The Registry of Toxic Effects of Chemical Substances

Ether, 2 - chloro - 1,1,2 - trifluoroethyl difluoromethyl

RTECS #: KN6800000

CAS #: 13838-16-9

UPDATE: November 2004 MW: 184.50 MF: C3H2ClF5O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Chloro - 1,1,2 - trifluoroethyl difluoromethyl ether
  2. 2 - Chloro - 1 - (difluoromethoxy) - 1,1,2 - trifluoroethane
  3. Anesthetic Compound No. 347
  4. Compound 347
  5. Enflurane
  6. Enflurane (ACGIH)
  1. Ethane, 2 - chloro - 1 - (difluoromethoxy) - 1,1,2 - trifluoro -
  2. Ethrane
  3. Methylflurether
  4. NSC - 115944
  5. OHIO 347


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate FEPRA7 35,729,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
chicken 		10 mg ENVRAL 12,366,1976
cytogenetic analysis human lymphocyte 1,000 ppm ENVRAL 12,366,1976
cytogenetic analysis mouse fibroblast 1,000 ppm ENVRAL 12,366,1976
other mutation test systems inhalation
rat 		1 pph/3 hour- continuous EXPEAM 35,71,1979
sperm morphology inhalation
mouse 		12,000 ppm/4 hour/5 day- intermittent ANESAV 54,53,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1 pph/4 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 19,53A,1979
inhalation
mouse 		lowest published toxic concentration: 10,000 ppm/4 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ANESAV 54,505,1981
inhalation
mouse 		lowest published toxic concentration: 10,000 ppm/4 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system ANESAV 54,505,1981
inhalation
rat 		lowest published toxic concentration: 16,500 ppm/6 hour (8-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANESAV 64,339,1986
inhalation
rat 		lowest published toxic concentration: 20 ppm/8 hour (28 day prior to copulation/1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BJANAD 53,203,1981
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour (1-20 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects AIPTAK 256,134,1982
inhalation
rat 		lowest published toxic concentration: 16,500 ppm/6 hour (11-13 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ANESAV 64,339,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 3,000 ppm/4 hour/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		ANESAV 56,9,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1 pph/6 hour Kidney, Ureter, and Bladder: Urine volume decreased or anuria ANESAV 45,557,1976
inhalation
mouse 		lethal concentration (50 percent kill): 8,100 ppm/3 hour N/R IYKEDH 12,668,1981
inhalation
rat 		lethal concentration (50 percent kill): 14,000 ppm/3 hour N/R IYKEDH 12,668,1981
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,900 µL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		YKYUA6 32,491,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 6 mL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		YKYUA6 32,491,1981
oral
mouse 		lethal dose (50 percent kill): 5 mL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		YKYUA6 32,491,1981
oral
rat 		lethal dose (50 percent kill): 5,450 µL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		YKYUA6 32,491,1981
subcutaneous
mouse 		lethal dose (50 percent kill): 38,800 µL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		YKYUA6 32,491,1981
subcutaneous
rat 		lethal dose (50 percent kill): 19,500 µL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		YKYUA6 32,491,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 170 ppm/3 hour/4 week- intermittent Liver: Other changes

Liver: Changes in liver weight 		YKYUA6 32,491,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 75 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMSUDL 7,93,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (3.8 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 75 ppm (566 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 20 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 10 ppm (80 mg/m3), KTV 20 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (80 mg/m3, KZG- week 20 ppm (160 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 153 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENFLURANE-air ceiling concentration 2 ppm/60 minute NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3127;
Number of Industries 2;
Total Number of Facilities 2,871;
Number of Occupations 12;
Total Number of Employees Exposed 86,214;
Total Number of Female Employees Exposed 73,439
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9341;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 1;
Total Number of Employees Exposed 453;
Total Number of Female Employees Exposed 329


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test; Sperm morphology-mouse
OSHA ANALYTICAL METHOD #29
OSHA ANALYTICAL METHOD #103


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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