RTECS:KH7650000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

Ethane, 1 - chloro - 1,1 - difluoro -

RTECS #: KH7650000

CAS #: 75-68-3

UPDATE: November 2004 MW: 100.50 MF: C₂H₃ClF₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

CFC 142b

1 - Chloro - 1,1 - difluoroethane

Chloroethylidene fluoride

alpha - Chloroethylidene fluoride

1,1 - Difluoro - 1 - chloroethane

Freon 142

Freon 142b

Genetron 101

Genetron 142b

Gentron 142B

Hydrochlorofluorocarbon 142b

Isotron 142b

Monochlorodifluoroethane

FC142b

Fluorocarbon FC142b

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 50 pph/24 hour (-enzymatic activation step) TXAPA9 72,15,1984

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 1,000 ppm/6 hour (3-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NTIS OTS0555347

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
inhalation
mouse lethal concentration (50 percent kill): 1,758,000 mg/m³/2 hour N/R VCVGH* -,633,1990
inhalation
rat lowest published lethal concentration: 212,000 mg/m³/30 minute N/R VCVGH* -,633,1990
inhalation
rat lethal concentration (50 percent kill): 2,050,000 mg/m³/4 hour N/R VCVGH* -,633,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 500 gm/m³/4 hour/4 week- intermittent Endocrine: Evidence of thyroid hypofunction TPKVAL 9,175,1967
inhalation
rat lowest published toxic concentration: 10 pph/16 hour/9 day- intermittent Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHOAX 2(3),335,1950

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 1000 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m³, short term exposure limit 200 mg/m³, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 3000 mg/m³, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 8380 mg/m³, 2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82201;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the production of highly specialized fluoropolymers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AIHOAX Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an intermediate in the production of highly specialized fluoropolymers

RTECS Compound Description:
Mutagen
Reproductive Effector

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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 1,000 ppm/6 hour (3-15 day pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	NTIS** OTS0555347

SYNONYMS:
CFC 142b 1 - Chloro - 1,1 - difluoroethane Chloroethylidene fluoride alpha - Chloroethylidene fluoride 1,1 - Difluoro - 1 - chloroethane Freon 142 Freon 142b Genetron 101	Genetron 142b Gentron 142B Hydrochlorofluorocarbon 142b Isotron 142b Monochlorodifluoroethane FC142b Fluorocarbon FC142b

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
mutation in microorganisms	Salmonella typhimurium	50 pph/24 hour (-enzymatic activation step)	TXAPA9 72,15,1984

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lethal concentration (50 percent kill): 1,758,000 mg/m³/2 hour	N/R	VCVGH* -,633,1990
inhalation rat	lowest published lethal concentration: 212,000 mg/m³/30 minute	N/R	VCVGH* -,633,1990
inhalation rat	lethal concentration (50 percent kill): 2,050,000 mg/m³/4 hour	N/R	VCVGH* -,633,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 500 gm/m³/4 hour/4 week- intermittent	Endocrine: Evidence of thyroid hypofunction	TPKVAL 9,175,1967
inhalation rat	lowest published toxic concentration: 10 pph/16 hour/9 day- intermittent	Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AIHOAX 2(3),335,1950

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - AUSTRIA	MAK 1000 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY	MAK 1000 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - HUNGARY	time-weighted average 100 mg/m³, short term exposure limit 200 mg/m³, JAN1993
Occupational Exposure Limit - RUSSIA	short term exposure limit 3000 mg/m³, JAN1993
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 8380 mg/m³, 2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 82201; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the production of highly specialized fluoropolymers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AIHOAX	Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH*	"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.