The Registry of Toxic Effects of Chemical Substances

Guanidine, cyano -

RTECS #: ME9950000

CAS #: 461-58-5

UPDATE: March 1999 MW: 84.10 MF: C2H4N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. ACR - H 3636
  2. Araldite HT 986
  3. Araldite XB 2879B
  4. Araldite XB 2979B
  5. Bakelite VE 2560
  6. Dicyandiamide
  7. Dicyandiamin (German)
  1. Dicyanodiamide
  2. Epicure DICY 7
  3. Epicure DICY 15
  4. Cyanoguanidine
  5. N - Cyanoguanidine
  6. 1 - Cyanoguanidine
  7. XB 2879B


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >4 gm/kg N/R APTOA6 8,329,1952
intraperitoneal
rabbit 		lethal dose (50 percent kill): >3 gm/kg N/R APTOA6 8,329,1952
oral
mouse 		lethal dose (50 percent kill): >10 gm/kg N/R TOVEFN (4),39,1998
oral
rat 		lethal dose : >500 mg/kg N/R NCNSA6 5,17,1953
unreported route
rat 		lowest published lethal dose: 600 mg/kg N/R BCPCA6 14,1325,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 2,400 µg/m3/4 week- intermittent Blood: Other changes TOVEFN (4),39,1998
inhalation
rat 		lowest published toxic concentration: 2,400 µg/m3/4 week- intermittent Blood: Other changes TOVEFN (4),39,1998
oral
rat 		lowest published toxic dose: 273 gm/kg/13 week- continuous Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		ESKHA5 (109),61,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83038;
Number of Industries 27;
Total Number of Facilities 720;
Number of Occupations 55;
Total Number of Employees Exposed 19,281
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83038;
Number of Industries 48;
Total Number of Facilities 1,639;
Number of Occupations 50;
Total Number of Employees Exposed 35,475;
Total Number of Female Employees Exposed 7,043


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC)
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

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