The Registry of Toxic Effects of Chemical Substances

3 - Heptanone, 5 - methyl -

RTECS #: MJ7350000

CAS #: 541-85-5

UPDATE: November 2004 MW: 128.24 MF: C8H16O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Methylbutyl ethyl ketone
  2. 3 - Methyl - 5 - heptanone
  3. 5 - Methyl - 3 - heptanone (OSHA)
  4. Ethyl 2 - methylbutyl ketone
  1. Ethyl amyl ketone
  2. Ethyl amyl ketone (ACGIH)
  3. Ethyl sec - amyl ketone (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg mild SCCUR* -,6,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 3,484 ppm/4 hour N/R SCCUR* -,6,1961
inhalation
rat 		lowest published lethal concentration: 3,484 ppm/8 hour N/R SCCUR* -,6,1961
oral
guinea pig 		lethal dose (50 percent kill): 2,500 mg/kg N/R BCPCA6 16,631,1967
oral
mouse 		lethal dose (50 percent kill): 3,800 mg/kg N/R SCCUR* -,6,1961
oral
rat 		lethal dose (50 percent kill): 3,500 mg/kg N/R SCCUR* -,6,1961
skin
rabbit 		lethal dose (50 percent kill): >16 gm/kg N/R SHELL* MSDS 540-1


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (130 mg/m3) DTLVS* 3,104,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (130 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (130 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (130 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (130 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (131 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (130 mg/m3), CEILING 50 ppm (260 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 133 mg/m3, 2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (130 mg/m3), short term exposure limit 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (133 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL AMYL KETONE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83448;
Number of Industries 26;
Total Number of Facilities 1,523;
Number of Occupations 22;
Total Number of Employees Exposed 19,792


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301


REFERENCES:

CODEN
REFERENCE
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
SHELL* Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210)

RTECS Compound Description:
   Primary Irritant

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