The Registry of Toxic Effects of Chemical Substances

3 - Heptanone

RTECS #: MJ5250000

CAS #: 106-35-4

UPDATE: November 2004 MW: 114.21 MF: C7H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Heptanone (OSHA)
  2. Aethylbutylketon (German)
  3. Butyl ethyl ketone
  4. Eptan - 3 - one (Italian)
  5. Ethyl butyl ketone
  6. Ethyl butyl ketone (ACGIH:OSHA)
  1. Ethylbutylcetone (French)
  2. Ethylbutylketon (Dutch)
  3. Etilbutilchetone (Italian)
  4. Heptan - 3 - on (Dutch, German)
  5. Heptan - 3 - one
  6. n - Butyl ethyl ketone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild FCTXAV 16,731,1978
eye
rabbit 		500 mg/24 hour mild 85JCAE -,286,1986
skin
rabbit 		500 mg open irritation test mild UCDS** 3/12/1969
skin
rabbit 		500 mg/24 hour moderate FCTXAV 16,731,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/4 hour N/R JIHTAB 31,343,1949
oral
rat 		lethal dose (50 percent kill): 2,760 mg/kg N/R JIHTAB 31,60,1949
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 3/12/1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,863 mg/m3/16 hour/4 day- intermittent Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath 		VCVGK* -,430,1994
oral
rat 		lowest published toxic dose: 140,000 mg/kg/14 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath 		VCVGK* -,430,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 75 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 75 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (230 mg/m3) DTLVS* 3,105,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (230 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (230 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (230 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (230 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (230 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (234 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 163 mg/m3, 2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3), short term exposure limit 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (237 mg/m3), short term exposure limit 100 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 75 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 75 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL BUTYL KETONE-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 36330;
Number of Industries 8;
Total Number of Facilities 320;
Number of Occupations 14;
Total Number of Employees Exposed 1,923
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 36330;
Number of Industries 20;
Total Number of Facilities 2,103;
Number of Occupations 9;
Total Number of Employees Exposed 11,318;
Total Number of Female Employees Exposed 1,164


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Primary Irritant

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