The Registry of Toxic Effects of Chemical Substances

Dicyclohexylamine

RTECS #: HY4025000

CAS #: 101-83-7

UPDATE: July 2000 MW: 181.36 MF: C12H23N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. N - Cyclohexylcyclohexanamine
  2. DCHA
  3. Dicha
  1. N,N - Diclohexylamine
  2. Dodecahydrodiphenylamine
  3. Dicyklohexylamin (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg/24 hour severe 85JCAE -,468,1986
skin
rabbit 		2 mg/24 hour severe 85JCAE -,468,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human leukocyte 200 µg/L INHEAO 9,188,1971
DNA damage non-mammalian species 2 mmol/L MUREAV 368,181,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 40 gm/kg/52 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		VOONAW 4,659,1958
subcutaneous
mouse 		lowest published toxic dose: 2,404 mg/kg/48 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		VOONAW 4,659,1958


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R 85JCAE -,468,1986
oral
rat 		lethal dose (50 percent kill): 373 mg/kg N/R 85JCAE -,468,1986
subcutaneous
mouse 		lethal dose (50 percent kill): 135 mg/kg N/R VOONAW 4,659,1958
subcutaneous
rabbit 		lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold IECHAD 29,1247,1937


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 22,55,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 22,55,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,178,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1151;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 3;
Total Number of Employees Exposed 368
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1151;
Number of Industries 2;
Total Number of Facilities 40;
Number of Occupations 3;
Total Number of Employees Exposed 3,412;
Total Number of Female Employees Exposed 169


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as chemical intermediate for the synthesis of a variety of derivatives
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9219;8EHQ-0892-9270
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

Used as chemical intermediate for the synthesis of a variety of derivatives

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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