The Registry of Toxic Effects of Chemical Substances

Gasoline, natural

RTECS #: LX3300000

CAS #: 8006-61-9

UPDATE: May 2005 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Automobile regular unleaded gasoline
  2. Gasoline
  3. Gasoline (ACGIH:OSHA)
  1. Natural gasoline
  2. Petrol
  3. Petrol, natural


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		140 ppm/8 hour mild JIHTAB 25,225,1943
eye
man 		500 ppm/1 hour moderate AEHLAU 1,548,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 300 gm/m3/5 minute Lung, Thorax, or Respiration: Dyspnea NTIS** PB158-508
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 30,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
man 		lowest published toxic concentration: 900 ppm/1 hour Eye: Conjunctiva irritation

Behavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Cough 		JIHTAB 25,225,1943
inhalation
mouse 		lethal concentration (50 percent kill): 300 gm/m3/5 minute N/R NTIS** PB158-508
inhalation
rat 		lethal concentration (50 percent kill): 300 gm/m3/5 minute N/R NTIS** PB158-508
parenteral
man 		lowest published toxic dose: 53 mg/kg Skin: After systemic exposure: Dermatitis, allergic JTCTDW 21,409,1983/1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 3,200 ppm/6 hour/4 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TIHEEC 11,343,1995
inhalation
rat 		lowest published toxic concentration: 3 gm/m3/4 hour/43 week- intermittent Eye: Conjunctiva irritation VEOFA6 78(1),36,1965
oral
rat 		lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition JAPTO* 21,461,2001
oral
rat 		lowest published toxic dose: 5 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		TOLED5 44,13,1988
unreported route
man 		lowest published toxic dose: 16.5 mL/kg/7 year- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor 		DADEDV 73,183,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 300 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 500 ppm DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 45,159,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 45,159,1989
TOXICOLOGY REVIEW
NEJMAG 342,186,2000
TOXICOLOGY REVIEW
TOLED5 128,85,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Appendix A3 CFRGBR 29,1926.55,1994
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 200 ppm (800 mg/m3), KTV 300 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 500 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GASOLINE-air Carcinogen (15 ppm LOQ) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6705;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 70;
Total Number of Female Employees Exposed 7


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DADEDV Drug and Alcohol Dependence. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VEOFA6 Vestnik Oftal'mologii. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.1-34, 1884-1917; New Series V.1- 1932-

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

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