The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - ( (2 - hexyloxy) ethoxy) -

RTECS #: KL2625000

CAS #: 112-59-4

UPDATE: February 2003 MW: 190.32 MF: C10H22O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Diethylene glycol n - hexyl ether
  2. Diethylene glycol monohexyl ether
  3. 3,6 - Dioxadodecanol - 1
  4. 3,6 - Dioxa - 1 - dodecanol
  5. n - Hexoxyethoxyethanol
  1. Hexyl carbitol
  2. n - Hexyl carbitol
  3. Hexylkarbitol (Czech)
  4. 2 - ( (2 - Hexyloxy) ethoxy) ethanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg moderate UCDS** 11/3/1971
eye
rabbit 		750 µg/24 hour severe 85JCAE -,640,1986
skin
rabbit 		10 mg/24 hour open irritation test mild AMIHBC 4,119,1951
skin
rabbit 		500 mg/24 hour severe JPETAB 82,377,1944
skin
rabbit 		500 mg open irritation test mild UCDS** 11/3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		375 mg/kg (+enzymatic activation step) JAPTO* 21,449,2001
mutation in mammalian somatic cells hamster ovary 250 mg/L/5 hour (-enzymatic activation step) JAPTO* 21,449,2001
mutation in mammalian somatic cells hamster ovary 750 mg/L/5 hour (+enzymatic activation step) JAPTO* 21,449,2001
sister chromatid exchange hamster ovary 1,500 mg/L/2 hour (+enzymatic activation step) JAPTO* 21,449,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 715 mg/kg N/R JAPTO* 21,449,2001
intraperitoneal
rat 		lethal dose (50 percent kill): 1,823 mg/kg N/R JAPTO* 21,449,2001
oral
mouse 		lowest published lethal dose: 3,160 µL/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Blood: Other changes 		NTIS** OTS0538680
oral
rat 		lethal dose (50 percent kill): 2,400 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0538682
skin
rabbit 		lethal dose (50 percent kill): 1,500 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lowest published toxic dose: 18 mL/kg/11 day- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 14,219,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4280;
Number of Industries 4;
Total Number of Facilities 85;
Number of Occupations 10;
Total Number of Employees Exposed 808
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4280;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 18


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Primary Irritant

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