The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1 - dichloro - 1 - nitro -

RTECS #: KI1050000

CAS #: 594-72-9

UPDATE: November 2004 MW: 143.96 MF: C2H3Cl2NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dichloor - 1 - nitroethaan (Dutch)
  2. 1,1 - Dichlor - 1 - nitroaethan (German)
  3. 1,1 - Dichloro - 1 - nitroethane
  4. 1,1 - Dichloro - 1 - nitroethane (ACGIH:OSHA)
  1. 1,1 - Dicloro - 1 - nitroetano (Italian)
  2. Dichloronitroethane
  3. Ethide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 333 µg/plate (-enzymatic activation step) EMMUEG 19(Suppl 21),2,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 580 mg/m3/6 hour Eye: Lacrimation

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Cough 		JIHTAB 27,95,1945
inhalation
rabbit 		lowest published lethal concentration: 580 mg/m3/6 hour Eye: Lacrimation

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Cough 		JIHTAB 27,95,1945
intraperitoneal
mouse 		lethal dose (50 percent kill): 240 mg/kg N/R KHFZAN 10(6),53,1976
oral
rat 		lethal dose (50 percent kill): 410 mg/kg N/R BESAAT 12,161,1966
oral
rabbit 		lowest published lethal dose: 150 mg/kg Vascular: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Ulceration or bleeding from stomach 		JIHTAB 27,95,1945


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 10 ppm (60 mg/m3) DTLVS* 3,82,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 10 ppm (60 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 10 ppm (60 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 10 ppm (60 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 10 ppm (60 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (12 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 99m (12 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (60 mg/m3), short term exposure limit 20 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 30 mg/m3, MAC(short term exposure limit) 60 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1-DICHLORO-1-NITROETHANE-air 10 hour time-weighted average 2 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1-Dichloro-1-nitroethane, 1601


REFERENCES:

CODEN
REFERENCE
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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