The Registry of Toxic Effects of Chemical Substances

Ethane, 2 - chloro - 1,1,1 - trifluoro -

RTECS #: KH8008500

CAS #: 75-88-7

UPDATE: September 1999 MW: 118.49 MF: C2H2ClF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. CFC 133a
  2. 1 - Chloro - 2,2,2 - trifluoroethane
  3. 2 - Chloro - 1,1,1 - trifluoroethane
  4. Freon 133a
  5. Genetron 133a
  1. R 133a
  2. FC 133a
  3. 1,1,1 - Trifluoro - 2 - chloroethane
  4. 2,2,2 - Trifluorochloroethane
  5. 1,1,1 - Trifluoroethyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 78 gm/kg/1 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors

Reproductive: Tumorigenic effects: Uterine tumors 		TXAPA9 72,15,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 33,000 ppm/5 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema 		NTIS** OTS0530594
inhalation
mouse 		lethal concentration (50 percent kill): 15 pph/1 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold 		BJANAD 37,716,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 10 pph/1 hour/25 day- intermittent Behavioral: General anesthetic

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Interstitial nephritis 		NTIS** OTS0528422


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 41,253,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1355,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,253,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1355,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1355,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate in production of HALOTHANE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a chemical intermediate in production of HALOTHANE

RTECS Compound Description:
   Tumorigen

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