The Registry of Toxic Effects of Chemical Substances

Ethanol, 2,2' - iminodi -

RTECS #: KL2975000

CAS #: 111-42-2

UPDATE: February 2005 MW: 105.16 MF: C4H11NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,2' - Dihydroxydiethylamine
  2. 2,2' - Iminobisethanol
  3. 2,2' - Iminodiethanol
  4. 2 - (2 - Hydroxyethylamino) ethanol
  5. Bis (2 - hydroxyethyl) amine
  6. DEA
  7. Di (2 - hydroxyethyl) amine
  8. Diaethanolamin (German)
  1. Diethanolamin (Czech)
  2. Diethanolamine
  3. Diethanolamine (ACGIH)
  4. Diethylamine, 2,2' - dihydroxy -
  5. Diethylolamine
  6. Diolamine
  7. NCI - C55174


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5,500 mg severe AJOPAA 29,1363,1946
eye
rabbit 		750 µg/24 hour severe 85JCAE -,685,1986
skin
rabbit 		50 mg open irritation test mild UCDS** 12/29/1971
skin
rabbit 		500 mg/24 hour mild 85JCAE -,685,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis mouse liver 10 mg/L/24 hour TOXID9 72,238,2003
unscheduled DNA synthesis rat liver 10 mg/L/24 hour TOXID9 72,238,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 mg/m3/6 hour (6-15 day pregnant) Reproductive: Other effects on female NTIS** OTS0538412
oral
rat 		lowest published toxic dose: 18,382 mg/kg (14 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NIH-92-3343
oral
rat 		lowest published toxic dose: 2,800 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB2001-103718
skin
rat 		lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Other postnatal measures or effects 		RTOPDW 30,169,1999
skin
rat 		lowest published toxic dose: 15,000 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system RTOPDW 30,169,1999
skin
rabbit 		lowest published toxic dose: 4,550 mg/kg (6-18 day pregnant) Reproductive: Other effects on female RTOPDW 30,169,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 21 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-478,1999
skin
mouse 		lowest published toxic dose: 57,680 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB99-167553
skin
mouse 		lowest published toxic dose: 28,840 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB99-167553
skin
mouse 		lowest published toxic dose: 20,857 mg/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CBINA8 146,251,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lethal dose (50 percent kill): 1,500 mg/kg N/R EVSSAV 2,289,1968
intraperitoneal
mouse 		lethal dose (50 percent kill): 210 mg/kg N/R NTIS** OTS0516742
intraperitoneal
rat 		lethal dose (50 percent kill): 120 mg/kg N/R EVSSAV 2,289,1968
intravenous
rat 		lethal dose (50 percent kill): 778 mg/kg N/R EVSSAV 2,289,1968
oral
guinea pig 		lethal dose (50 percent kill): 2 gm/kg N/R 85INA8 5,197,1986
oral
mammal (species unspecified) 		lowest published lethal dose: 3 gm/kg N/R NTIS** OTS0520710
oral
mouse 		lethal dose (50 percent kill): 3,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GISAAA 29(11),25,1964
oral
rat 		lethal dose (50 percent kill): 620 µL/kg Eye: Lacrimation

Behavioral: Tremor

Skin and Appendages: Other: Hair 		NTIS** OTS0516797
oral
rabbit 		lethal dose (50 percent kill): 2,200 mg/kg N/R EVSSAV 2,289,1968
subcutaneous
rat 		lethal dose (50 percent kill): 2,200 mg/kg N/R EVSSAV 2,289,1968
skin
guinea pig 		lethal dose (50 percent kill): 11,900 µL/kg N/R NTIS** OTS0516742
skin
rabbit 		lethal dose (50 percent kill): 7,640 µL/kg Behavioral: Ataxia

Musculoskeletal: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0516797


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 30,366 mg/kg/14 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		NTPTR* NIH-92-3343
oral
mouse 		lowest published toxic dose: 38,402 mg/kg/13 week- continuous Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NTPTR* NIH-92-3343
oral
rat 		lowest published toxic dose: 52 gm/kg/14 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		NTPTR* NIH-92-3343
oral
rat 		lowest published toxic dose: 8,827 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia

Related to Chronic Data: Changes in testicular weight 		NTPTR* NIH-92-3343
oral
rat 		lowest published toxic dose: 49 gm/kg/7 week- continuous Liver: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 17,308,1970
oral
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB2001-103718
oral
rat 		lowest published toxic dose: 2,100 mg/kg/7 day- intermittent Behavioral: Sleep

Behavioral: Tremor

Skin and Appendages: Other: Hair 		NTIS** #PB2001-103718
oral
rat 		lowest published toxic dose: 800 mg/kg/4 day- intermittent Behavioral: Food intake (animal) NTIS** #PB2001-103718
oral
rat 		lowest published toxic dose: 500 mg/kg/4 day- intermittent Behavioral: Fluid intake NTIS** #PB2001-103718
oral
rat 		lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB2001-103718
oral
rat 		lowest published toxic dose: 1,750 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB2001-103718
skin
mouse 		lowest published toxic dose: 30 gm/kg/16 day- intermittent Liver: Changes in liver weight

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NIH-92-3343
skin
mouse 		lowest published toxic dose: 40,950 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NTPTR* NIH-92-3343
skin
mouse 		lowest published toxic dose: 70 mg/kg/1 week- intermittent Liver: Changes in liver weight FCTOD7 42,127,2004
skin
mouse 		lowest published toxic dose: 910 mg/kg/13 week- intermittent Tumorigenic: Cells (cultured) transformed FCTOD7 42,127,2004
skin
mouse 		lowest published toxic dose: 280 mg/kg/1 week- intermittent Liver: Other changes FCTOD7 42,127,2004
skin
mouse 		lowest published toxic dose: 1,120 mg/kg/1 week- intermittent Liver: Changes in liver weight

Tumorigenic: Cells (cultured) transformed 		FCTOD7 42,127,2004
skin
mouse 		lowest published toxic dose: 4,410 mg/kg/1 week- intermittent Skin: After topical application: Corrosive FCTOD7 42,127,2004
skin
rat 		lowest published toxic dose: 1,008 mg/kg/16 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		NTPTR* NIH-92-3343
skin
rat 		lowest published toxic dose: 8,125 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia 		NTPTR* NIH-92-3343


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 (skin) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 77,564,2000
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 3 ppm (13 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 3 ppm (13 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 3 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 3 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 3 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 3 ppm (13 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3 ppm (13 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHANOLAMINE-air 10 hour time-weighted average 3 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0517;
Number of Industries 3;
Total Number of Facilities 315;
Number of Occupations 2;
Total Number of Employees Exposed 857
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24615;
Number of Industries 147;
Total Number of Facilities 18,443;
Number of Occupations 118;
Total Number of Employees Exposed 186,455
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24615;
Number of Industries 249;
Total Number of Facilities 46,466;
Number of Occupations 171;
Total Number of Employees Exposed 828,471;
Total Number of Female Employees Exposed 218,923


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as absorbent and to make fatty alkanolamides, MORPHOLINE, plasticizers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8736;8EHQ-0293-8746
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NCI Carcinogenesis Studies (derm);clear evidence:mouse
NCI Carcinogenesis Studies (derm);no evidence:rat
NTP Toxicity studies, RPT# TOX-20, October 2000


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as absorbent and to make fatty alkanolamides, MORPHOLINE, plasticizers and resins

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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