioxan

2,3,7,8 - Tetrachlorodibenzo - 1,4 - dioxin

2,3,7,8 - Tetrachlorodibenzo - p - dioxin

2,3,7,8 - Tetrachlorodibenzo - p - dioxin (TCDD)

Dibenzo (b,e) (1,4) dioxin, 2,3,7,8 - tetrachloro -

Dioksyny (Polish)

Dioxin

Dioxin (herbicide contaminant)

Dioxine

NCI - C03714

TCDBD

TCDD

Tetradioxin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 2 mg moderate EVHPAZ 5,87,1973

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis oral
mouse 100 痢/kg TXAPA9 29,229,1974
cytogenetic analysis intraperitoneal
mouse 10 痢/kg PSSID2 5,419,1982
cytogenetic analysis oral
rat 100 痢/kg MUREAV 47,141,1978
cytogenetic analysis intraperitoneal
rat 10 mg/kg MUREAV 47,141,1978
DNA adduct intraperitoneal
rat 40 痢/kg/4 week- intermittent CMSHAF 25,975,1992
DNA adduct oral
rat 0.21 mg/kg/30 week- intermittent CRTOEC 14,849,2001
DNA damage mouse other cell types 10 nmol/L/24 hour TOLED5 145,55,2003
DNA damage oral
rat 100 痢/kg CALEDQ 39,281,1988
DNA damage unreported route
rat 100 痢/kg CALEDQ 29,281,1988
DNA damage oral
rat 450 ng/kg/30 week- intermittent JJTHEC 65,825,2002
DNA inhibition human other cell types 10 nmol/L TXAPA9 77,434,1985
DNA inhibition intraperitoneal
mouse 400 痢/kg MUREAV 46,305,1977
DNA inhibition intraperitoneal
rat 10 痢/kg CBINA8 8,31,1974
DNA inhibition oral
rat 200 痢/kg CBINA8 8,31,1974
unscheduled DNA synthesis human other cell types 100 pmol/L CRNGDP 11,1335,1990
unscheduled DNA synthesis oral
mouse 800 pmol/kg CRNGDP 8,1433,1987
unscheduled DNA synthesis intravenous
rat 4 痢/kg BCPCA6 31,2459,1982
unscheduled DNA synthesis oral
rat 5 痢/kg TXCYAC 28,133,1983
host-mediated assay mouse
Saccharomyes cerevisiae 25 痢/kg CMSHAF 12,549,1983
mutation in microorganisms Escherichia coli 2 mg/L (-enzymatic activation step) AMBOCX 1,1,1972
mutation in microorganisms Salmonella typhimurium 2 mg/L (+enzymatic activation step) AMBOCX 1,32,1972
mutation in microorganisms Saccharomyes cerevisiae 10 mg/L (-enzymatic activation step) CMSHAF 12,549,1983
mutation in microorganisms Saccharomyes cerevisiae 2 mg/L (+enzymatic activation step) PSSID2 5,429,1982
gene conversion and mitotic recombination hamster ovary 0.5 nmol/L/24 hour TOXID9 72,369,2003
gene conversion and mitotic recombination Saccharomyes cerevisiae 10 mg/L CMSHAF 12,549,1983
mutation in mammalian somatic cells mouse lymphocyte 50 mg/L ENMUDM 4,391,1982
morphological transform mouse fibroblast 200 nmol/L ENMUDM 6,461,1984
morphological transform mouse fibroblast 10 nmol/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems mouse other cell types 1 nmol/L JBCHA3 259,12357,1984
other mutation test systems oral
mouse 50 痢/kg TXCYAC 56,239,1989
phage inhibition capacity Escherichia coli 500 痢/L AMBOCX 1,1,1972

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 25 痢/kg (7-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXCYAC 20,299,1981
intraperitoneal
mouse lowest published toxic dose: 20 痢/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ATSUDG 8,43,1985
intraperitoneal
mouse lowest published toxic dose: 30 痢/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TOXID9 72(Suppl 1),231,2003
intraperitoneal
rat lowest published toxic dose: 6 痢/kg (17 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BCPCA6 26,1383,1977
intraperitoneal
rat lowest published toxic dose: 50 痢/kg (1 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TXAPA9 173,38,2001
oral
hamster lowest published toxic dose: 18 痢/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death CMSHAF 20,1117,1990
oral
hamster lowest published toxic dose: 2 痢/kg (11 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects TOSCF2 51,259,1999
oral
hamster lowest published toxic dose: 1 痢/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 131,108,1995
oral
hamster lowest published toxic dose: 2 痢/kg (11 day pregnant) Reproductive: Effects on newborn: Physical TOSCF2 51,259,1999
oral
mammal (species unspecified) lowest published toxic dose: 19 痢/kg (132 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) VHTODE 43,134,2001
oral
mammal (species unspecified) lowest published toxic dose: 2.4 痢/kg (132 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) VHTODE 43,134,2001
oral
mammal (species unspecified) lowest published toxic dose: 699.6 ng/kg (132 day prior to copulation) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) VHTODE 43,134,2001
oral
monkey lowest published toxic dose: 92 ng/kg (46 week prior to copulation-17 week after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects NETEEC 11,13,1989
oral
monkey lowest published toxic dose: 107 mg/kg (4 year male) Reproductive: Effects on newborn: Behavioral CMSHAF 20,1103,1990
oral
monkey lowest published toxic dose: 123 ng/kg (30 week prior to copulation-17 week after birth) Reproductive: Effects on newborn: Behavioral TOXID9 3,68,1983
oral
monkey lowest published toxic dose: 163 ng/kg (182 week prior to copulation) Reproductive: Effects on newborn: Behavioral NETEEC 14,433,1992
oral
monkey lowest published toxic dose: 2 痢/kg (12 day pregnant) Reproductive: Effects on fertility: Abortion BESCE5 13,26,2000
oral
monkey lowest published toxic dose: 0.535 痢/kg (30 week prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion ANYAA9 -,419,1979
oral
mouse lowest published toxic dose: 1 痢/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system EVHPAZ 5,81,1973
oral
mouse lowest published toxic dose: 9 痢/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 98,487,1989
oral
mouse lowest published toxic dose: 13,500 mg/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TJADAB 44,385,1991
oral
mouse lowest published toxic dose: 235 痢/kg (28 day prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system DCTODJ 2,77,1979
oral
mouse lowest published toxic dose: 20 痢/kg (14 day pregnant/3 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects IJIMDS 2,301,1980
oral
mouse lowest published toxic dose: 12 痢/kg (10-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death TJADAB 33,29,1986
oral
mouse lowest published toxic dose: 10 痢/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system MOPMA3 35,18,1989
oral
mouse lowest published toxic dose: 12 痢/kg (10-13 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TOXID9 13,103,1993
oral
mouse lowest published toxic dose: 240 痢/kg (1 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) ARTODN 69,87,1994
oral
mouse lowest published toxic dose: 320 痢/kg (1 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ARTODN 69,87,1994
oral
mouse lowest published toxic dose: 480 痢/kg (1 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system ARTODN 69,87,1994
oral
mouse lowest published toxic dose: 3 痢/kg (8 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical TOSCF2 52,45,1999
oral
mouse lowest published toxic dose: 15 痢/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) CMSHAF 25,103,1992
oral
mouse lowest published toxic dose: 50 痢/kg (105 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other reproductive system tumors EVHPAZ 105,750,1997
oral
mouse lowest published toxic dose: 5 痢/kg (9 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ARTODN 67,591,1993
oral
mouse lowest published toxic dose: 40 痢/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TCMUD8 20,73,2000
oral
mouse lowest published toxic dose: 5 痢/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 72(Suppl 1),365,2003
oral
mouse lowest published toxic dose: 10 痢/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),366,2003
oral
mouse lowest published toxic dose: 10 痢/kg (17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),366,2003
oral
mouse lowest published toxic dose: 6 痢/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),231,2003
oral
mouse lowest published toxic dose: 0.2 痢/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system TOSCF2 71,84,2003
oral
mouse lowest published toxic dose: 5 痢/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Skin and skin appendages TOSCF2 68,465,2002
oral
mouse lowest published toxic dose: 5 痢/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects TOSCF2 68,479,2002
oral
mouse lowest published toxic dose: 5 痢/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Urogenital system TOSCF2 76,171,2003
oral
mouse lowest published toxic dose: 5 痢/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system TOSCF2 71,84,2003
oral
rat lowest published toxic dose: 1,500 ng/kg (1-3 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system TJADAB 25(1),21A,1982
oral
rat lowest published toxic dose: 1,250 ng/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities FCTXAV 9,405,1971
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other neonatal measures or effects TXAPA9 150,254,1998
oral
rat lowest published toxic dose: 1,270 ng/kg (multigenerations) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 50,241,1979
oral
rat lowest published toxic dose: 1 痢/kg (15 day after birth) Reproductive: Effects on newborn: Physical TXAPA9 140,146,1996
oral
rat lowest published toxic dose: 20 痢/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina TXCYAC 21,77,1981
oral
rat lowest published toxic dose: 12 痢/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Urogenital system TJADAB 55,326,1997
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 13,104,1993
oral
rat lowest published toxic dose: 1 痢/kg (8 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 133,285,1995
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 133,285,1995
oral
rat lowest published toxic dose: 0.5 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 146,11,1997
oral
rat lowest published toxic dose: 56 mg/kg (10-16 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOLED5 78,253,1995
oral
rat lowest published toxic dose: 0.7 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral TOXID9 14,197,1994
oral
rat lowest published toxic dose: 0.64 痢/kg (15 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 10,313,1990
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 127,241,1994
oral
rat lowest published toxic dose: 0.7 痢/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 127,250,1994
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system BIREBV 55,62,1996
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 140,146,1996
oral
rat lowest published toxic dose: 1 痢/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 15,292,1995
oral
rat lowest published toxic dose: 1 痢/kg (18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 15,292,1995
oral
rat lowest published toxic dose: 1 痢/kg (8 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical TOSCF2 52,45,1999
oral
rat lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus

Reproductive: Effects on newborn: Biochemical and metabolic ETOPFR 11,1,2002
oral
rat lowest published toxic dose: 0.3 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 174,216,2001
oral
rat lowest published toxic dose: 1.4 痢/kg (10-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects NETEEC 22,511,2001
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) TXAPA9 134,241,1995
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects TXAPA9 134,241,1995
oral
rat lowest published toxic dose: 0.35 痢/kg (16 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system CMSHAF 18,955,1989
oral
rat lowest published toxic dose: 0.125 痢/kg (16 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system CMSHAF 18,955,1989
oral
rat lowest published toxic dose: 13 痢/kg (7-19 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Other developmental abnormalities BCPCA6 32,991,1983
oral
rat lowest published toxic dose: 12 痢/kg (4-15 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system BCPCA6 32,991,1983
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical BIRSB5 62,184,2000
oral
rat lowest published toxic dose: 0.18 痢/kg (15 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects NETEEC 24,209,2002
oral
rat lowest published toxic dose: 45 ng/kg (45 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands JJATDK 22,345,2002
oral
rat lowest published toxic dose: 700 ng/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Other developmental abnormalities TOXID9 72,125,2003
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Biochemical and metabolic EVHPAZ 110(Suppl 3),369,2002
oral
rat lowest published toxic dose: 20 ng/kg (8 day pregnant) Endocrine: Differential effect of sex or castration on observed toxicity

Reproductive: Effects on newborn: Behavioral EVHPAZ 110,247,2002
oral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Specific developmental abnormalities: Endocrine system BIREBV 66,1621,2002
oral
rat lowest published toxic dose: 20 ng/kg (18 day pregnant) Reproductive: Effects on newborn: Behavioral EVHPAZ 109,621,2001
oral
rat lowest published toxic dose: 1 痢/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Stillbirth TXAPA9 184,57,2002
oral
rat lowest published toxic dose: 800 ng/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral NRTXDN 24,207,2003
oral
rat lowest published toxic dose: 1,000 ng/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 72(Suppl 1),232,2003
oral
rat lowest published toxic dose: 0.7 痢/kg (10-16 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects NETEEC 25,459,2003
oral
rabbit lowest published toxic dose: 2,500 ng/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Urogenital system ENVRAL 27,74,1982
oral
rabbit lowest published toxic dose: 10 痢/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Abortion ENVRAL 27,74,1982
oral
rabbit lowest published toxic dose: 1 痢/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ENVRAL 27,74,1982
parenteral
rat lowest published toxic dose: 1 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 14,197,1994
subcutaneous
mouse lowest published toxic dose: 250 痢/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system BECTA6 16,674,1976
subcutaneous
mouse lowest published toxic dose: 250 痢/kg (7-16 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death BECTA6 16,674,1976
subcutaneous
mouse lowest published toxic dose: 100 痢/kg (2 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TCMUD8 4,427,1984
subcutaneous
mouse lowest published toxic dose: 30 痢/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) MOPMA3 17,86,1980
subcutaneous
mouse lowest published toxic dose: 100 痢/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TCMUD8 4,427,1984
subcutaneous
mouse lowest published toxic dose: 90 痢/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 21,62A,1980
subcutaneous
mouse lowest published toxic dose: 90 痢/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 21,62A,1980
subcutaneous
mouse lowest published toxic dose: 90 痢/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 21,62A,1980
subcutaneous
rat lowest published toxic dose: 5 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 20,396,1971
subcutaneous
rat lowest published toxic dose: 2,200 ng/kg (19 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) CMSHAF 25,1227,1992
subcutaneous
rat lowest published toxic dose: 0.5 痢/kg (7-20 day pregnant/9-16 day after birth) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Biochemical and metabolic BCPCA6 62,617,2001
subcutaneous
rat lowest published toxic dose: 185 ng/kg (2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Germ cell effects (in offspring) TXAPA9 150,383,1998
subcutaneous
rat lowest published toxic dose: 2,700 ng/kg (2 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 150,383,1998
subcutaneous
rat lowest published toxic dose: 3 痢/kg (19 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TJADAB 40,292,1989
subcutaneous
rat lowest published toxic dose: 0.5 痢/kg (7-20 day pregnant/2 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system BCPCA6 59,1147,2000
unreported route
mouse lowest published toxic dose: 12 痢/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system CMSHAF 25,115,1992
unreported route
mouse lowest published toxic dose: 5 痢/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72,113,2003
unreported route
mouse lowest published toxic dose: 1.5 痢/kg (0-14 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOXID9 72,121,2003
unreported route
mouse lowest published toxic dose: 5.5 痢/kg (0-14 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) TOXID9 72,121,2003
unreported route
rat lowest published toxic dose: 1,500 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands ATSUDG 11,344,1987
unreported route
rat lowest published toxic dose: 0.7 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 14,382,1994
unreported route
rat lowest published toxic dose: 0.8 痢/kg (15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) HBPTO* 1,741,2001
unreported route
rat lowest published toxic dose: 0.2 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system HBPTO* 1,741,2001
unreported route
rat lowest published toxic dose: 0.5 痢/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Physical HBPTO* 1,741,2001

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 1.61 痢/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Facilitates action of known carcinogens TXAPA9 179,21,2002
oral
mouse lowest published toxic dose: 52 痢/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors NTPTR* NTP-TR-209,1982
oral
mouse toxic dose : 1 痢/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors NTPTR* NTP-TR-209,1982
oral
mouse toxic dose : 36 痢/kg/52 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors NATUAS 278,548,1979
oral
mouse lowest published toxic dose: 0.52 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors NTIS PB82-163445
oral
mouse lowest published toxic dose: 0.208 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors NTIS PB82-163445
oral
rat lowest published toxic dose: 52 痢/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors NTPTR* NTP-TR-209,1982
oral
rat toxic dose : 328 痢/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors PESTC* 5,12,1977
oral
rat toxic dose : 137 痢/kg/65 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors FEPRA7 36,396,1977
oral
rat toxic dose : 73 痢/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors ANYAA9 320,397,1979
oral
rat toxic dose : 1 痢/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors NTPTR* NTP-TR-209,1982
oral
rat lowest published toxic dose: 164 痢/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors CMSHAF 6,625,1977
oral
rat toxic dose : 190 痢/kg/95 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors CMSHAF 6,537,1977
oral
rat toxic dose : 27 痢/kg/65 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors FEPRA7 36,396,1977
oral
rat lowest published toxic dose: 0.52 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors NTIS PB82-163445
oral
rat lowest published toxic dose: 0.52 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors NTIS PB82-163445
skin
mouse lowest published toxic dose: 62 痢/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors NCITR* NCI-TR-201,1982
skin
mouse toxic dose : 80 痢/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application BECTA6 18,552,1977
skin
mouse lowest published toxic dose: 0.594 mg/kg/99 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors NTIS PB82-163684
skin
mouse lowest published toxic dose: 0.1,188 mg/kg/99 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors NTIS PB82-163684

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
wild bird lowest published toxic dose: 20 痢/kg Endocrine: Evidence of thyroid hyperfunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) ETOCDK 16,985,1997
intraperitoneal
chicken lowest published lethal dose: 25 痢/kg Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Other changes JTEHD6 35,187,1992
intraperitoneal
guinea pig lowest published toxic dose: 29.9 ng/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects BCPCA6 36,1535,1988
intraperitoneal
guinea pig lowest published toxic dose: 1.8 痢/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain BCPCA6 36,1535,1988
intraperitoneal
hamster lethal dose (50 percent kill): >3 mg/kg Endocrine: Changes in thymus weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 55,67,1980
intraperitoneal
hamster lowest published toxic dose: 1 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BCPCA6 35,2737,1986
intraperitoneal
hamster lowest published toxic dose: 10 痢/kg Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain BCPCA6 35,2737,1986
intraperitoneal
hamster lowest published toxic dose: 100 痢/kg Endocrine: Changes in thymus weight BCPCA6 35,2737,1986
intraperitoneal
hamster lowest published toxic dose: 500 痢/kg Liver: Other changes BCPCA6 35,2737,1986
intraperitoneal
mouse lethal dose (50 percent kill): 120 痢/kg N/R SCAMAC 254,29,1986
intraperitoneal
mouse lowest published toxic dose: 0.6 痢/kg Immunological Including Allergic: Decrease in humoral immune response TXCYAC 92,155,1994
intraperitoneal
mouse lowest published toxic dose: 10 痢/kg Blood: Luekopenia

Blood: Changes in bone marrow not included in above CMSHAF 43,819,2001
intraperitoneal
mouse lowest published toxic dose: 9.66 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977
intraperitoneal
mouse lowest published toxic dose: 782 ng/kg Immunological Including Allergic: Decrease in humoral immune response

Immunological Including Allergic: Decreased immune response TXAPA9 94,141,1988
intraperitoneal
mouse lowest published toxic dose: 1.5 痢/kg Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decreased immune response TXCYAC 80,217,1993
intraperitoneal
mouse lowest published toxic dose: 0.29 痢/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases TXCYAC 80,217,1993
intraperitoneal
mouse lowest published toxic dose: 20 痢/kg Blood: Changes in bone marrow not included in above

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides AECTCV 41,232,2001
intraperitoneal
mouse lowest published toxic dose: 50 痢/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 72,66,2003
intraperitoneal
mouse lowest published toxic dose: 0.1 痢/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 72,66,2003
intraperitoneal
mouse lowest published toxic dose: 30 痢/kg Endocrine: Other changes

Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases CMSHAF 25,103,1992
intraperitoneal
mouse lowest published toxic dose: 11.19 痢/kg Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 63,97,1990
intraperitoneal
mouse lowest published toxic dose: 0.5 mg/kg Endocrine: Changes in thymus weight BBRCA9 178,16,1991
intraperitoneal
mouse lowest published toxic dose: 30 痢/kg Endocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above TOSCF2 69,117,2002
intraperitoneal
mouse lowest published toxic dose: 15 痢/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TXAPA9 181,32,2002
intraperitoneal
mouse lowest published toxic dose: 115 痢/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 172,125,2002
intraperitoneal
mouse lowest published toxic dose: 0.1 痢/kg Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects TXCYAC 178,241,2002
intraperitoneal
mouse lowest published toxic dose: 5 痢/kg Liver: Fatty liver degeneration TOXID9 72(Suppl 1),336,2003
intraperitoneal
mouse lowest published toxic dose: 10 痢/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 72(Suppl 1),231,2003
intraperitoneal
mouse lowest published toxic dose: 5 痢/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOSCF2 66,62,2002
intraperitoneal
mouse lowest published toxic dose: 0.1 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOSCF2 69,109,2002
intraperitoneal
mouse lowest published toxic dose: 1 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport TOSCF2 69,109,2002
intraperitoneal
mouse lowest published toxic dose: 10 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOSCF2 69,109,2002
intraperitoneal
mouse lowest published toxic dose: 30 痢/kg Endocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above

Immunological Including Allergic: Decreased immune response TOLED5 129,1,2002
intraperitoneal
rat lethal dose (50 percent kill): 24,600 ng/kg N/R TXAPA9 45,513,1978
intraperitoneal
rat lowest published toxic dose: 1 痢/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 150,427,1998
intraperitoneal
rat lowest published toxic dose: 10 痢/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects TXAPA9 150,427,1998
intraperitoneal
rat lowest published toxic dose: 12.5 痢/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 89,49,1994
intraperitoneal
rat lowest published toxic dose: 82.4 痢/kg Endocrine: Estrogenic

Endocrine: Other changes CMSHAF 19,785,1989
intraperitoneal
rat lowest published toxic dose: 100 痢/kg Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 16,481,1985
intraperitoneal
rat lowest published toxic dose: 9.66 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977
intraperitoneal
rat lowest published toxic dose: 1 痢/kg Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 44,297,1987
intraperitoneal
rat lowest published lethal dose: 25 痢/kg Endocrine: Other changes TXCYAC 44,297,1987
intraperitoneal
rat lowest published toxic dose: 125 痢/kg Behavioral: Food intake (animal)

Endocrine: Hypoglycemia TXCYAC 44,297,1987
intraperitoneal
rat lowest published toxic dose: 10.3 痢/kg Liver: Other changes

Endocrine: Estrogenic TXAPA9 95,435,1988
intraperitoneal
rat lowest published toxic dose: 20 痢/kg Endocrine: Estrogenic TXAPA9 92,368,1988
intraperitoneal
rat lowest published toxic dose: 10 痢/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 29,61,1983
intraperitoneal
rat lowest published toxic dose: 5 痢/kg Endocrine: Changes in spleen weight

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases ATXKA8 53,177,1983
intraperitoneal
rat lowest published toxic dose: 5 痢/kg Liver: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases ARTODN 53,177,1983
intraperitoneal
rat lowest published toxic dose: 5 痢/kg Endocrine: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases ARTODN 53,177,1983
intraperitoneal
rat lowest published toxic dose: 125 痢/kg Behavioral: Food intake (animal)

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport ARTODN 62,146,1988
intraperitoneal
rat lowest published toxic dose: 10 痢/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport LPDSAP 23,904,1988
intraperitoneal
rat lowest published toxic dose: 1 痢/kg Liver: Changes in liver weight

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport LPDSAP 23,904,1988
intraperitoneal
rat lowest published toxic dose: 10 痢/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport JPETAB 248,62,1989
intraperitoneal
rat lowest published toxic dose: 5 痢/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases ARTODN 53,177,1983
intraperitoneal
rat lethal dose (50 percent kill): 60 痢/kg Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases BBRCA9 125,996,1984
intraperitoneal
rat lowest published toxic dose: 2.5 痢/kg Endocrine: Changes in thymus weight BBRCA9 160,1003,1989
intraperitoneal
rat lowest published toxic dose: 25 痢/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain BBRCA9 160,1003,1989
intraperitoneal
rat lowest published toxic dose: 50 痢/kg Endocrine: Change in gonadotropins

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites TXAPA9 94,496,1988
intraperitoneal
rat lowest published toxic dose: 12.5 痢/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 76,103,1992
intraperitoneal
rat lowest published toxic dose: 25 痢/kg Endocrine: Androgenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 76,103,1992
intraperitoneal
rat lowest published toxic dose: 50 痢/kg Related to Chronic Data: Changes in testicular weight TXCYAC 76,103,1992
intraperitoneal
rat lowest published toxic dose: 25 痢/kg Behavioral: Food intake (animal)

Endocrine: Adrenal cortex hyperplasia

Endocrine: Changes in thymus weight TXCYAC 53,19,1988
intraperitoneal
rat lowest published lethal dose: 125 痢/kg N/R TXCYAC 53,19,1988
intraperitoneal
rat lowest published toxic dose: 19.31 痢/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other CJPPA3 63,1537,1985
intraperitoneal
rat lowest published toxic dose: 20 痢/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases BCPCA6 39,485,1990
intraperitoneal
rat lowest published toxic dose: 80 痢/kg Related to Chronic Data: Changes in uterine weight BCPCA6 39,485,1990
intraperitoneal
rat lowest published toxic dose: 100 痢/kg Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 37,51,1985
intraperitoneal
rabbit lethal dose (50 percent kill): 252 痢/kg N/R SCAMAC 254,29,1986
oral
chicken lowest published lethal dose: 25 痢/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTXAV 11,585,1973
oral
dog lethal dose (50 percent kill): 1 痢/kg N/R EXPEAM 38,879,1982
oral
frog lethal dose (50 percent kill): 1 mg/kg N/R SCAMAC 254,29,1986
oral
guinea pig lethal dose (50 percent kill): 500 ng/kg N/R EVSRBT 2,708,1973
oral
hamster lethal dose (50 percent kill): 1,157 痢/kg Gastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 55,67,1980
oral
hamster lethal dose (50 percent kill): 5,051 痢/kg N/R TAEHC* VI:88 ,1,1989
oral
mammal (species unspecified) lethal dose (50 percent kill): 4,200 ng/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen AECTCV 17,33,1988
oral
monkey lethal dose (50 percent kill): 2 痢/kg N/R EXPEAM 38,879,1982
oral
monkey lowest published toxic dose: 0.4 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders REPTED 15,377,2001
oral
mouse lethal dose (50 percent kill): 114 痢/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes TXAPA9 29,229,1974
oral
mouse lowest published toxic dose: 10 痢/kg Behavioral: Change in motor activity (specific assay) TOSCF2 56,114,2000
oral
mouse lowest published toxic dose: 50 痢/kg Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other NRTXDN 23,783,2002
oral
mouse lowest published toxic dose: 400 痢/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXAPA9 190,120,2003
oral
mouse lowest published toxic dose: 4,000 痢/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXAPA9 190,120,2003
oral
mouse lowest published toxic dose: 50 痢/kg Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins TXAPA9 192,262,2003
oral
mouse lowest published toxic dose: 10 痢/kg Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXAPA9 192,275,2003
oral
mouse lowest published toxic dose: 0.3 痢/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 72(Suppl 1),403,2003
oral
mouse lowest published toxic dose: 0.3 痢/kg Liver: Changes in liver weight TOXID9 72(Suppl 1),403,2003
oral
mouse lowest published toxic dose: 5 痢/kg Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXCYAC 172,49,2002
oral
mouse lowest published toxic dose: 20 痢/kg Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXCYAC 172,49,2002
oral
mouse lowest published toxic dose: 156 痢/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 72(Suppl 1),363,2003
oral
mouse lowest published toxic dose: 0.1 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72(Suppl 1),364,2003
oral
mouse lowest published toxic dose: 5 痢/kg Liver: Other changes

Blood: Other changes TOXID9 72(Suppl 1),364,2003
oral
mouse lowest published toxic dose: 12.5 痢/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 175,73,2002
oral
mouse lowest published toxic dose: 5 痢/kg Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXCYAC 188,15,2003
oral
mouse lowest published toxic dose: 20 痢/kg Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response TOSCF2 66,117,2002
oral
rat lethal dose (50 percent kill): 20 痢/kg N/R EXPEAM 38,879,1982
oral
rat lowest published toxic dose: 50 痢/kg Endocrine: Adrenal cortex hypoplasia

Endocrine: Other changes NETEEC 15,365,1993
oral
rat lowest published toxic dose: 90 痢/kg Endocrine: Changes in spleen weight TXCYAC 106,221,1996
oral
rat lowest published toxic dose: 10 痢/kg Immunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 106,221,1996
oral
rat lowest published toxic dose: 1 痢/kg Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 106,221,1996
oral
rat lowest published toxic dose: 5 痢/kg Endocrine: Changes in thymus weight TXAPA9 128,97,1994
oral
rat lowest published toxic dose: 0.3 痢/kg Endocrine: Change in LH

Endocrine: Change in gonadotropins TXAPA9 142,264,1997
oral
rat lowest published toxic dose: 1 痢/kg Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Metabolism (intermediary): Other proteins LIFSAK 69,1291,2001
oral
rat lowest published toxic dose: 2 痢/kg Nutritional and Gross Metabolic: Changes in: Fe LIFSAK 69,1291,2001
oral
rat lowest published toxic dose: 4 痢/kg Nutritional and Gross Metabolic: Changes in: Other metals LIFSAK 69,1291,2001
oral
rat lowest published toxic dose: 1 痢/kg Vascular: BP elevation not characterized in autonomic section

Cardiac: Pulse rate decreased with fall in BP

Nutritional and Gross Metabolic: Body temperature decrease TXCYAC 145,227,2000
oral
rat lowest published toxic dose: 0.2 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) EVHPAZ 5,199,1973
oral
rat lowest published toxic dose: 1 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) EVHPAZ 5,199,1973
oral
rat lowest published toxic dose: 50 痢/kg Endocrine: Change in LH

Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct BIREBV 45,143,1991
oral
rat lowest published toxic dose: 100 痢/kg Endocrine: Androgenic TXAPA9 105,78,1990
oral
rat lowest published toxic dose: 6.25 痢/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Respiratory depression

Endocrine: Other changes TXAPA9 84,45,1986
oral
rat lowest published toxic dose: 12.5 痢/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 84,45,1986
oral
rat lowest published toxic dose: 25 痢/kg Endocrine: Other changes BCPCA6 33,2531,1984
oral
rat lowest published toxic dose: 10 痢/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) JPETAB 215,601,1980
oral
rat lowest published toxic dose: 12.5 mg/kg Endocrine: Androgenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other BCPCA6 36,727,1987
oral
rat lowest published toxic dose: 25 痢/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) BCPCA6 31,3663,1982
oral
rat lowest published toxic dose: 50 痢/kg Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other BCPCA6 35,4359,1986
oral
rat lowest published toxic dose: 100 痢/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands TXAPA9 106,112,1990
oral
rat lowest published toxic dose: 0.1 mg/kg Reproductive: Maternal effects: Oogenesis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight TXAPA9 133,321,1995
oral
rat lowest published toxic dose: 10 痢/kg Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 78,219,1995
oral
rat lowest published toxic dose: 50 痢/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CRTOEC 13,1051,2000
oral
rat lowest published toxic dose: 2.5 痢/kg Skin and Appendages: Other: Breast

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens EVHPAZ 109,739,2001
oral
rat lowest published toxic dose: 0.14 痢/kg Liver: Other changes TXAPA9 187,128,2003
oral
rat lowest published toxic dose: 0.83 痢/kg Liver: Other changes

Endocrine: Changes in thymus weight TXAPA9 187,128,2003
oral
rat lowest published toxic dose: 5.5 痢/kg Liver: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 187,128,2003
oral
rat lowest published toxic dose: 0.77 痢/kg Endocrine: Evidence of thyroid hypofunction TXAPA9 181,38,2002
oral
rat lowest published toxic dose: 2.3 痢/kg Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thymus weight TXAPA9 181,38,2002
oral
rat lowest published toxic dose: 6.3 痢/kg Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 181,38,2002
oral
rat lowest published toxic dose: 1 痢/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 171,73,2002
oral
rat lowest published toxic dose: 4 痢/kg Liver: Other changes

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 171,73,2002
oral
rat lowest published toxic dose: 50 痢/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72(Suppl 1),361,2003
oral
rat lowest published toxic dose: 300 痢/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes TOSCF2 71,112,2003
oral
rat lowest published toxic dose: 10 痢/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases CBINA8 145,1,2003
oral
rat lowest published toxic dose: 1 痢/kg Kidney, Ureter, and Bladder: Other changes CBINA8 145,1,2003
oral
rat lowest published toxic dose: 0.1 痢/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other CBINA8 145,1,2003
oral
rabbit lethal dose (50 percent kill): 115 痢/kg N/R TXAPA9 35,553,1976
subcutaneous
rat lowest published toxic dose: 20 痢/kg Liver: Changes in liver weight TXAPA9 133,313,1995
subcutaneous
rat lowest published toxic dose: 40 痢/kg Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 133,313,1995
subcutaneous
rat lowest published toxic dose: 2,500 ng/kg Endocrine: Other changes JDPHDH 15,337,1991
subcutaneous
rat lowest published toxic dose: 2,500 ng/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JDPHDH 15,337,1991
skin
human lowest published toxic dose: 107 痢/kg Skin: After topical application: Dermatitis, allergic SCAMAC 254,29,1986
skin
monkey lowest published toxic dose: 10 ng/kg Blood: Other changes

Blood: Changes in leukocyte (WBC) count TAEHC* VI:205,1,1998
skin
mouse lowest published lethal dose: 80 痢/kg Gastrointestinal: Other changes RCOCB8 20,101,1978
skin
rabbit lethal dose (50 percent kill): 275 痢/kg N/R EVHPAZ 5,87,1973
unreported route
human lowest published toxic dose: 25 痢/kg Gastrointestinal: Nausea or vomiting

Blood: Normocytic anemia

Skin: After systemic exposure: Dermatitis, other EVHPAZ 109,865,2001
unreported route
human lowest published toxic dose: 6 痢/kg Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other

Biochemical: Metabolism (intermediary): Lipids including transport EVHPAZ 109,865,2001
unreported route
mouse lowest published lethal dose: 200 痢/kg Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain ANYAA9 320,204,1979
unreported route
mouse lowest published toxic dose: 0.32 痢/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 72,109,2003
unreported route
mouse lowest published toxic dose: 8 痢/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes TOXID9 72,109,2003
unreported route
rat lethal dose (50 percent kill): 0.25 mg/kg N/R TXAPA9 133,321,1995
unreported route
rat lowest published lethal dose: 19 痢/kg N/R TXAPA9 187,128,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 9,260 ng/kg/4 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count TOLED5 60,247,1992
intraperitoneal
mouse lowest published toxic dose: 180 痢/kg/6 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases CMSHAF 14,949,1985
intraperitoneal
mouse lowest published toxic dose: 120 痢/kg/12 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in other cell count (unspecified) CMSHAF 19,927,1989
intraperitoneal
rat lowest published toxic dose: 240 ng/kg/8 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases TXCYAC 171,117,2002
oral
guinea pig lowest published toxic dose: 441 ng/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 6,454,1986
oral
guinea pig lowest published toxic dose: 1,600 ng/kg/8 week- intermittent Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain EVHPAZ 5,101,1973
oral
guinea pig lowest published toxic dose: 5 痢/kg/5 week- intermittent Endocrine: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 5,125,1973
oral
hamster lowest published toxic dose: 600 痢/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases BECTA6 31,649,1983
oral
mammal (species unspecified) lowest published toxic dose: 1.68 痢/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,22,2001
oral
mammal (species unspecified) lowest published toxic dose: 3.36 痢/kg/28 day- continuous Musculoskeletal: Changes in teeth and supporting structures

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VHTODE 43,22,2001
oral
mammal (species unspecified) lowest published toxic dose: 3.92 痢/kg/4 week- continuous Behavioral: Somnolence (general depressed activity) VHTODE 43,134,2001
oral
mammal (species unspecified) lowest published toxic dose: 4.76 痢/kg/34 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VHTODE 43,134,2001
oral
mammal (species unspecified) lowest published toxic dose: 18.48 痢/kg/132 day- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,134,2001
oral
mammal (species unspecified) lowest published toxic dose: 211.2 ng/kg/132 day- continuous Blood: Other changes

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Nutritional and Gross Metabolic: Changes in: Fe VHTODE 43,134,2001
oral
monkey lowest published toxic dose: 10 痢/kg/12 day- continuous Gastrointestinal: Ulceration or bleeding from stomach

Nutritional and Gross Metabolic: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 18,108,1977
oral
monkey lowest published toxic dose: 2.143 痢/kg/120 day- intermittent Immunological Including Allergic: Decreased immune response TOSCF2 56,374,2000
oral
monkey lowest published toxic dose: 170.4 痢/kg/240 day- intermittent Reproductive: Other effects on female TOSCF2 56,374,2000
oral
monkey lowest published toxic dose: 5.35 痢/kg/30 week- continuous Endocrine: Estrogenic

Endocrine: Other changes ANYAA9 -,419,1979
oral
monkey lowest published toxic dose: 0.535 痢/kg/30 week- continuous Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Maternal effects: Parturition ANYAA9 -,419,1979
oral
mouse lowest published toxic dose: 588 痢/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight TXAPA9 112,128,1992
oral
mouse lowest published toxic dose: 20 痢/kg/4 week- intermittent Endocrine: Other changes

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response EVHPAZ 5,149,1973
oral
mouse lowest published toxic dose: 520 痢/kg/13 week- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-209,1982
oral
mouse lowest published toxic dose: 336 痢/kg/8 week- continuous Blood: Other changes

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in humoral immune response JEPTDQ 4(2-3),401,1980
oral
mouse lowest published toxic dose: 150 痢/kg/6 week- intermittent Liver: Fatty liver degeneration

Endocrine: Changes in thymus weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TXAPA9 29,229,1974
oral
mouse lowest published toxic dose: 97.5 ng/kg/13 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation TXAPA9 124,82,1994
oral
mouse lowest published toxic dose: 12 痢/kg/4 day- intermittent Liver: Changes in liver weight TJADAB 33,29,1986
oral
mouse lowest published toxic dose: 50 痢/kg/15 week- intermittent Liver: Changes in liver weight

Tumorigenic: Increased incidence of tumors in susceptible strains

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) EVHPAZ 105,750,1997
oral
rat lowest published toxic dose: 30 痢/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects EVHPAZ 5,111,1973
oral
rat lowest published toxic dose: 6,500 ng/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Pigmented or nucleated red blood cells TXAPA9 35,553,1976
oral
rat lowest published toxic dose: 7,300 mg/kg/2 year- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition TXAPA9 46(2),279,1978
oral
rat lowest published toxic dose: 16 痢/kg/16 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments BCPCA6 31,1607,1982
oral
rat lowest published toxic dose: 120 痢/kg/3 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BECTA6 45,436,1990
oral
rat lowest published toxic dose: 450 ng/kg/45 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TXAPA9 57,156,1981
oral
rat lowest published toxic dose: 140 痢/kg/14 day- intermittent Blood: Change in clotting factors

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count EVHPAZ 5,119,1973
oral
rat lowest published toxic dose: 3 痢/kg/80 day- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response EJPHAZ 293,429,1995
oral
rat lowest published toxic dose: 2.9 痢/kg/30 day- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response EJPHAZ 293,429,1995
oral
rat lowest published toxic dose: 70 痢/kg/13 week- intermittent Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field CMSHAF 29,2381,1994
oral
rat lowest published toxic dose: 41.9 痢/kg/13 week- intermittent Blood: Changes in platelet count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 146,217,1997
oral
rat lowest published toxic dose: 7,000 ng/kg/28 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport CMSHAF 43,807,2001
oral
rat lowest published toxic dose: 28,000 ng/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight

Blood: Microcytosis with or without anemia CMSHAF 43,807,2001
oral
rat lowest published toxic dose: 22.75 痢/kg/91 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain CMSHAF 25,2023,1992
oral
rat lowest published toxic dose: 2.275 痢/kg/91 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) CMSHAF 25,2023,1992
oral
rat lowest published toxic dose: 10 痢/kg/7 day- intermittent Skin and Appendages: Other: Breast

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight EVHPAZ 103,708,1995
oral
rat lowest published toxic dose: 2.9 痢/kg/30 day- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response EPEPEG 293,429,1995
oral
rat lowest published toxic dose: 3 痢/kg/180 day- continuous Immunological Including Allergic: Decrease in cellular immune response EPEPEG 293,429,1995
oral
rat lowest published toxic dose: 13 痢/kg/13 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other BCPCA6 32,991,1983
oral
rat lowest published toxic dose: 7 痢/kg/4 week- continuous Endocrine: Evidence of thyroid hypofunction CMSHAF 25,1239,1992
oral
rat lowest published toxic dose: 0.7 痢/kg/4 week- continuous Biochemical: Metabolism (intermediary): Other CMSHAF 25,1239,1992
oral
rat lowest published toxic dose: 2.275 痢/kg/13 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency CMSHAF 25,1239,1992
oral
rat lowest published toxic dose: 105 痢/kg/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,22,2001
oral
rat lowest published toxic dose: 45 ng/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight JJATDK 22,345,2002
oral
rat lowest published toxic dose: 72.8 痢/kg/2 year- intermittent Cardiac: Cardiomyopathy including infarction

Vascular: Structural changes in vessels

Liver: Other changes TOXID9 72,30,2003
oral
rat lowest published toxic dose: 900 ng/kg/90 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes TOXID9 72,77,2003
oral
rat lowest published toxic dose: 45 ng/kg/45 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Related to Chronic Data: Changes in testicular weight JAPTO* 22,345,2002
oral
rat lowest published toxic dose: 45 ng/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Related to Chronic Data: Changes in prostate weight JAPTO* 22,345,2002
oral
rat lowest published toxic dose: 450 ng/kg/30 week- intermittent Brain and Coverings: Other degenerative changes JJTHEC 65,825,2002
oral
rat lowest published toxic dose: 3,300 ng/kg/30 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJTHEC 65,825,2002
oral
rat lowest published toxic dose: 3,500 ng/kg/5 week- intermittent Liver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects TXAPA9 191,12,2003
oral
rat lowest published toxic dose: 45 ng/kg/45 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport

Related to Chronic Data: Changes in testicular weight TXCYAC 171,127,2002
oral
rat lowest published toxic dose: 3,000 ng/kg/60 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight TOXID9 72,362,2003
oral
rat lowest published toxic dose: 0.7 痢/kg/28 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins TXCYAC 178,45,2002
oral
rat lowest published toxic dose: 275 ng/kg/64 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins TOXID9 72,361,2003
oral
rabbit lowest published toxic dose: 80 痢/kg/8 week- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0544117
subcutaneous
rat lowest published toxic dose: 3,500 ng/kg/5 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Tumorigenic: Cells (cultured) transformed CRNGDP 15,1143,1994
subcutaneous
rat lowest published toxic dose: 6,300 ng/kg/9 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases CRNGDP 15,1143,1994
subcutaneous
rat lowest published toxic dose: 140 ng/kg/20 week- intermittent Liver: Other changes TOXID9 72,363,2003
subcutaneous
rat lowest published toxic dose: 17 痢/kg/19 week- intermittent Musculoskeletal: Changes in teeth and supporting structures TOSCF2 69,482,2002
subcutaneous
rat lowest published toxic dose: 170 痢/kg/19 week- intermittent Vascular: Structural changes in vessels

Musculoskeletal: Changes in teeth and supporting structures TOSCF2 69,482,2002
skin
mouse lowest published toxic dose: 97 痢/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NCITR* NCI-TR-201-82
skin
mouse lowest published toxic dose: 8 mg/kg/20 week- intermittent Liver: Changes in liver weight

Skin: After systemic exposure: Dermatitis, other

Tumorigenic: Facilitates action of known carcinogens TXAPA9 102,362,1990
skin
mouse lowest published toxic dose: 200 痢/kg/20 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight

Liver: Fatty liver degeneration FCTOD7 42,1217,2004
skin
mouse lowest published toxic dose: 200 ng/kg/1 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FCTOD7 42,1217,2004
skin
mouse lowest published toxic dose: 300 ng/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) FCTOD7 42,1217,2004
skin
mouse lowest published toxic dose: 15 痢/kg/3 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport FCTOD7 42,1217,2004
unreported route
mouse lowest published toxic dose: 5.5 痢/kg/14 day- intermittent Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) TOXID9 72,121,2003
unreported route
mouse lowest published toxic dose: 15 痢/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) TOXID9 72,230,2003
unreported route
rat lowest published toxic dose: 9,100 ng/kg/13 week- intermittent Liver: Other changes TOXID9 72,264,2003

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 69,33,1997
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,41,1977
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMSUDL 7,350,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 69,33,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 69,33,1997
TOXICOLOGY REVIEW
RREVAH 59,1,1975
TOXICOLOGY REVIEW
ARPAAQ 94,125,1972
TOXICOLOGY REVIEW
CHRYAQ 47(2),15,1974
TOXICOLOGY REVIEW
TXCYAC 3,187,1975
TOXICOLOGY REVIEW
RPZHAW 26,623,1975
TOXICOLOGY REVIEW
BIOGAL 40(2),44,1974
TOXICOLOGY REVIEW
STEVA8 2,305,1974
TOXICOLOGY REVIEW
EVHPAZ 15,121,1976
TOXICOLOGY REVIEW
FCTXAV 17,95,1979
TOXICOLOGY REVIEW
PHTHDT 7,513,1979
TOXICOLOGY REVIEW
MUREAV 47,141,1978
TOXICOLOGY REVIEW
ARTODN 40,161,1978
TOXICOLOGY REVIEW
EVSRBT 2,708,1973
TOXICOLOGY REVIEW
NTIS PB82-922905
TOXICOLOGY REVIEW
MEPAAX 29,59,1978
TOXICOLOGY REVIEW
VHTODE 22,31,1980
TOXICOLOGY REVIEW
MGLFDB -,123,1978
TOXICOLOGY REVIEW
FCTOD7 25,257,1987
TOXICOLOGY REVIEW
ARPTDI 22,517,1982
TOXICOLOGY REVIEW
ARPTDI 43,309,2003
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
TOLED5 140-141,3,2003
TOXICOLOGY REVIEW
MUREAV 5611472004
TOXICOLOGY REVIEW
ARTODN 44,211,1980
TOXICOLOGY REVIEW
DMTRAR 13,387,1982

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE**

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TCDD-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7301;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 14;
Total Number of Female Employees Exposed 5

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/89/214522/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 40, 1984
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NCI Carcinogenesis Bioassay (dermal);clear evidence:mouse NCITR* NCI-TR-201,1982
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000

REFERENCES:
CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BESCE5 Biomedical and Environmental Sciences. (Academic Press, 525 B St., Suite 1900, San Diego, CA 92101) V.1- 1988-
BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252, CEP 04014, Sao Paulo, Brazil) V.1- 1935-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV.
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CHRYAQ Chemistry. (Washington, DC) V.18-52, 1944-79.
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DMTRAR Drug Metabolism Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1972-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EPEPEG European Journal of Pharmacology, Environmental Toxicology and Pharmacology Section. (Elsevier Science Publishers B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.228- 1992-
ETOCDK Environmental Toxicology and Chemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1982-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJIMDS International Journal of Immunopharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JDPHDH Journal of Developmental Physiology. (Oxford University Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
LPDSAP Lipids. (American Oil Chemists' Soc., POB 5037, Stn. A., Champaign, IL 61820) V.1- 1966-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MGLFDB Monographs of the Giovanni Lorenzini Foundation. (New York, NY) V.1, 1978. Discontinued.
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR.
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.4- 1979-
PSSID2 Pergamon Series on Environmental Science. (Oxford, UK) V.1-7, 1978-82. Discontinued.
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SCAMAC Scientific American. (Scientific American, Inc., 415 Madison Ave., New York, NY 10017) V.1- 1859-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TAEHC* Environmental Health Criteria (United Nations Environment Programme. Geneva, World Health Organization) 1- 1976-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 56795-67-6
Click Here for Additional Information about RTECS

SYNONYMS:
2,3,7,8 - Czterochlorodwubenzo - p - dwuoksyny (Polish) 2,3,7,8 - TCDD 2,3,7,8 - Tetrachlorodibenzo (b,e) (1,4) dioxan 2,3,7,8 - Tetrachlorodibenzo - 1,4 - dioxin 2,3,7,8 - Tetrachlorodibenzo - p - dioxin 2,3,7,8 - Tetrachlorodibenzo - p - dioxin (TCDD) Dibenzo (b,e) (1,4) dioxin, 2,3,7,8 - tetrachloro - Dioksyny (Polish)	Dioxin Dioxin (herbicide contaminant) Dioxine NCI - C03714 TCDBD TCDD Tetradioxin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	2 mg	moderate	EVHPAZ 5,87,1973

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	oral mouse	100 痢/kg	TXAPA9 29,229,1974
cytogenetic analysis	intraperitoneal mouse	10 痢/kg	PSSID2 5,419,1982
cytogenetic analysis	oral rat	100 痢/kg	MUREAV 47,141,1978
cytogenetic analysis	intraperitoneal rat	10 mg/kg	MUREAV 47,141,1978
DNA adduct	intraperitoneal rat	40 痢/kg/4 week- intermittent	CMSHAF 25,975,1992
DNA adduct	oral rat	0.21 mg/kg/30 week- intermittent	CRTOEC 14,849,2001
DNA damage	mouse other cell types	10 nmol/L/24 hour	TOLED5 145,55,2003
DNA damage	oral rat	100 痢/kg	CALEDQ 39,281,1988
DNA damage	unreported route rat	100 痢/kg	CALEDQ 29,281,1988
DNA damage	oral rat	450 ng/kg/30 week- intermittent	JJTHEC 65,825,2002
DNA inhibition	human other cell types	10 nmol/L	TXAPA9 77,434,1985
DNA inhibition	intraperitoneal mouse	400 痢/kg	MUREAV 46,305,1977
DNA inhibition	intraperitoneal rat	10 痢/kg	CBINA8 8,31,1974
DNA inhibition	oral rat	200 痢/kg	CBINA8 8,31,1974
unscheduled DNA synthesis	human other cell types	100 pmol/L	CRNGDP 11,1335,1990
unscheduled DNA synthesis	oral mouse	800 pmol/kg	CRNGDP 8,1433,1987
unscheduled DNA synthesis	intravenous rat	4 痢/kg	BCPCA6 31,2459,1982
unscheduled DNA synthesis	oral rat	5 痢/kg	TXCYAC 28,133,1983
host-mediated assay	mouse Saccharomyes cerevisiae	25 痢/kg	CMSHAF 12,549,1983
mutation in microorganisms	Escherichia coli	2 mg/L (-enzymatic activation step)	AMBOCX 1,1,1972
mutation in microorganisms	Salmonella typhimurium	2 mg/L (+enzymatic activation step)	AMBOCX 1,32,1972
mutation in microorganisms	Saccharomyes cerevisiae	10 mg/L (-enzymatic activation step)	CMSHAF 12,549,1983
mutation in microorganisms	Saccharomyes cerevisiae	2 mg/L (+enzymatic activation step)	PSSID2 5,429,1982
gene conversion and mitotic recombination	hamster ovary	0.5 nmol/L/24 hour	TOXID9 72,369,2003
gene conversion and mitotic recombination	Saccharomyes cerevisiae	10 mg/L	CMSHAF 12,549,1983
mutation in mammalian somatic cells	mouse lymphocyte	50 mg/L	ENMUDM 4,391,1982
morphological transform	mouse fibroblast	200 nmol/L	ENMUDM 6,461,1984
morphological transform	mouse fibroblast	10 nmol/L/21 day (-enzymatic activation step)	EMMUEG 37,231,2001
other mutation test systems	mouse other cell types	1 nmol/L	JBCHA3 259,12357,1984
other mutation test systems	oral mouse	50 痢/kg	TXCYAC 56,239,1989
phage inhibition capacity	Escherichia coli	500 痢/L	AMBOCX 1,1,1972

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 1.61 痢/kg	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Facilitates action of known carcinogens	TXAPA9 179,21,2002
oral mouse	lowest published toxic dose: 52 痢/kg/2 year- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Thyroid tumors	NTPTR* NTP-TR-209,1982
oral mouse	toxic dose : 1 痢/kg/2 year- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Endocrine: Thyroid tumors	NTPTR* NTP-TR-209,1982
oral mouse	toxic dose : 36 痢/kg/52 week- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	NATUAS 278,548,1979
oral mouse	lowest published toxic dose: 0.52 mg/kg/104 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB82-163445
oral mouse	lowest published toxic dose: 0.208 mg/kg/104 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Thyroid tumors	NTIS** PB82-163445
oral rat	lowest published toxic dose: 52 痢/kg/2 year- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Thyroid tumors	NTPTR* NTP-TR-209,1982
oral rat	toxic dose : 328 痢/kg/78 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	PESTC* 5,12,1977
oral rat	toxic dose : 137 痢/kg/65 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors	FEPRA7 36,396,1977
oral rat	toxic dose : 73 痢/kg/2 year- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	ANYAA9 320,397,1979
oral rat	toxic dose : 1 痢/kg/2 year- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Endocrine: Thyroid tumors	NTPTR* NTP-TR-209,1982
oral rat	lowest published toxic dose: 164 痢/kg/78 week- continuous	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	CMSHAF 6,625,1977
oral rat	toxic dose : 190 痢/kg/95 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	CMSHAF 6,537,1977
oral rat	toxic dose : 27 痢/kg/65 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors	FEPRA7 36,396,1977
oral rat	lowest published toxic dose: 0.52 mg/kg/104 week- intermittent	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Thyroid tumors	NTIS** PB82-163445
oral rat	lowest published toxic dose: 0.52 mg/kg/104 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB82-163445
skin mouse	lowest published toxic dose: 62 痢/kg/2 year- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors	NCITR* NCI-TR-201,1982
skin mouse	toxic dose : 80 痢/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	BECTA6 18,552,1977
skin mouse	lowest published toxic dose: 0.594 mg/kg/99 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors	NTIS** PB82-163684
skin mouse	lowest published toxic dose: 0.1,188 mg/kg/99 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	NTIS** PB82-163684

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 9,260 ng/kg/4 week- intermittent	Liver: Changes in liver weight Endocrine: Changes in thymus weight Blood: Changes in erythrocyte (RBC) count	TOLED5 60,247,1992
intraperitoneal mouse	lowest published toxic dose: 180 痢/kg/6 week- intermittent	Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	CMSHAF 14,949,1985
intraperitoneal mouse	lowest published toxic dose: 120 痢/kg/12 week- intermittent	Liver: Changes in liver weight Endocrine: Changes in thymus weight Blood: Changes in other cell count (unspecified)	CMSHAF 19,927,1989
intraperitoneal rat	lowest published toxic dose: 240 ng/kg/8 week- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	TXCYAC 171,117,2002
oral guinea pig	lowest published toxic dose: 441 ng/kg/90 day- continuous	Liver: Changes in liver weight Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 6,454,1986
oral guinea pig	lowest published toxic dose: 1,600 ng/kg/8 week- intermittent	Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	EVHPAZ 5,101,1973
oral guinea pig	lowest published toxic dose: 5 痢/kg/5 week- intermittent	Endocrine: Other changes Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	EVHPAZ 5,125,1973
oral hamster	lowest published toxic dose: 600 痢/kg/3 day- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	BECTA6 31,649,1983
oral mammal (species unspecified)	lowest published toxic dose: 1.68 痢/kg/14 day- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VHTODE 43,22,2001
oral mammal (species unspecified)	lowest published toxic dose: 3.36 痢/kg/28 day- continuous	Musculoskeletal: Changes in teeth and supporting structures Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VHTODE 43,22,2001
oral mammal (species unspecified)	lowest published toxic dose: 3.92 痢/kg/4 week- continuous	Behavioral: Somnolence (general depressed activity)	VHTODE 43,134,2001
oral mammal (species unspecified)	lowest published toxic dose: 4.76 痢/kg/34 day- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VHTODE 43,134,2001
oral mammal (species unspecified)	lowest published toxic dose: 18.48 痢/kg/132 day- continuous	Brain and Coverings: Other degenerative changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VHTODE 43,134,2001
oral mammal (species unspecified)	lowest published toxic dose: 211.2 ng/kg/132 day- continuous	Blood: Other changes Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Nutritional and Gross Metabolic: Changes in: Fe	VHTODE 43,134,2001
oral monkey	lowest published toxic dose: 10 痢/kg/12 day- continuous	Gastrointestinal: Ulceration or bleeding from stomach Nutritional and Gross Metabolic: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BECTA6 18,108,1977
oral monkey	lowest published toxic dose: 2.143 痢/kg/120 day- intermittent	Immunological Including Allergic: Decreased immune response	TOSCF2 56,374,2000
oral monkey	lowest published toxic dose: 170.4 痢/kg/240 day- intermittent	Reproductive: Other effects on female	TOSCF2 56,374,2000
oral monkey	lowest published toxic dose: 5.35 痢/kg/30 week- continuous	Endocrine: Estrogenic Endocrine: Other changes	ANYAA9 -,419,1979
oral monkey	lowest published toxic dose: 0.535 痢/kg/30 week- continuous	Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Maternal effects: Parturition	ANYAA9 -,419,1979
oral mouse	lowest published toxic dose: 588 痢/kg/14 day- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight	TXAPA9 112,128,1992
oral mouse	lowest published toxic dose: 20 痢/kg/4 week- intermittent	Endocrine: Other changes Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in cellular immune response	EVHPAZ 5,149,1973
oral mouse	lowest published toxic dose: 520 痢/kg/13 week- intermittent	Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-209,1982
oral mouse	lowest published toxic dose: 336 痢/kg/8 week- continuous	Blood: Other changes Blood: Changes in leukocyte (WBC) count Immunological Including Allergic: Decrease in humoral immune response	JEPTDQ 4(2-3),401,1980
oral mouse	lowest published toxic dose: 150 痢/kg/6 week- intermittent	Liver: Fatty liver degeneration Endocrine: Changes in thymus weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TXAPA9 29,229,1974
oral mouse	lowest published toxic dose: 97.5 ng/kg/13 week- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	TXAPA9 124,82,1994
oral mouse	lowest published toxic dose: 12 痢/kg/4 day- intermittent	Liver: Changes in liver weight	TJADAB 33,29,1986
oral mouse	lowest published toxic dose: 50 痢/kg/15 week- intermittent	Liver: Changes in liver weight Tumorigenic: Increased incidence of tumors in susceptible strains Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	EVHPAZ 105,750,1997
oral rat	lowest published toxic dose: 30 痢/kg/30 day- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in platelet count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	EVHPAZ 5,111,1973
oral rat	lowest published toxic dose: 6,500 ng/kg/13 week- intermittent	Liver: Changes in liver weight Endocrine: Changes in thymus weight Blood: Pigmented or nucleated red blood cells	TXAPA9 35,553,1976
oral rat	lowest published toxic dose: 7,300 mg/kg/2 year- continuous	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition	TXAPA9 46(2),279,1978
oral rat	lowest published toxic dose: 16 痢/kg/16 week- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments	BCPCA6 31,1607,1982
oral rat	lowest published toxic dose: 120 痢/kg/3 day- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	BECTA6 45,436,1990
oral rat	lowest published toxic dose: 450 ng/kg/45 week- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	TXAPA9 57,156,1981
oral rat	lowest published toxic dose: 140 痢/kg/14 day- intermittent	Blood: Change in clotting factors Blood: Changes in erythrocyte (RBC) count Blood: Changes in platelet count	EVHPAZ 5,119,1973
oral rat	lowest published toxic dose: 3 痢/kg/80 day- continuous	Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response	EJPHAZ 293,429,1995
oral rat	lowest published toxic dose: 2.9 痢/kg/30 day- continuous	Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response	EJPHAZ 293,429,1995
oral rat	lowest published toxic dose: 70 痢/kg/13 week- intermittent	Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	CMSHAF 29,2381,1994
oral rat	lowest published toxic dose: 41.9 痢/kg/13 week- intermittent	Blood: Changes in platelet count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 146,217,1997
oral rat	lowest published toxic dose: 7,000 ng/kg/28 day- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport	CMSHAF 43,807,2001
oral rat	lowest published toxic dose: 28,000 ng/kg/28 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Liver: Changes in liver weight Blood: Microcytosis with or without anemia	CMSHAF 43,807,2001
oral rat	lowest published toxic dose: 22.75 痢/kg/91 day- continuous	Liver: Changes in liver weight Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	CMSHAF 25,2023,1992
oral rat	lowest published toxic dose: 2.275 痢/kg/91 day- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	CMSHAF 25,2023,1992
oral rat	lowest published toxic dose: 10 痢/kg/7 day- intermittent	Skin and Appendages: Other: Breast Related to Chronic Data: Changes in ovarian weight Related to Chronic Data: Changes in uterine weight	EVHPAZ 103,708,1995
oral rat	lowest published toxic dose: 2.9 痢/kg/30 day- continuous	Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in cellular immune response	EPEPEG 293,429,1995
oral rat	lowest published toxic dose: 3 痢/kg/180 day- continuous	Immunological Including Allergic: Decrease in cellular immune response	EPEPEG 293,429,1995
oral rat	lowest published toxic dose: 13 痢/kg/13 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other	BCPCA6 32,991,1983
oral rat	lowest published toxic dose: 7 痢/kg/4 week- continuous	Endocrine: Evidence of thyroid hypofunction	CMSHAF 25,1239,1992
oral rat	lowest published toxic dose: 0.7 痢/kg/4 week- continuous	Biochemical: Metabolism (intermediary): Other	CMSHAF 25,1239,1992
oral rat	lowest published toxic dose: 2.275 痢/kg/13 week- continuous	Liver: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency	CMSHAF 25,1239,1992
oral rat	lowest published toxic dose: 105 痢/kg/5 week- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VHTODE 43,22,2001
oral rat	lowest published toxic dose: 45 ng/kg/45 day- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	JJATDK 22,345,2002
oral rat	lowest published toxic dose: 72.8 痢/kg/2 year- intermittent	Cardiac: Cardiomyopathy including infarction Vascular: Structural changes in vessels Liver: Other changes	TOXID9 72,30,2003
oral rat	lowest published toxic dose: 900 ng/kg/90 day- intermittent	Brain and Coverings: Recordings from specific areas of CNS Brain and Coverings: Other degenerative changes	TOXID9 72,77,2003
oral rat	lowest published toxic dose: 45 ng/kg/45 day- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Related to Chronic Data: Changes in testicular weight	JAPTO* 22,345,2002
oral rat	lowest published toxic dose: 45 ng/kg/45 day- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Related to Chronic Data: Changes in prostate weight	JAPTO* 22,345,2002
oral rat	lowest published toxic dose: 450 ng/kg/30 week- intermittent	Brain and Coverings: Other degenerative changes	JJTHEC 65,825,2002
oral rat	lowest published toxic dose: 3,300 ng/kg/30 week- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	JJTHEC 65,825,2002
oral rat	lowest published toxic dose: 3,500 ng/kg/5 week- intermittent	Liver: Fatty liver degeneration Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	TXAPA9 191,12,2003
oral rat	lowest published toxic dose: 45 ng/kg/45 day- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport Related to Chronic Data: Changes in testicular weight	TXCYAC 171,127,2002
oral rat	lowest published toxic dose: 3,000 ng/kg/60 day- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	TOXID9 72,362,2003
oral rat	lowest published toxic dose: 0.7 痢/kg/28 day- intermittent	Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 178,45,2002
oral rat	lowest published toxic dose: 275 ng/kg/64 day- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins	TOXID9 72,361,2003
oral rabbit	lowest published toxic dose: 80 痢/kg/8 week- intermittent	Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0544117
subcutaneous rat	lowest published toxic dose: 3,500 ng/kg/5 week- intermittent	Liver: Other changes Liver: Changes in liver weight Tumorigenic: Cells (cultured) transformed	CRNGDP 15,1143,1994
subcutaneous rat	lowest published toxic dose: 6,300 ng/kg/9 week- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	CRNGDP 15,1143,1994
subcutaneous rat	lowest published toxic dose: 140 ng/kg/20 week- intermittent	Liver: Other changes	TOXID9 72,363,2003
subcutaneous rat	lowest published toxic dose: 17 痢/kg/19 week- intermittent	Musculoskeletal: Changes in teeth and supporting structures	TOSCF2 69,482,2002
subcutaneous rat	lowest published toxic dose: 170 痢/kg/19 week- intermittent	Vascular: Structural changes in vessels Musculoskeletal: Changes in teeth and supporting structures	TOSCF2 69,482,2002
skin mouse	lowest published toxic dose: 97 痢/kg/13 week- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NCITR* NCI-TR-201-82
skin mouse	lowest published toxic dose: 8 mg/kg/20 week- intermittent	Liver: Changes in liver weight Skin: After systemic exposure: Dermatitis, other Tumorigenic: Facilitates action of known carcinogens	TXAPA9 102,362,1990
skin mouse	lowest published toxic dose: 200 痢/kg/20 week- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Liver: Changes in liver weight Liver: Fatty liver degeneration	FCTOD7 42,1217,2004
skin mouse	lowest published toxic dose: 200 ng/kg/1 week- intermittent	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	FCTOD7 42,1217,2004
skin mouse	lowest published toxic dose: 300 ng/kg/3 day- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	FCTOD7 42,1217,2004
skin mouse	lowest published toxic dose: 15 痢/kg/3 day- intermittent	Biochemical: Metabolism (intermediary): Lipids including transport	FCTOD7 42,1217,2004
unreported route mouse	lowest published toxic dose: 5.5 痢/kg/14 day- intermittent	Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)	TOXID9 72,121,2003
unreported route mouse	lowest published toxic dose: 15 痢/kg/14 day- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)	TOXID9 72,230,2003
unreported route rat	lowest published toxic dose: 9,100 ng/kg/13 week- intermittent	Liver: Other changes	TOXID9 72,264,2003

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review	Animal Sufficient Evidence	IMEMDT 69,33,1997
International Agency for Research on Cancer (IARC) Cancer Review	Animal Inadequate Evidence	IMEMDT 15,41,1977
International Agency for Research on Cancer (IARC) Cancer Review	Human Sufficient Evidence	IMSUDL 7,350,1987
International Agency for Research on Cancer (IARC) Cancer Review	Human Limited Evidence	IMEMDT 69,33,1997
International Agency for Research on Cancer (IARC) Cancer Review	Group 1	IMEMDT 69,33,1997
TOXICOLOGY REVIEW		RREVAH 59,1,1975
TOXICOLOGY REVIEW		ARPAAQ 94,125,1972
TOXICOLOGY REVIEW		CHRYAQ 47(2),15,1974
TOXICOLOGY REVIEW		TXCYAC 3,187,1975
TOXICOLOGY REVIEW		RPZHAW 26,623,1975
TOXICOLOGY REVIEW		BIOGAL 40(2),44,1974
TOXICOLOGY REVIEW		STEVA8 2,305,1974
TOXICOLOGY REVIEW		EVHPAZ 15,121,1976
TOXICOLOGY REVIEW		FCTXAV 17,95,1979
TOXICOLOGY REVIEW		PHTHDT 7,513,1979
TOXICOLOGY REVIEW		MUREAV 47,141,1978
TOXICOLOGY REVIEW		ARTODN 40,161,1978
TOXICOLOGY REVIEW		EVSRBT 2,708,1973
TOXICOLOGY REVIEW		NTIS** PB82-922905
TOXICOLOGY REVIEW		MEPAAX 29,59,1978
TOXICOLOGY REVIEW		VHTODE 22,31,1980
TOXICOLOGY REVIEW		MGLFDB -,123,1978
TOXICOLOGY REVIEW		FCTOD7 25,257,1987
TOXICOLOGY REVIEW		ARPTDI 22,517,1982
TOXICOLOGY REVIEW		ARPTDI 43,309,2003
TOXICOLOGY REVIEW		TOLED5 134,3,2002
TOXICOLOGY REVIEW		TOLED5 138,9,2003
TOXICOLOGY REVIEW		TOLED5 140-141,3,2003
TOXICOLOGY REVIEW		MUREAV 5611472004
TOXICOLOGY REVIEW		ARTODN 44,211,1980
TOXICOLOGY REVIEW		DMTRAR 13,387,1982

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - AUSTRIA	Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND	Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE	Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY	Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND	Carcinogen, JAN1999

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TCDD-air	Carcinogen lowest feasible concentration	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X7301; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 14; Total Number of Female Employees Exposed 5

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/89/214522/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 40, 1984
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NCI Carcinogenesis Bioassay (dermal);clear evidence:mouse	NCITR* NCI-TR-201,1982
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000

REFERENCES:
CODEN	REFERENCE
AECTCV	Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMBOCX	Ambio. A Journal of the Human Environment. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
ANYAA9	Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARPAAQ	Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
ARPTDI	Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARTODN	Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG	Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
ATXKA8	Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BBRCA9	Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCPCA6	Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BECTA6	Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BESCE5	Biomedical and Environmental Sciences. (Academic Press, 525 B St., Suite 1900, San Diego, CA 92101) V.1- 1988-
BIOGAL	Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252, CEP 04014, Sao Paulo, Brazil) V.1- 1935-
BIREBV	Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BIRSB5	Biology of Reproduction, Supplement. (Champaign, IL) No.1-4, 1969-71(?). Discontinued. For publisher information, see BIREBV.
CALEDQ	Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8	Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CHRYAQ	Chemistry. (Washington, DC) V.18-52, 1944-79.
CJPPA3	Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CMSHAF	Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRNGDP	Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC	Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DCTODJ	Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DMTRAR	Drug Metabolism Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1972-
EJPHAZ	European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG	Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM	Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL	Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EPEPEG	European Journal of Pharmacology, Environmental Toxicology and Pharmacology Section. (Elsevier Science Publishers B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.228- 1992-
ETOCDK	Environmental Toxicology and Chemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1982-
ETOPFR	Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ	EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EVSRBT	Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
EXPEAM	Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FAATDF	Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7	Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HBPTO*	Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJIMDS	International Journal of Immunopharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979-
IMEMDT	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL	IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAPTO*	Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JBCHA3	Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JDPHDH	Journal of Developmental Physiology. (Oxford University Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979-
JEPTDQ	Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJATDK	JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJTHEC	Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6	Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LIFSAK	Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
LPDSAP	Lipids. (American Oil Chemists' Soc., POB 5037, Stn. A., Champaign, IL 61820) V.1- 1966-
MEPAAX	Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MGLFDB	Monographs of the Giovanni Lorenzini Foundation. (New York, NY) V.1, 1978. Discontinued.
MOPMA3	Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS	Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NCITR*	National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETEEC	Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN	Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR*	National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PESTC*	Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-
PHTHDT	Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.4- 1979-
PSSID2	Pergamon Series on Environmental Science. (Oxford, UK) V.1-7, 1978-82. Discontinued.
RCOCB8	Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
REPTED	Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPZHAW	Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RREVAH	Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SCAMAC	Scientific American. (Scientific American, Inc., 415 Madison Ave., New York, NY 10017) V.1- 1859-
STEVA8	Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TAEHC*	Environmental Health Criteria (United Nations Environment Programme. Geneva, World Health Organization) 1- 1976-
TCMUD8	Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB	Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2	Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VHTODE	Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-