The Registry of Toxic Effects of Chemical Substances
Guanidine, monohydrochloride RTECS #: MF4300000
CAS #: 50-01-1
The Registry of Toxic Effects of Chemical Substances
Guanidine, monohydrochloride |
| UPDATE: January 1997 | MW: 95.55 | MF: CH5N3•ClH |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
81,400 µg
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moderate
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NTIS** AD-A184-068
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skin | rabbit
500 mg/24 hour
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severe
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NTIS** AD-A166-306
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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mutation in microorganisms
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Saccharomyes cerevisiae
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4 mmol/L (-enzymatic activation step)
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BBRCA9 53,531,1973
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraarterial | guinea pig
lowest published lethal dose: 500 mg/kg
|
N/R
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AEPPAE 131,171,1928
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intraperitoneal | mouse
lethal dose (50 percent kill): 500 mg/kg
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N/R
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NTIS** AD277-689
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intravenous | guinea pig
lowest published lethal dose: 500 mg/kg
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N/R
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AEPPAE 131,171,1928
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oral | mammal (species unspecified)
lowest published lethal dose: 300 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea
JIDHAN 13,87,1931
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oral | mouse
lethal dose (50 percent kill): 571 mg/kg
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Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Muscle contraction or spasticity Behavioral: Irritability
ATDAEI 12,598,1993
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oral | rat
lethal dose (50 percent kill): 475 mg/kg
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Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Excitement Gastrointestinal: Hypermotility, diarrhea
NTIS** AD-A165-747
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subcutaneous | dog
lowest published lethal dose: 200 mg/kg
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N/R
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HBAMAK 4,1352,1935
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subcutaneous | guinea pig
lowest published lethal dose: 100 mg/kg
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N/R
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HBAMAK 4,1352,1935
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subcutaneous | rat
lowest published lethal dose: 404 mg/kg
|
N/R
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JPETAB 28,251,1926
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skin | rabbit
lethal dose : >2 gm/kg
|
N/R
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ATDAEI 12,596,1993
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
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N/R
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REVIEWS:
ORGANIZATION
|
STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X3755 |
 ;Number of Industries 2; Total Number of Facilities 115; Number of Occupations 22; Total Number of Employees Exposed 2,097; Total Number of Female Employees Exposed 589 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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REFERENCES:
CODEN
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REFERENCE
AEPPAE
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Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.)
V.110-253, 1925-66. For publisher information, see NSAPCC.
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ATDAEI
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Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
|
BBRCA9
|
Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959-
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HBAMAK
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"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
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JIDHAN
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Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information,
see AEHLAU.
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JPETAB
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Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E.
Preston St., Baltimore, MD 21202) V.1- 1909/10-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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