The Registry of Toxic Effects of Chemical Substances

Ethylene, 1,2 - dichloro -

RTECS #: KV9360000

CAS #: 540-59-0

UPDATE: November 2004 MW: 96.94 MF: C2H2Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Dichlor - aethen (German)
  2. 1,2 - Dichloroethene
  3. 1,2 - Dichloroethylene (ACGIH:OSHA)
  4. 1,2 - Dichloroethylene, sym -
  5. Acetylene dichloride (OSHA)
  6. Dichloro - 1,2 - ethylene (French)
  1. Dioform
  2. NCI - C56031
  3. cis - , trans - 1,2 - Dichloroethene
  4. sym - 1,2 - Dichloroethylene
  5. sym - Dichloroethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		100 mg/24 hour moderate 85JCAE -,105,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human lymphocyte 2 mmol/L MUREAV 371,185,1996
micronucleus test human lymphocyte 20 mmol/L MUREAV 371,185,1996
sex chromosome loss and nondisjunction Aspergillus nidulans 750 ppm MUREAV 266,117,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 50,000 mg/m3 Behavioral: Excitement

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		VCVGH* -,437,1990
inhalation
frog 		lowest published lethal concentration: 117 mg/m3/1 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		AISFAR 15,1,1937
inhalation
mouse 		lethal concentration (50 percent kill): 21,700 ppm/6 hour N/R VCVGH* -,437,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 2 gm/kg N/R EJTXAZ 7,247,1974
oral
mouse 		lethal dose (50 percent kill): 2,122 mg/kg N/R VCVGH* -,437,1990
oral
rat 		lethal dose (50 percent kill): 770 mg/kg N/R VCVGH* -,437,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 9 mg/kg/90 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		VCVGH* -,437,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (790 mg/m3) DTLVS* 3,80,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (790 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (793 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (790 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (790 mg/m3), short term exposure limit 250 ppm (990 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (790 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 80 mg/m3, short term exposure limit 160 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 150 ppm (590 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 790 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (395 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 150 ppm, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (790 mg/m3), KZG- week 400 ppm (1580 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (806 mg/m3), short term exposure limit 250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DICHLOROETHYLENE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03350;
Number of Industries 5;
Total Number of Facilities 896;
Number of Occupations 6;
Total Number of Employees Exposed 4,673
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03350;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 7;
Total Number of Employees Exposed 216;
Total Number of Female Employees Exposed 10


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121081/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for fats, PHENOL, CAMPHOR
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AISFAR Archivio Italiano di Scienze Farmacologiche. (Modena, Italy) V.1-11, 1932-42; Series 2: V.1-3, 1948-50; Series 3: V.1-15, 1951-65. Discontinued.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a solvent for fats, PHENOL, CAMPHOR

RTECS Compound Description:
   Mutagen
   Primary Irritant

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