The Registry of Toxic Effects of Chemical Substances

Formamidine, N' - (4 - chloro - o - tolyl) - N,N - dimethyl -

RTECS #: LQ4375000

CAS #: 6164-98-3

UPDATE: November 2003 MW: 196.70 MF: C10H13ClN2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Chlordimeform
  2. Chlorfenamidine
  3. N' - (4 - Chloro - 2 - methylphenyl) - N,N - dimethylmethanimidamide
  4. Chlorophenamidin
  5. Chlorophenamidine
  6. N' - (4 - Chloro - o - tolyl) - N,N - dimethylformamidine
  7. N (sup 2) - (4 - Chloro - o - tolyl) - N (sup 1) ,N (sup 1) - dimethylformamidine
  8. Chlorphenamidine
  9. N' - (4 - Chlor - o - tolyl) - N,N - dimethylformamidin (German)
  10. CIBA - 8514
  11. N,N - Dimethyl - N' - (2 - methyl - 4 - chlorophenyl) formamidine
  12. N,N - Dimethyl - N' - (2 - methyl - 4 - chlorphenyl) - formadin (German)
  13. ENT - 27335
  14. Acaron
  1. Bermat
  2. C 8514
  3. CDM
  4. Galecron
  5. Methanimidamide, N' - (4 - chloro - 2 - methylphenyl) - N,N - dimethyl -
  6. N' - (2 - Methyl - 4 - chlorophenyl) - N,N - dimethylformamidine
  7. SN 36268
  8. Fundal
  9. Fundal 500
  10. NSC 190935
  11. Ovatoxion
  12. RS 141
  13. Schering 36268


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe CIGET*


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human HeLa cell 1 mmol/L BECTA6 11,184,1974
mutation in microorganisms Salmonella typhimurium 2 µmol/plate (-enzymatic activation step) JAFCAU 34,157,1986
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976
other mutation test systems human HeLa cell 1 mmol/L BECTA6 11,184,1974
specific locus test multiple
Drosophila melanogaster 		10 ppb EMMUEG 25,148,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,800 µg/kg (5-22 day pregnant) Reproductive: Effects on newborn: Behavioral BECTA6 20,760,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 6,552 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Lung, Thorax, or Respiration: Tumors 		CHYCDW 19,154,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): >5,800 mg/m3/1 hour N/R 85JFAN A074,1983
intraperitoneal
hamster 		lethal dose (50 percent kill): 200 mg/kg Endocrine: Effect on menstrual cycle TXAPA9 121,279,1993
intraperitoneal
hamster 		lowest published toxic dose: 150 mg/kg Endocrine: Change in gonadotropins

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes 		TXAPA9 121,279,1993
intraperitoneal
hamster 		lowest published toxic dose: 75 mg/kg Endocrine: Other changes TXAPA9 121,279,1993
intraperitoneal
hamster 		lowest published toxic dose: 37.5 mg/kg Endocrine: Change in LH

Endocrine: Estrogenic 		TXAPA9 121,279,1993
intraperitoneal
mouse 		lethal dose (50 percent kill): 71 mg/kg N/R OYYAA2 1,78,1967
intraperitoneal
mouse 		lowest published toxic dose: 35 mg/kg Brain and Coverings: Other degenerative changes TXAPA9 93,319,1988
intraperitoneal
rat 		lethal dose (50 percent kill): 90 mg/kg N/R PSDTAP 15,239,1974
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Endocrine: Other changes TXAPA9 104,25,1990
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Endocrine: Change in gonadotropins

Endocrine: Evidence of thyroid hypofunction

Endocrine: Androgenic 		TXAPA9 104,25,1990
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg Nutritional and Gross Metabolic: Body temperature decrease LSPPAT 23,2509,1978
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation LSPPAT 23,2509,1978
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg Endocrine: Adrenal cortex hyperplasia TXCYAC 69,257,1991
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Endocrine: Change in gonadotropins

Blood: Other changes 		TXCYAC 69,257,1991
intravenous
rat 		lowest published toxic dose: 5 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		HBPTO* 1,881,2001
intravenous
rat 		lethal dose : 60 mg/kg N/R HBPTO* 1,881,2001
oral
mouse 		lethal dose (50 percent kill): 160 mg/kg N/R SPEADM 78-1,21,1978
oral
rat 		lethal dose (50 percent kill): 160 mg/kg N/R KSKZAN 16(2),59,1978
oral
rat 		lowest published toxic dose: 200 mg/kg Endocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 6,491,1992
oral
rabbit 		lethal dose (50 percent kill): 625 mg/kg N/R 28ZEAL 5,43,1976
skin
mouse 		lethal dose (50 percent kill): 225 mg/kg N/R SPEADM 78-1,21,1978
skin
rat 		lethal dose (50 percent kill): 263 mg/kg N/R FAATDF 7,299,1986
skin
rabbit 		lethal dose (50 percent kill): 640 mg/kg N/R 85DPAN -,-,1971/1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/3 day- intermittent Behavioral: Alteration of operant conditioning FAATDF 9,131,1987
oral
mouse 		lowest published toxic dose: 2,184 mg/kg/104 week- continuous Blood: Tumors HBPTO* 1,814,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,61,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,61,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEWS
ETOPFR 9,117,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,96,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
LSPPAT Life Sciences, Part 1: Physiology and Pharmacology. (New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an acaricide, insecticide, or ovicide for control of insects in agricultural uses

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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