The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1,2 - trichloro - 1,2,2 - trifluoro -

RTECS #: KJ4000000

CAS #: 76-13-1

UPDATE: November 2004 MW: 187.37 MF: C2Cl3F3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1,2 - Trichloro - 1,2,2 - trifluoroethane
  2. 1,1,2 - Trichloro - 1,2,2 - trifluoroethane (ACGIH:OSHA)
  3. 1,1,2 - Trichlorotrifluoroethane
  4. 1,1,2 - Trifluoro - 1,2,2 - trichloroethane
  5. 1,1,2 - Trifluorotrichloroethane
  6. 1,2,2 - Trichlorotrifluoroethane
  7. Arcton 63
  8. Arklone P
  9. Asahifron 113
  10. CFC - 113
  11. Chlorofluorethane
  12. Chlorofluorocarbon 113
  13. Daiflon S 3
  14. F 113
  15. FC 113
  16. Fluorocarbon 113
  17. Freon 113
  18. Freon 113, commercial grade
  19. Freon 113, contaminated
  20. Freon 113, specially purified
  1. Freon 113TR - T
  2. Freon F113
  3. Freon TF
  4. Freon - TF
  5. Frigen 113
  6. Frigen 113 TR - T
  7. Frigen 113TR
  8. Frigen 113TR - N
  9. Frigen 113a
  10. Genetron 113
  11. Halocarbon 113
  12. Isceon 113
  13. Kaiser chemicals 11
  14. Khladon 113
  15. Ledon 113
  16. R 113
  17. R 113 (Halocarbon)
  18. Racon 113
  19. Refrigerant 113
  20. Refrigerant R 113


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test mild UCDS** 7/10/1970
skin
rabbit 		500 mg/24 hour mild 85JCAE -,137,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rabbit 		lowest published toxic concentration: 20 ppm (8-16 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Physical 		EPASR* #86-890000920S
oral
rabbit 		lowest published toxic dose: 5 gm/kg (8 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** OTS0571230


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): >12 pph/2 hour N/R AMPMAR 29,381,1968
inhalation
guinea pig 		lowest published lethal concentration: 4 pph/60 minute Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage 		TJIDAH 95,1283,1980
inhalation
human 		lowest published toxic concentration: 2,500 ppm/90 minute Ear: Changes in vestibular functions

Behavioral: Change in psychophysiological tests 		EPASR* #86-890000889S
inhalation
human 		lowest published toxic concentration: 2,500 ppm/90 minute Behavioral: Change in psychophysiological tests AIHAAP 28,43,1967
inhalation
mouse 		lethal concentration (50 percent kill): 260 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		TLSMA6 75,241,1963
inhalation
mouse 		lowest published lethal concentration: 230,000 mg/m3/2 hour N/R VCVGH* -,636,1990
inhalation
mouse 		lethal concentration (50 percent kill): 467,000 mg/m3/2 hour N/R VCVGH* -,636,1990
inhalation
mouse 		lowest published toxic concentration: 393,000 mg/m3/1 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: General anesthetic 		VCVGH* -,636,1990
inhalation
rat 		lethal concentration (50 percent kill): 38,500 ppm/4 hour Behavioral: General anesthetic

Behavioral: Excitement

Behavioral: Ataxia 		NTIS** OTS0520341
inhalation
rat 		lethal concentration (50 percent kill): 53.3 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		EPASR* #86-890000903S
inhalation
rat 		lowest published lethal concentration: 57,500 ppm/4 hour Behavioral: Tremor

Behavioral: Excitement 		EPASR* #86-890000906S
inhalation
rat 		lowest published lethal concentration: 37 ppm/4 hour Behavioral: Tremor

Behavioral: Ataxia 		EPASR* #86-890000902S
inhalation
rat 		lethal concentration (50 percent kill): 38.5 ppm/4 hour N/R EPASR* #86-890000902S
inhalation
rat 		lowest published lethal concentration: 45 ppm/4 hour Behavioral: Tremor

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		EPASR* #86-890000895S
inhalation
rat 		lethal concentration (50 percent kill): 52.5 ppm/4 hour Behavioral: Tremor

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		EPASR* #86-890000895S
inhalation
rat 		lowest published lethal concentration: 48.5 ppm/4 hour Behavioral: Tremor

Behavioral: Excitement

Gastrointestinal: Changes in structure or function of salivary glands 		EPASR* #86-890000905S
inhalation
rat 		lowest published lethal concentration: 786,000 mg/m3/4 hour N/R VCVGH* -,636,1990
inhalation
rabbit 		lethal concentration (50 percent kill): 59,500 ppm/2 hour Eye: Other eye effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation 		NTIS** OTS0520343
inhalation
rabbit 		lowest published lethal concentration: 55.12 ppm/2 hour Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands 		EPASR* #86-890000904S
inhalation
rabbit 		lethal concentration (50 percent kill): 59.5 ppm/2 hour Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory obstruction 		EPASR* #86-890000904S
intraperitoneal
mouse 		lowest published toxic dose: 23,200 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		ENVRAL 45,101,1988
intravenous
mouse 		lethal dose (50 percent kill): 9 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Altered sleep time (including change in righting reflex)

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0520355
oral
guinea pig 		lowest published lethal dose: >10 gm/kg N/R NTIS** OTS0520705
oral
rat 		lethal dose (50 percent kill): 43 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair 		JMCMAR 7,378,1964
oral
rat 		lethal dose (50 percent kill): 43 gm/kg Behavioral: General anesthetic VCVGH* -,636,1990
oral
rabbit 		lowest published lethal dose: 17 gm/kg N/R AIHAAP 29,521,1968
skin
rabbit 		lethal dose : >11 gm/kg N/R AIHAAP 29,521,1968
unreported route
mouse 		lethal dose (50 percent kill): 40 gm/kg N/R USXXAM #4164653


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 70,000 mg/m3/4 hour/16 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		VCVGH* -,636,1990
inhalation
human 		lowest published toxic concentration: 4,300 mg/m3/5 day- intermittent Brain and Coverings: Recordings from specific areas of CNS VCVGH* -,637,1990
inhalation
human 		lowest published toxic concentration: 178 mg/m3/10 year- intermittent Behavioral: Headache VCVGH* -,637,1990
inhalation
rat 		lowest published toxic concentration: 20 pph/6 hour/2 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 11,68,1988
inhalation
rat 		lowest published toxic concentration: 2,000 ppm/6 hour/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TXCYAC 18,17,1980
inhalation
rat 		lowest published toxic concentration: 17,500 ppm/6 hour/13 week - intermittent Lung, Thorax, or Respiration: Changes in lung weight EPASR* #86-890000892S
inhalation
rat 		lowest published toxic concentration: 20,000 ppm/6 hour/13 week - intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight 		EPASR* #86-890000892S
multiple
guinea pig 		lowest published toxic concentration: 60 mL/kg/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TJIDAH 95,1283,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 1250 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
AIHAAP 29,521,1968


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (7600 mg/m3) DTLVS* 3,267,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (7600 mg/m3), short term exposure limit 1250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (7600 mg/m3), short term exposure limit 1250 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (7600 mg/m3), VLE 1250 ppm, JAN1999
Occupational Exposure Limit - GERMANY MAK 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 40 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1170 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (7600 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 500 ppm, short term exposure limit 5000 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 500 ppm (4000 mg/m3), KTV 750 ppm (6000 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (7600 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1000 ppm (7790 mg/m3), short term exposure limit 1250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 1250 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 1250 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 1000 ppm;
short term exposure limit 1250 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74010;
Number of Industries 175;
Total Number of Facilities 19,387;
Number of Occupations 103;
Total Number of Employees Exposed 282,795
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74010;
Number of Industries 119;
Total Number of Facilities 12,471;
Number of Occupations 103;
Total Number of Employees Exposed 250,773;
Total Number of Female Employees Exposed 79,790


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, heat transfer medium, and industrial solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2-Trichloro-1,2,2-trifluoroethane, 1020
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #113


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJIDAH Tokyo Jikeikai Ika Daigaku Zasshi. Tokyo Jikeikai Medical Journal. (3-25-8, Nishi Shinbashi, Minato-ku, Tokyo 105, Japan) V.66- 1951-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a refrigerant, heat transfer medium, and industrial solvent

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data
   Primary Irritant

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