The Registry of Toxic Effects of Chemical Substances

Ethane, 1,2 - difluoro - 1,1,2,2 - tetrachloro -

RTECS #: KI1420000

CAS #: 76-12-0

UPDATE: November 2004 MW: 203.82 MF: C2Cl4F2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1,2,2 - Tetrachloro - 1,2 - difluoroethane
  2. 1,1,2,2 - Tetrachloro - 1,2 - difluoroethane (ACGIH:OSHA)
  3. 1,2 - Difluoro - 1,1,2,2 - tetrachloroethane
  4. CFC - 112
  5. Daiflon 112
  6. Daiflon S2
  7. Ethane, 1,1,2,2 - tetrachloro - 1,2 - difluoro -
  1. F - 112
  2. Freon 112
  3. Genetron 112
  4. Halocarbon 112
  5. R 112
  6. Refrigerant 112
  7. Ucon 112


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
guinea pig 		100 mg/20S rinse mild AIHAAP 27,332,1966
skin
guinea pig 		1,00%/24 hour open irritation test mild AIHAAP 27,332,1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 50 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		TLSMA6 75,241,1963
inhalation
mouse 		lowest published lethal concentration: 40,000 mg/m3/2 hour N/R VCVGH* -,634,1990
inhalation
mouse 		lethal concentration (50 percent kill): 123,000 mg/m3/2 hour N/R VCVGH* -,634,1990
inhalation
rat 		lethal concentration (50 percent kill): 2 pph/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		HUTODJ 1,239,1982
inhalation
rat 		lowest published toxic concentration: 84,000 mg/m3 Behavioral: General anesthetic VCVGH* -,634,1990
inhalation
rat 		lethal concentration (50 percent kill): 125,000 mg/m3/4 hour N/R VCVGH* -,634,1990
inhalation
rat 		lowest published lethal concentration: 258,000 mg/m3/40 minute N/R VCVGH* -,634,1990
oral
guinea pig 		lowest published lethal dose: >10 gm/kg N/R NTIS** OTS0520705
oral
mouse 		lethal dose (50 percent kill): 800 mg/kg N/R 85GMAT -,54,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/31 day- intermittent Liver: Other changes

Blood: Luekopenia 		AIHAAP 27,332,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (4170 mg/m3) DTLVS* 3,249,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 500 ppm (4170 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (1690 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 500 ppm (4170 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (1665 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (4170 mg/m3), short term exposure limit 625 ppm (5215 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 500 ppm (4170 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (1690 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 850 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (4170 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (4200 mg/m3), short term exposure limit 1000 ppm, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 PPM (847 MG/ minute3), short term exposure limit 100 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 500 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE-air time-weighted average 500 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71447;
Number of Industries 8;
Total Number of Facilities 451;
Number of Occupations 7;
Total Number of Employees Exposed 7,803
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71447;
Number of Industries 5;
Total Number of Facilities 95;
Number of Occupations 5;
Total Number of Employees Exposed 1,434;
Total Number of Female Employees Exposed 191


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, a solvent extractant, and in dry cleaning industry
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016
NTP Toxicity studies, RPT# TOX-45, October 2000


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a refrigerant, a solvent extractant, and in dry cleaning industry

RTECS Compound Description:
   Tumorigen
   Primary Irritant

 Click Here for Additional Information about RTECS