The Registry of Toxic Effects of Chemical Substances

Ethane, pentachloro -

RTECS #: KI6300000

CAS #: 76-01-7

UPDATE: November 2004 MW: 202.28 MF: C2HCl5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Ethane pentachloride
  2. NCI - C53894
  3. Pentachloorethaan (Dutch)
  4. Pentachloraethan (German)
  5. Pentachlorethane (French)
  1. Pentachloroethane
  2. Pentacloroetano (Italian)
  3. Pentalin
  4. RCRA waste number U184


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 80 mg/L MUREAV 369,243,1996
mutation in microorganisms Saccharomyes cerevisiae 2,500 µmol/L (+enzymatic activation step) TCMUD8 9,349,1989
mutation in mammalian somatic cells mouse lymphocyte 70 mg/L EMMUEG 12,85,1988
other mutation test systems Escherichia coli 25,814 µmol/L EMMUEG 19,98,1992
other mutation test systems oral
mouse 		500 mg/kg MUREAV 343,157,1995
sister chromatid exchange hamster ovary 100 mg/L SCIEAS 236,933,1987
sex chromosome loss and nondisjunction human lung 80 mg/L MUREAV 369,243,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 71,750 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB83-206748
oral
rat 		lowest published toxic dose: 108,150 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NTIS** PB83-206748


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 17 mg/m3 Behavioral: General anesthetic VCVGH* -,390,1990
inhalation
mouse 		lowest published toxic concentration: 7,500 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,307,1990
inhalation
mouse 		lowest published lethal concentration: 35,000 mg/m3/2 hour N/R VCVGH* -,390,1990
inhalation
rat 		lethal concentration (50 percent kill): 4,238 ppm/2 hour N/R 85JCAE -,97,1986
intravenous
dog 		lowest published lethal dose: 100 mg/kg N/R QJPPAL 7,205,1934
oral
dog 		lowest published lethal dose: 500 mg/kg Behavioral: Sleep

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration 		AJHYA2 16,325,1932
oral
rat 		lethal dose (50 percent kill): 920 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Liver: Other changes 		SRTCAC 36(1-4),10,1989
subcutaneous
rabbit 		lowest published lethal dose: 700 mg/kg N/R QJPPAL 7,205,1934


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-232,1982
oral
mouse 		lowest published toxic dose: 14 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-232,1982
oral
rat 		lowest published toxic dose: 7 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-232,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 41,99,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 41,99,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1519,1999
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (40 mg/m3), short term exposure limit 10 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (40 mg/m3), KZG- week 10 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (40 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 40 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROETHANE-air Handle with caution NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6173;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 7;
Total Number of Employees Exposed 232;
Total Number of Female Employees Exposed 3


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of TETRACHLOROETHYLENE and as solvent for CELLULOSE ACETATE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Pentachloroethane, 2517
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NTP Toxicity studies, RPT# TOX-45, October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in manufacture of TETRACHLOROETHYLENE and as solvent for CELLULOSE ACETATE

NIOSH PROFILE (PENTACHLOROETHANE), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

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