The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - phenoxy -

RTECS #: KM0350000

CAS #: 122-99-6

UPDATE: November 2004 MW: 138.18 MF: C8H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Arosol
  2. Dowanol EP
  3. Dowanol EPH
  4. Emeressence 1160
  5. Emery 6705
  6. Glycol monophenyl ether
  7. beta - Hydroxyethyl phenyl ether
  8. 1 - Hydroxy - 2 - phenoxyethane
  9. Phenylmonoglycol ether
  10. Ethylene glycol monophenyl ether
  11. Ethylene glycol phenyl ether
  1. 2 - Fenoxyethanol (Czech)
  2. Fenyl - cellosolve (Czech)
  3. Fenylcelosolv (Czech)
  4. Phenoxethol
  5. Phenoxetol
  6. Phenoxyethanol
  7. 2 - Phenoxyethanol
  8. Phenoxyethyl alcohol
  9. Phenoxytol
  10. Phenyl cellosolve
  11. Rose ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		6 mg moderate UCDS** 6/24/1958
eye
rabbit 		250 µg/24 hour severe 85JCAE -,637,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,637,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition Escherichia coli 2,000 ppm MCBIA7 28,7,1980
other mutation test systems Escherichia coli 2,000 ppm MCBIA7 28,7,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 490 mg/kg Brain and Coverings: Other degenerative changes TOVEFN (3),37,1996
intraperitoneal
rat 		lethal dose (50 percent kill): 554 mg/kg Brain and Coverings: Other degenerative changes TOVEFN (3),37,1996
oral
mouse 		lethal dose (50 percent kill): 933 mg/kg Brain and Coverings: Other degenerative changes TOVEFN (3),37,1996
oral
rat 		lethal dose (50 percent kill): 1,260 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
skin
rat 		lethal dose (50 percent kill): 14,422 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema JACTDZ 9,259,1990
skin
rabbit 		lethal dose (50 percent kill): 5 mL/kg N/R UCDS** 6/24/1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 15 mg/m3/9 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired 		TOVEFN (3),37,1996
oral
rat 		lowest published toxic dose: 182 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JACTDZ 9(2),259,1990
oral
rat 		lowest published toxic dose: 17,500 mg/kg/14 day- intermittent Gastrointestinal: Alteration in gastric secretion

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0531470
oral
rabbit 		lowest published toxic dose: 3 gm/kg/10 day- intermittent Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0531470
skin
rabbit 		lowest published toxic dose: 14 gm/kg/14 day- intermittent Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JACTDZ 9(2),259,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
FAATDF 13,747,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 110 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83449;
Number of Industries 18;
Total Number of Facilities 711;
Number of Occupations 19;
Total Number of Employees Exposed 9,560
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83449;
Number of Industries 63;
Total Number of Facilities 5,523;
Number of Occupations 77;
Total Number of Employees Exposed 111,040;
Total Number of Female Employees Exposed 46,637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for NITROCELLULOSE, and ester type resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as solvent for NITROCELLULOSE, and ester type resins

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Mutagen
   Primary Irritant

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