The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - (hexyloxy) -

RTECS #: KL2450000

CAS #: 112-25-4

UPDATE: March 2000 MW: 146.26 MF: C8H18O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Cellosolve, N - hexyl -
  2. Glycol monohexyl ether
  3. Hexyl cellosolve
  4. n - Hexyl cellosolve
  1. 2 - (Hexyloxy) ethanol
  2. Ethylene glycol n - hexyl ether
  3. Ethylene glycol monohexyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg mild UCDS** 1/19/1958
skin
rabbit 		500 mg open irritation test mild UCDS** 1/19/1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >83 ppm/4 hour N/R FAATDF 8,198,1987
intraperitoneal
mouse 		lethal dose (50 percent kill): 737 mg/kg N/R ARTODN 66,368,1992
oral
rat 		lethal dose (50 percent kill): 830 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes 		VHTODE 29,361,1987
skin
rabbit 		lethal dose (50 percent kill): 810 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands

Skin: After systemic exposure: Dermatitis, other 		VHTODE 29,361,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 84 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 8,198,1987
inhalation
rat 		lowest published toxic concentration: 41 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 8,198,1987
skin
rabbit 		lowest published toxic dose: 18 mL/kg/11 day- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 14,219,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3116;
Number of Industries 3;
Total Number of Facilities 269;
Number of Occupations 4;
Total Number of Employees Exposed 3,496
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3116;
Number of Industries 5;
Total Number of Facilities 31;
Number of Occupations 7;
Total Number of Employees Exposed 2,872;
Total Number of Female Employees Exposed 45


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent in the coating industry
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as solvent in the coating industry

RTECS Compound Description:
   Primary Irritant

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