The Registry of Toxic Effects of Chemical Substances

Formic acid, chloro - , ethyl ester

RTECS #: LQ6125000

CAS #: 541-41-3

UPDATE: November 2004 MW: 108.53 MF: C3H5ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. STANDARDS AND REGULATIONS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Chlorocarbonate d'ethyle (French)
  2. Chloroformic acid ethyl ester
  3. Clhorameisensaeureaethylester (German)
  4. ECF
  5. Ethylchloorformiaat (Dutch)
  6. Ethyl chlorocarbonate
  1. Ethyle, chloroformiat d' (French)
  2. Ethylester kyseliny chlormravenci (Czech)
  3. Etil clorocarbonato (Italian)
  4. Etil cloroformiato (Italian)
  5. TL 423


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 2,260 mg/m3/10 minute N/R NDRC** NDCrc-132,NOV1942
inhalation
rat 		lethal concentration (50 percent kill): 840 mg/m3/1 hour Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555045
intraperitoneal
mouse 		lowest published lethal dose: 15 mg/kg N/R CBCCT* 6,220,1954
oral
rat 		lethal dose (50 percent kill): 270 mg/kg N/R TXAPA9 42,417,1977
skin
rabbit 		lethal dose (50 percent kill): 7,120 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (4.5 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4.4 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4668;
Number of Industries 2;
Total Number of Facilities 250;
Number of Occupations 3;
Total Number of Employees Exposed 2,247;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of pharmaceuticals, herbicides, plastics and other organic chemicals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in synthesis of pharmaceuticals, herbicides, plastics and other organic chemicals

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