The Registry of Toxic Effects of Chemical Substances

Diethylamine

RTECS #: HZ8750000

CAS #: 109-89-7

UPDATE: November 2004 MW: 73.16 MF: C4H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. DEN
  2. Diaethylamin (German)
  3. Diethamine
  4. Dwuetyloamina (Polish)
  1. Ethanamine, N - ethyl -
  2. Diethylamine (ACGIH:OSHA)
  3. N,N - Diethylamine
  4. Dietilamina (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test mild UCDS** 5/21/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms other microorganisms 50 µL/plate (-enzymatic activation step) EJMBA2 16,133,1981
mutation in microorganisms other microorganisms 400 µL/plate (-enzymatic activation step) EJMBA2 15,113,1980
mutation in microorganisms other microorganisms 200 µL/plate (-enzymatic activation step) EJMBA2 15,113,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 5,000 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mouse 		lowest published lethal concentration: 3 gm/m3/2 hour Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration 		GISAAA 20(4),28,1955
inhalation
rat 		lethal concentration (50 percent kill): 4,000 ppm/4 hour N/R AEHLAU 1,343,1960
inhalation
rabbit 		lowest published lethal concentration: 20 gm/m3 Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration 		12OVAW -,176,1960
intraperitoneal
mouse 		lethal dose (50 percent kill): 585 mg/kg N/R YKKZAJ 97,1117,1977
intraperitoneal
rat 		lowest published lethal dose: 50 mg/kg N/R FATOAO 31,238,1968
oral
mouse 		lethal dose (50 percent kill): 500 mg/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity) 		BBIADT 44,795,1985
oral
rat 		lethal dose (50 percent kill): 540 mg/kg N/R AEHLAU 1,343,1960
skin
rabbit 		lethal dose (50 percent kill): 820 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 250 ppm/6 hour/24 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 6,559,1986
inhalation
rat 		lowest published toxic concentration: 4 mg/m3/24 hour/93 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(1),28,1968
oral
rat 		lowest published toxic dose: 4,994 mg/kg/11 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GISAAA 30(9),28,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 15 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (75 mg/m3) DTLVS* 3,84,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (75 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm, JAN1993
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (30 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 30 mg/m3, short term exposure limit 60 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 15 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 10 ppm, short term exposure limit 30 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 10 ppm (30 mg/m3), KTV 15 ppm (45 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (30 mg/m3), KZG- week 20 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (75 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (30 mg/m3), short term exposure limit 25 ppm (76 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 15 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 15 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLAMINE-air 10 hour time-weighted average 10 ppm;
short term exposure limit 25 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24680;
Number of Industries 20;
Total Number of Facilities 2,138;
Number of Occupations 28;
Total Number of Employees Exposed 34,647
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24680;
Number of Industries 22;
Total Number of Facilities 1,387;
Number of Occupations 24;
Total Number of Employees Exposed 28,361;
Total Number of Female Employees Exposed 6,878


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
NTP Carcinogenesis studies; selected, October 2000
OSHA ANALYTICAL METHOD #41


REFERENCES:

CODEN
REFERENCE
12OVAW "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJMBA2 Egyptian Journal of Microbiology. (National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.7- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS