The Registry of Toxic Effects of Chemical Substances

Diethylene glycol, dinitrate

RTECS #: ID6825000

CAS #: 693-21-0

UPDATE: June 2000 MW: 196.14 MF: C4H8N2O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Bis (hydroxyaethyl) - aether - dinitrat (German)
  2. Diglycoldinitraat (Dutch)
  3. Diglycol (dinitrate de) (French)
  4. Diglykoldinitrat (German)
  5. Ethanol, 2,2' - oxybisdinitrate
  1. Diethylenglykoldinitrate (Czech)
  2. Di (hydroxyethyl) ether dinitrate
  3. Dinitrate de diethylene - glycol (French)
  4. Dinitrodiglicol (Italian)
  5. Dinitrodiglykol (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R STGNBT -,91,1999
oral
guinea pig 		lethal dose (50 percent kill): 650 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Behavioral: Convulsions or effect on seizure threshold 		STGNBT -,91,1999
oral
mouse 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Cyanosis 		JHEMA2 17,114,1973
oral
rat 		lethal dose (50 percent kill): 753 mg/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Behavioral: Irritability 		ATDAEI 12,602,1993
oral
rabbit 		lethal dose (50 percent kill): 1,060 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Cardiac: Other changes

Behavioral: Convulsions or effect on seizure threshold 		STGNBT -,91,1999
skin
rabbit 		lethal dose : >2 gm/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Behavioral: Irritability 		ATDAEI 12,600,1993
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 39(11),13,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 860 µg/m3/17 week- intermittent Cardiac: EKG changes not diagnostic of above

Blood: Normocytic anemia

Blood: Luekopenia 		STGNBT -,91,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agent in glue, paint and resin production
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999

Used as an agent in glue, paint and resin production

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