RTECS:KI5600000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Ethane, nitro -

RTECS #: KI5600000

CAS #: 79-24-3

UPDATE: November 2004 MW: 75.08 MF: C₂H₅NO₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Nitroetan (Polish)

Nitroethane

Nitroethane (ACGIH:OSHA)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
guinea pig lowest published lethal concentration: 10,000 ppm/3 hour N/R JIHTAB 22,315,1940
inhalation
mouse lowest published lethal concentration: 19,500 mg/m³/2 hour N/R 85GMAT -,93,1982
inhalation
rat lowest published lethal concentration: 13,000 ppm/6 hour N/R 85INA8 6,1105,1991
inhalation
rabbit lowest published lethal concentration: 5,000 ppm/2 hour N/R JIHTAB 22,315,1940
intraperitoneal
mouse lethal dose (50 percent kill): 310 mg/kg N/R KHFZAN 10(6),53,1976
intraperitoneal
rat lowest published lethal dose: 1,600 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia BSPLA9 (4),137,1972
oral
child lowest published toxic dose: 1,478 無/kg Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia JTCTDW 32,321,1994
oral
mouse lethal dose (50 percent kill): 860 mg/kg Behavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement GISAAA 32(9),9,1967
oral
rat lethal dose (50 percent kill): 1,100 mg/kg Behavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement GISAAA 32(9),9,1967
oral
rabbit lowest published lethal dose: 500 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation JIHTAB 22,315,1940

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published toxic concentration: 2,000 ppm/6 hour/4 day- intermittent Behavioral: Hallucinations, distorted perceptions

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS OTS0539250
inhalation
mouse lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Liver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia NTIS OTS0539250
inhalation
rat lowest published toxic concentration: 2,000 ppm/6 hour/4 day- intermittent Behavioral: Hallucinations, distorted perceptions

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS OTS0539250
inhalation
rat lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS OTS0539250

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (310 mg/m³) DTLVS* 3,185,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (310 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (310 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (310 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (310 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (310 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (310 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (307 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (310 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (310 mg/m³), short term exposure limit 150 ppm (465 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (310 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (310 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 60 mg/m³, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (310 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 30 mg/m³, MAC(short term exposure limit) 240 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 30 mg/m³, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 20 ppm (60 mg/m³), short term exposure limit 50 ppm (150 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (310 mg/m³), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (310 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (312 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROETHANE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50795;
Number of Industries 8;
Total Number of Facilities 109;
Number of Occupations 10;
Total Number of Employees Exposed 6,001;
Total Number of Female Employees Exposed 1,652

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for polymers and as stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitroethane, 2526

REFERENCES:
CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
BSPLA9 Bulletin de la Societe de Pharmacie de Lille. (Societe de Pharmacie du Lille, 3, rue du Professeur Laguesse, 59045 Lille, Franch) V.1- 1945-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as solvent for polymers and as stabilizer

NIOSH PROFILE (NITROPARAFFINS), SRC, 11/81

RTECS Compound Description:
Mutagen
Human Data

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