The Registry of Toxic Effects of Chemical Substances

1,4:5,8 - Dimethanonaphthalene, 1,2,3,4,10,10 - hexachloro - 6,7 - epoxy - 1,4,4a,5,6,7,8,8a - octahydro - , endo,endo -

RTECS #: IO1575000

CAS #: 72-20-8

UPDATE: May 2005 MW: 380.90 MF: C12H8Cl6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Compound 269
  2. EN 57
  3. ENT 17,251
  4. Endrex
  5. Endricol
  6. Endrin
  7. Endrin (ACGIH:OSHA)
  8. Endrine (French)
  9. Experimental insecticide 269
  10. Hexachloroepoxyoctahydro - endo,endo - dimethanonaphthalene
  1. Hexadrin
  2. Latka 269 (Czech)
  3. Mendrin
  4. NCI - C00157
  5. OMS 197
  6. Oktanex
  7. RCRA waste number P051
  8. SD 3419
  9. Stardrin
  10. Stardrin 20


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
rat 		1 mg/kg BECTA6 9,65,1973
sister chromatid exchange multiple
other fish 		54 pmol/L MUREAV 118,61,1983
sperm morphology parenteral
rat 		10 mg/kg/10 day- continuous APTOA6 31,1,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 10 mg/kg (10 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) APTOA6 31,1,1972
oral
hamster 		lowest published toxic dose: 15 mg/kg (5-14 day pregnant) Reproductive: Effects on newborn: Behavioral TXCYAC 21,187,1981
oral
hamster 		lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		TJADAB 9,11,1974
oral
hamster 		lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 9,11,1974
oral
hamster 		lowest published toxic dose: 7,500 µg/kg (5-14 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TXAPA9 48,A200,1979
oral
hamster 		lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 48,A201,1979
oral
mouse 		lowest published toxic dose: 10 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JTEHD6 10,541,1982
oral
mouse 		lowest published toxic dose: 2,500 µg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 9,11,1974
oral
mouse 		lowest published toxic dose: 2,320 µg/kg (4 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		OYYAA2 6,673,1972
oral
mouse 		lowest published toxic dose: 7 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TCMUD8 5,3,1985
oral
mouse 		lowest published toxic dose: 16,500 µg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXCYAC 21,141,1981
oral
rat 		lowest published toxic dose: 2,320 µg/kg (4 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		OYYAA2 6,673,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 400 µg/kg Behavioral: Convulsions or effect on seizure threshold TOLED5 60,289,1992
intraperitoneal
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R TOLED5 60,289,1992
intravenous
mouse 		lethal dose (50 percent kill): 2,300 µg/kg N/R TXAPA9 23,408,1972
intravenous
pigeon 		lethal dose (50 percent kill): 1,500 µg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 9,75,1966
oral
wild bird 		lethal dose (50 percent kill): 1,780 µg/kg N/R ASTTA8 (680),157,1979
oral
cat 		lowest published lethal dose: 5 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		JAFCAU 3,842,1955
oral
chicken 		lowest published lethal dose: 2 mg/kg Behavioral: Ataxia

Behavioral: Irritability 		CNVJA9 11,74,1970
oral
duck 		lethal dose (50 percent kill): 5,330 µg/kg N/R TXAPA9 22,556,1972
oral
guinea pig 		lethal dose (50 percent kill): 16 mg/kg N/R PCOC** -,475,1966
oral
hamster 		lethal dose (50 percent kill): 10 mg/kg N/R TJADAB 9,11,1974
oral
man 		lowest published lethal dose: 171 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Thrombocytopenia 		HUTODJ 4,241,1985
oral
monkey 		lethal dose (50 percent kill): 3 mg/kg N/R PCOC** -,475,1966
oral
mouse 		lethal dose (50 percent kill): 1,370 µg/kg N/R TXAPA9 25,42,1973
oral
mouse 		lowest published toxic dose: 137 µg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 175,73,2002
oral
pigeon 		lethal dose (50 percent kill): 5,600 µg/kg N/R TXAPA9 21,315,1972
oral
quail 		lethal dose (50 percent kill): 4,210 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 3 mg/kg N/R WRPCA2 9,119,1970
oral
rabbit 		lethal dose (50 percent kill): 7 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		JAFCAU 3,842,1955
oral
woman 		lowest published lethal dose: 234 mg/kg Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase 		NEZAAQ 22,254,1967
skin
cat 		lowest published lethal dose: 75 mg/kg Behavioral: Food intake (animal)

Behavioral: Withdrawal

Gastrointestinal: Nausea or vomiting 		CVETAA 2,71,1958
skin
rat 		lethal dose (50 percent kill): 12 mg/kg N/R SPEADM 78-1,13,1978
skin
rabbit 		lethal dose (50 percent kill): 60 mg/kg N/R SPEADM 78-1,13,1978
unreported route
rat 		lethal dose (50 percent kill): 17 mg/kg N/R 30ZDA9 -,64,1971
unreported route
rabbit 		lethal dose (50 percent kill): 7 mg/kg N/R 30ZDA9 -,64,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 360 ppb/7 hour/22 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955
inhalation
rabbit 		lowest published toxic concentration: 360 ppb/7 hour/24 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955
oral
dog 		lowest published toxic dose: 12,150 µg/kg/81 week- intermittent Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		JAFCAU 3,842,1955
oral
rat 		lowest published toxic dose: 1,975 mg/kg/79 day- intermittent Eye: Hemorrhage

Behavioral: Excitement

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 14,556,1969
oral
rat 		lowest published toxic dose: 219 mg/kg/2 year- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes 		JAFCAU 3,842,1955
oral
rat 		lowest published toxic dose: 6,720 mg/kg/16 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAFCAU 4,696,1956
oral
rabbit 		lowest published toxic dose: 50 mg/kg/72 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955
skin
rabbit 		lowest published toxic dose: 1,400 mg/kg/14 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAFCAU 3,842,1955


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 5,157,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 5,157,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
BECTA6 15,283,1976
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
26UZAB 6,149,1968/1970
TOXICOLOGY REVIEW
MUREAV 567,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,180,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,98,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDRIN-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as an insecticide, avicide, and rodenticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Endrin, 5519
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-12,1979


REFERENCES:

CODEN
REFERENCE
26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CNVJA9 Canadian Veterinary Journal. (339 Booth St., Ottawa, ON K1R 6J3, Canada) V.1- 1960-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide, avicide, and rodenticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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