The Registry of Toxic Effects of Chemical Substances

Ethylene, bromo -

RTECS #: KU8400000

CAS #: 593-60-2

UPDATE: May 2005 MW: 106.96 MF: C2H3Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bromoethene
  2. Bromoethene (9CI)
  3. Bromoethylene
  4. Bromure de vinyle (French)
  5. Ethene, bromo -
  6. NCI - C50373
  1. Vinile (bromuro di) (Italian)
  2. Vinyl bromide
  3. Vinyl bromide (ACGIH)
  4. Vinylbromid (German)
  5. Vinyle (bromure de) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
mouse 		2 gm/kg MUREAV 419,13,1998
mutation in microorganisms Salmonella typhimurium 2 pph/16 hour (+/-enzymatic activation step) ARTODN 41,249,1979
morphological transform inhalation
rat 		2,000 ppm/14 week- intermittent ARTODN 47,71,1981
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		14,500 ppm CRNGDP 17,1083,1996
specific locus test inhalation
Drosophila melanogaster 		54,000 ppm CRNGDP 17,1083,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors 		TXAPA9 64,367,1982
inhalation
rat 		toxic concentration (other than lowest) : 10 ppm Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		CHWKA9 123(24),25,1978
inhalation
rat 		toxic concentration (other than lowest) : 52 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors 		TXAPA9 64,367,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 50,000 ppm/7 hour N/R 85INA8 6,1690,1991
inhalation
rat 		lowest published toxic concentration: 109,000 mg/m3/7 hour Behavioral: General anesthetic VCVGH* -,599,1990
inhalation
rat 		lowest published lethal concentration: 219,000 mg/m3/7 hour N/R VCVGH* -,599,1990
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R DOWCC* -,12,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10,000 ppm/7 hour/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 31,1,1970
inhalation
rat 		lowest published toxic concentration: 250 ppm/6 hour/26 week- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight 		AIHAAP 31,1,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,133,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,923,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,133,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,923,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,923,1999
TOXICOLOGY REVIEW
VHTODE 22,31,1980


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 250 ppm (1100 mg/m3) DTLWS* 3,31,1972
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (20 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (22 mg/m3), Carcinogen JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 5 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.012 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL BROMIDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84575;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84575;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,822;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a comonomer with ACRYLONITRILE and other vinyl monomers in modacrylic fibers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 28, 1978
NIOSH Analytical Method, 1994: Vinyl bromide, 1009
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #08


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CHWKA9 Chemical Week. (McGraw-Hill, Inc., 1221 Ave. of the Americas, New York, NY 10020) V.68- 1951-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as a comonomer with ACRYLONITRILE and other vinyl monomers in modacrylic fibers

RTECS Compound Description:
   Tumorigen
   Mutagen

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