The Registry of Toxic Effects of Chemical Substances

Diisopropylamine

RTECS #: IM4025000

CAS #: 108-18-9

UPDATE: November 2004 MW: 101.22 MF: C6H15N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Diisopropylamine (ACGIH:OSHA)
  2. N - (1 - Methylethyl) - 2 - propanamine
  1. 2 - Propanamine, N - (1 - methylethyl) - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 µg/plate (+/-enzymatic activation step) NUCADQ 3,129,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 2,207 ppm/72 minute Behavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands 		JIHTAB 31,142,1949
inhalation
guinea pig 		lowest published lethal concentration: 2,207 ppm/82 minute Behavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands 		JIHTAB 31,142,1949
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 4,200 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mouse 		lethal concentration (50 percent kill): 4,200 mg/m3/2 hour N/R 85GMAT -,54,1982
inhalation
rat 		lethal concentration (50 percent kill): 4,800 mg/m3/2 hour N/R 85GMAT -,54,1982
inhalation
rabbit 		lowest published lethal concentration: 2,207 ppm/2.5 hour Behavioral: Coma

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands 		JIHTAB 31,142,1949
oral
guinea pig 		lethal dose (50 percent kill): 2,800 mg/kg N/R GISAAA 45(3),79,1980
oral
mouse 		lethal dose (50 percent kill): 2,120 mg/kg N/R GISAAA 45(3),79,1980
oral
rat 		lethal dose (50 percent kill): 770 mg/kg N/R UCDS** 12/15/1971
oral
rabbit 		lethal dose (50 percent kill): 4,700 mg/kg N/R GISAAA 45(3),79,1980
subcutaneous
guinea pig 		lowest published lethal dose: 1,400 mg/kg N/R JIHTAB 31,142,1949
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R UCDS** 12,15,1971
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 600 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 597 ppm/7 hour/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 31,142,1949
inhalation
mouse 		lowest published toxic concentration: 48,300 ppb/6 hour/14 day- intermittent Olfaction: Other olfaction effects JJATDK 15,207,1995
inhalation
rabbit 		lowest published toxic concentration: 261 ppm/7 hour/54 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 31,142,1949
inhalation
rabbit 		lowest published toxic concentration: 597 ppm/7 hour/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 31,142,1949


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (20 mg/m3) (skin) DTLVS* 3,87,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (20 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (21 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOPROPYLAMINE-air 10 hour time-weighted average 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25850;
Number of Industries 91;
Total Number of Facilities 6,803;
Number of Occupations 99;
Total Number of Employees Exposed 91,123
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25850;
Number of Industries 3;
Total Number of Facilities 30;
Number of Occupations 7;
Total Number of Employees Exposed 4,577;
Total Number of Female Employees Exposed 745


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the preparation of vapor-phase inhibitors and rubber accelerators
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the preparation of vapor-phase inhibitors and rubber accelerators

RTECS Compound Description:
   Mutagen

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