The Registry of Toxic Effects of Chemical Substances

Ether, 2,2,2 - trifluoroethyl vinyl

RTECS #: KO4250000

CAS #: 406-90-6

UPDATE: July 2000 MW: 126.09 MF: C4H5F3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ethene, (2,2,2 - trifluoroethoxy) -
  2. Floroxene
  3. Fluooxene
  4. Fluoromar
  1. Fluoroxene
  2. Fluorxene
  3. Fluroxene
  4. 2,2,2 - Trifluoroethyl vinyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 5 pph (+enzymatic activation step) MUREAV 58,183,1978
mutation in microorganisms Salmonella typhimurium 5 pph (-enzymatic activation step) MUREAV 58,183,1978
sister chromatid exchange hamster ovary 24,700 ppm ANESAV 50,426,1979
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		2 pph/1 hour ANESAV 62,305,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
monkey 		lowest published toxic concentration: 8 pph/20 minute (22 week pregnant) Reproductive: Other effects to embryo or fetus AANEAB 20,183,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 2 pph/90 minute Liver: Jaundice, other or unclassified

Liver: Liver function tests impaired 		ANESAV 37,462,1972
inhalation
mouse 		lowest published lethal concentration: 4 pph/1 hour N/R BJANAD 48,399,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 5,600 mg/kg N/R TXAPA9 71,84,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMSUDL 7,93,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (10 mg/m3), JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUROXENE-air ceiling concentration 2 ppm/60 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M5153;
Number of Industries 1;
Total Number of Facilities 112;
Number of Occupations 3;
Total Number of Employees Exposed 448
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M5153;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 5


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an anesthetic

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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