The Registry of Toxic Effects of Chemical Substances

Ferrocene

RTECS #: LK0700000

CAS #: 102-54-5

UPDATE: November 2004 MW: 186.05 MF: C10H10Fe


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Biscyclopentadienyliron
  2. Catane
  3. Di - 2,4 - cyclopentadien - 1 - yliron
  4. Dicyclopentadienyl iron
  1. Dicyclopentadienyl iron (ACGIH:OSHA)
  2. Ferrotsen
  3. Iron bis (cyclopentadiene)
  4. Iron dicyclopentadienyl


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
sister chromatid exchange hamster ovary 130 µg/L ENMUDM 7,1,1985
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		100 ppm ENMUDM 7,87,1985
heritable translocation test parenteral
Drosophila melanogaster 		100 ppm ENMUDM 7,87,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 5,175 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		NCIUS* PH43-64-886


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration : >21,700 µg/m3 N/R STGNBT -,228,1999
intraperitoneal
mouse 		lethal dose (50 percent kill): 335 mg/kg N/R NCIUS* PH43-64-886
intraperitoneal
rat 		lethal dose (50 percent kill): 500 mg/kg N/R NCIUS* PH43-64-886
intravenous
mouse 		lethal dose (50 percent kill): 178 mg/kg N/R CSLNX* NX#02382
oral
mouse 		lethal dose (50 percent kill): 832 mg/kg N/R BJPCAL 24,352,1965
oral
rat 		lethal dose (50 percent kill): 1,320 mg/kg N/R SCCUR* -,5,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 15,800 µg/m3/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Fe 		STGNBT -,228,1999
inhalation
mouse 		lowest published toxic concentration: 20 mg/m3/2 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 17,150,1991
inhalation
rat 		lowest published toxic concentration: 36 mg/m3/2 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 17,150,1991
oral
dog 		lowest published toxic dose: 54,600 mg/kg/26 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Endocrine: Other changes

Nutritional and Gross Metabolic: Changes in: Fe 		TXAPA9 15,666,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENYL IRON, total dust-air time-weighted average 10 mg/m3 NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENYL IRON-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T2061;
Number of Industries 2;
Total Number of Facilities 14;
Number of Occupations 3;
Total Number of Employees Exposed 412;
Total Number of Female Employees Exposed 328


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as additive to fuel oils, as smoke suppressant, antiknock agent and catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as additive to fuel oils, as smoke suppressant, antiknock agent and catalyst

NIOSH PROFILE (METALLOCENES), SRC, 11/81

RTECS Compound Description:
   Tumorigen
   Organometallic
   Mutagen

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