The Registry of Toxic Effects of Chemical Substances

Disulfide, bis (dimethylthiocarbamoyl)

RTECS #: JO1400000

CAS #: 137-26-8

UPDATE: November 2004 MW: 240.44 MF: C6H12N2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aceto TETD
  2. Arasan
  3. Arasan 70
  4. Arasan 75
  5. Arasan - M
  6. Arasan 42 - S
  7. Arasan - SF
  8. Arasan - SF - X
  9. Aules
  10. Chipco thiram 75
  11. Thiuram M
  12. Thiuram M rubber accelerator
  13. Thiuramyl
  14. Thylate
  15. Tigam
  16. Tirampa
  17. Tiuram (Polish)
  18. Tiuramyl
  19. TMTDS
  20. TMTD
  21. Accelerator thiuram
  22. Tridipam
  23. Tripomol
  24. TUEX
  25. Tulisan
  26. Tuads
  27. USAF P - 5
  28. USAF B - 30
  29. USAF EK - 2089
  30. Vancida TM - 95
  31. Vancide TM
  32. Bis ( (dimethylamino) carbonothioyl) disulphide
  33. VUAgT - I - 4
  34. Vulcafor TMTD
  35. Vulkacit MTIC
  36. Vulkacit thiuram
  37. Vulkacit thiuram/C
  38. ZUPA S 80
  39. Bis (dimethyl - thiocarbamoyl) - disulfid (German)
  40. Bis (dimethylthiocarbamoyl) disulfide
  41. Bis (dimethylthiocarbamoyl) disulphide
  42. Bis (dimethylthiocarbamyl) disulfide
  43. Cyuram DS
  44. Disolfuro di tetrametiltiourame (Italian)
  45. Disulfure de tetramethylthiourame (French)
  46. alpha,alpha' - Dithiobis (dimethylthio) formamide
  47. N,N' - (Dithiodicarbonothioyl) bis (N - methylmethanamine)
  48. Ekagom TB
  49. FMC 2070
  50. Formamide, 1,1' - dithiobis (N,N - dimethylthio -
  51. Hermal
  52. Hermat TMT
  53. Heryl
  54. Hexathir
  55. Kregasan
  56. Mercuram
  57. Methyl thiram
  58. Methyl thiuramdisulfide
  59. Methyl tuads
  60. Micropearls
  61. Puralin
  62. Radothiram
  63. RCRA waste number U244
  1. Spotrete
  2. Spotrete - F
  3. SQ 1489
  4. Trametan
  5. Falitiram
  6. Fermide
  7. Fernacol
  8. Fernasan
  9. Fernasan A
  10. Fernide
  11. Flo Pro T Seed Protectant
  12. Nobecutan
  13. Nomersan
  14. Normersan
  15. Panoram 75
  16. Polyram ultra
  17. Pomarsol
  18. Pomarsol forte
  19. Pomasol
  20. Rezifilm
  21. Royal TMTD
  22. Sadoplon
  23. Tersan
  24. Tersan 75
  25. Tetramethyldiurane sulphite
  26. Tetramethylenethiuram disulphide
  27. Tetramethylthiocarbamoyldisulphide
  28. Tetramethylthioperoxydicarbonic diamide
  29. Tetramethylthioramdisulfide (Dutch)
  30. Tetramethyl - thiram disulfid (German)
  31. Tetramethylthiuram bisulfide
  32. Tetramethylthiuram bisulphide
  33. Tetramethylthiuram disulfide
  34. N,N,N',N' - Tetramethylthiuram disulfide
  35. Tetramethylthiuram disulphide
  36. N,N - Tetramethylthiuram disulphide
  37. Tetramethylthiuran disulphide
  38. Tetramethyl thiurane disulfide
  39. Tetramethyl thiurane disulphide
  40. Tetramethylthiurum disulfide
  41. Tetramethylthiurum disulphide
  42. Tetrapom
  43. Tetrathiuram disulfide
  44. Tetrathiuram disulphide
  45. Thillate
  46. Thimer
  47. Thioknock
  48. Thiotox (fungicide)
  49. Thiosan
  50. Thiram
  51. Thiram (ACGIH:OSHA)
  52. Thiram 75
  53. Thiramad
  54. Thiram B
  55. Thirame (French)
  56. Thirasan
  57. Thiulix
  58. Thiurad
  59. Thiuram
  60. Thiuram D
  61. Thiuram disulfide, tetramethyl -
  62. Thiuramin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 28ZPAK -,278,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		80 mg/kg/3 day- continuous FCTOD7 25,709,1987
dominant lethal test oral
mouse 		150 mg/kg/8 week- continuous FCTOD7 35,523,1997
DNA damage human lymphocyte 100 µg/L FCTOD7 36,155,1998
DNA damage oral
mouse 		2,400 mg/kg/8 day- continuous FCTOD7 36,155,1998
DNA inhibition human lymphocyte 1 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 100 µg/L ARTODN 45,101,1980
DNA repair Bacillus subtilis 2 µg/disc MUREAV 40,19,1976
DNA repair Salmonella typhimurium 50 µg/plate MUREAV 89,1,1981
mutation in microorganisms Aspergillus nidulans 500 ng/plate (-enzymatic activation step) MUREAV 89,1,1981
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+enzymatic activation step) MUREAV 68,9,1979
mutation in microorganisms Salmonella typhimurium 5 µg/plate (-enzymatic activation step) MUREAV 68,313,1979
micronucleus test human lymphocyte 5 mg/L FCTOD7 36,155,1998
micronucleus test intraperitoneal
mouse 		100 mg/kg FCTOD7 23,373,1985
mutation in mammalian somatic cells hamster lung 5 mg/L FCTOD7 23,373,1985
morphological transform oral
rat 		2,520 mg/kg/6 week CRNGDP 9,387,1988
phage inhibition capacity Escherichia coli 1 µg/tube MUREAV 89,1,1981
sex chromosome loss and nondisjunction Aspergillus nidulans 20 ppm MUREAV 89,297,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		4 gm/L SWEHDO 9(Suppl 2),27,1983
sperm morphology intraperitoneal
mouse 		100 mg/kg PMRSDJ 2,79,1981
sperm morphology oral
mouse 		80 mg/kg/3 day- continuous FCTOD7 25,709,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 125 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 15,152,1969
oral
hamster 		lowest published toxic dose: 250 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 15,152,1969
oral
hamster 		lowest published toxic dose: 250 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Body wall TXAPA9 15,152,1969
oral
hamster 		lowest published toxic dose: 300 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 15,152,1969
oral
mammal (species unspecified) 		lowest published toxic dose: 848 mg/kg (60 day prior to copulation/1-53 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 4,20,1984
oral
mouse 		lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ATXKA8 30,251,1973
oral
mouse 		lowest published toxic dose: 300 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ATXKA8 30,251,1973
oral
mouse 		lowest published toxic dose: 80 mg/kg (3 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FCTOD7 25,709,1987
oral
rat 		lowest published toxic dose: 1,200 mg/kg (7-12 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		TXAPA9 35,83,1976
oral
rat 		lowest published toxic dose: 300 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		GISAAA 43(6),37,1978
oral
rat 		lowest published toxic dose: 1,190 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 35,83,1976
oral
rat 		lowest published toxic dose: 550 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral AEEDDS 2,215,1976
oral
rat 		lowest published toxic dose: 420 mg/kg (1-20 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Biochemical and metabolic 		GISAAA 51(6),23,1986
oral
rat 		lowest published toxic dose: 1,800 mg/kg (1 year male) Reproductive: Paternal effects: Testes, epididymis, sperm duct IJEBA6 36,390,1998
parenteral
rat 		lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BEXBAN 93,107,1982
parenteral
rat 		lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BEXBAN 93,107,1982
subcutaneous
mouse 		lowest published toxic dose: 90 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		NTIS** PB223-160
subcutaneous
mouse 		lowest published toxic dose: 1,035 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB223-160
unreported route
rat 		lowest published toxic dose: 50 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		HBPTO* 1,738,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 108 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		RPZHAW 31,67,1980
subcutaneous
mouse 		lowest published toxic dose: 46 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159
skin
mouse 		lowest published toxic dose: 100 mg/kg Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Skin and Appendages: Tumors 		FCTOD7 34,283,1996
skin
mouse 		toxic dose : 15,300 mg/kg/51 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		FCTOD7 34,283,1996


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 30 µg/m3/5 year- intermittent Eye: Conjunctiva irritation

Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		VRDEA5 (10),136,1971
inhalation
rat 		lethal concentration (50 percent kill): 500 mg/m3/4 hour N/R 85JCAE -,1027,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 70 mg/kg N/R NIIRDN 6,566,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 138 mg/kg Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease 		JNPHAG 9,35,1978
oral
wild bird 		lethal dose (50 percent kill): 300 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lowest published lethal dose: 230 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Analgesia 		JPETAB 17,349,1921
oral
mouse 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		GTPZAB 6(7),28,1962
oral
rat 		lethal dose (50 percent kill): 560 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 11,546,1967
oral
rabbit 		lethal dose (50 percent kill): 210 mg/kg N/R KOKABN 26,358,1977
subcutaneous
mouse 		lethal dose (50 percent kill): 1,109 mg/kg N/R NNGADV 15,507,1990
subcutaneous
rat 		lethal dose (50 percent kill): 646 mg/kg N/R NNGADV 15,507,1990
skin
rat 		lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity) ATDAEI 15(Suppl 1),S76,1996
skin
rabbit 		lowest published lethal dose: 1 gm/kg N/R 85GMAT -,110,1982
unreported route
chicken 		lethal dose (50 percent kill): 840 mg/kg N/R VETNAL 54(2),70,1978
unreported route
domestic animal 		lethal dose (50 percent kill): 225 mg/kg N/R VETNAL 54(2),70,1978
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 400 mg/kg N/R GISAAA 45(5),29,1980
unreported route
mouse 		lethal dose (50 percent kill): 1,150 mg/kg N/R KOKABN 26,358,1977
unreported route
rat 		lethal dose (50 percent kill): 740 mg/kg N/R KOKABN 26,358,1977
unreported route
rat 		lowest published toxic dose: 50 mg/kg Endocrine: Evidence of thyroid hypofunction HBPTO* 1,738,2001
unreported route
rabbit 		lethal dose (50 percent kill): 210 mg/kg N/R VETNAL 54(2),70,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 91 mg/m3/26 week- intermittent Cardiac: Other changes TPKVAL 15,3,1979
oral
dog 		lowest published toxic dose: 29,120 mg/kg/2 year- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTSCDR 5,269,1980
oral
dog 		lowest published toxic dose: 1,120 mg/kg/4 week- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 15,507,1990
oral
mouse 		lowest published toxic dose: 1,560 µg/kg/3 day- intermittent Vascular: Other changes BJCAAI 86,779,2002
oral
mouse 		lowest published toxic dose: 12,000 µg/kg/4 week- intermittent Vascular: Other changes

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		BJCAAI 86,779,2002
oral
mouse 		lowest published toxic dose: 4,680 µg/kg/3 week- intermittent Liver: Other changes

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		BJCAAI 86,779,2002
oral
pig 		lowest published toxic dose: 1,820 µg/kg/1 year- continuous Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Other changes 		CUTOEX 1,221,1993
oral
rat 		lowest published toxic dose: 450 mg/kg/90 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		INHEAO 31,59,1993
oral
rat 		lowest published toxic dose: 406 mg/kg/14 day- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		BCTKAG 17,69,1984
oral
rat 		lowest published toxic dose: 350 mg/kg/7 day- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals 		ARTODN 48,29,1981
oral
rat 		lowest published toxic dose: 10,920 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTSCDR 5,269,1980
oral
rat 		lowest published toxic dose: 1,680 mg/kg/4 week- continuous Blood: Changes in erythrocyte (RBC) count

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 15,507,1990
oral
rabbit 		lowest published toxic dose: 1,520 mg/kg/15 week- intermittent Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 6(7),28,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,225,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,225,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,403,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,403,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,403,1991
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,154,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,257,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, short term exposure limit 25 mg/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Sb)/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIRAM-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71900;
Number of Industries 14;
Total Number of Facilities 1,502;
Number of Occupations 37;
Total Number of Employees Exposed 17,330
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71900;
Number of Industries 23;
Total Number of Facilities 2,234;
Number of Occupations 48;
Total Number of Employees Exposed 47,798;
Total Number of Female Employees Exposed 9,520


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as volcanizing agent for rubber, a seed disinfectant, a lubricating oil additive
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Thiram, 5005


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEEDDS Adverse Effects of Environmental Chemicals and Psychotropic Drugs. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1973-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
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Used as volcanizing agent for rubber, a seed disinfectant, a lubricating oil additive

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 12680-07-8
ALT CAS #: 12680-62-5
ALT CAS #: 39456-80-9
ALT CAS #: 66173-72-6
ALT CAS #: 93196-73-7
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