The Registry of Toxic Effects of Chemical Substances

Glucitol

RTECS #: LZ4290000

CAS #: 50-70-4

UPDATE: May 2003 MW: 182.20 MF: C6H14O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Cholaxine
  2. Diakarmon
  3. D - Glucitol
  4. Gulitol
  5. L - Gulitol
  6. Karion
  7. Sionit
  8. Sionon
  9. Sorbicolan
  1. Sorbit
  2. Sorbite
  3. Sorbitol
  4. D - Sorbitol
  5. Sorbo
  6. Sorbol
  7. Sorbostyl
  8. Sorvilande
  9. Nivitin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 300 mmol/L MUREAV 189,15,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 15 gm/kg N/R PSEBAA 35,98,1936
intravenous
mouse 		lethal dose (50 percent kill): 9,480 mg/kg N/R YKYUA6 32,1367,1981
intravenous
rat 		lethal dose (50 percent kill): 7,100 mg/kg N/R FAONAU 53A,498,1974
oral
human 		lowest published toxic dose: 1,167 mg/kg Gastrointestinal: Other changes FCTOD7 37,233,1999
oral
mouse 		lethal dose (50 percent kill): 17,800 mg/kg N/R YKYUA6 32,1367,1981
oral
rat 		lethal dose (50 percent kill): 15,900 mg/kg N/R FAONAU 53A,498,1974
oral
woman 		lowest published toxic dose: 1,700 mg/kg/ day Gastrointestinal: Hypermotility, diarrhea AJDDAL 23,568,1978
subcutaneous
mouse 		lethal dose (50 percent kill): 24 gm/kg N/R NIIRDN -,607,1990
subcutaneous
rat 		lethal dose (50 percent kill): 29,600 mg/kg N/R NIIRDN -,607,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80530;
Number of Industries 86;
Total Number of Facilities 16,621;
Number of Occupations 80;
Total Number of Employees Exposed 144,563
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80530;
Number of Industries 126;
Total Number of Facilities 18,220;
Number of Occupations 121;
Total Number of Employees Exposed 669,284;
Total Number of Female Employees Exposed 461,984


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJDDAL American Journal of Digestive Diseases. (New York, NY) V.5-22, 1938-55; New series: V.1-23, 1956-78. For publisher information, see DDSCDJ.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as humectant chelating agent and sweetener, sugarless gum, toothpaste, in cosmetics

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

ALT CAS #: 36134-87-9
ALT CAS #: 63800-20-4
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