The Registry of Toxic Effects of Chemical Substances

Hexamethylenetetramine

RTECS #: MN4725000

CAS #: 100-97-0

UPDATE: November 2003 MW: 140.22 MF: C6H12N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aceto HMT
  2. Aminoform
  3. Ammoform
  4. Ammonioformaldehyde
  5. Cystogen
  6. Esametilentetramina (Italian)
  7. Formamine
  8. Formin
  9. Hexamethylenetetraamine
  10. Cystamin
  11. Hexaform
  12. Hexamethylenamine
  13. Hexamethyleneamine
  1. Hexamethylentetramin (German)
  2. Hexamethylentetramine
  3. Hexilmethylenamine
  4. HMT
  5. Methamin
  6. Methenamine
  7. Preparation AF
  8. Resotropin
  9. 1,3,5,7 - Tetraazaadamantane
  10. 1,3,5,7 - Tetraazatricyclo (3.3.1.1 (sup 37) ) decane
  11. Uritone
  12. Urotropin
  13. Urotropine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human HeLa cell 1 mmol/L HUMAA7 4,112,1967
dominant lethal test intraperitoneal
mouse 		25 gm/kg DMWOAX 92,2315,1967
dominant lethal test oral
mouse 		25 gm/kg HUMAA7 4,112,1967
DNA repair Bacillus subtilis 1 mg/disc SAIGBL 26,147,1984
DNA repair Escherichia coli 6 mg/well/16 hour CBINA8 15,219,1976
mutation in microorganisms Salmonella typhimurium 10 mg/plate (+/-enzymatic activation step) SAIGBL 27,400,1985
morphological transform hamster kidney 10 mg/L CRNGDP 4,457,1983
other mutation test systems human HeLa cell 100 µmol/L HUMAA7 4,112,1967


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 140 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		FAONAU 50A,71,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 17,700 µL/kg N/R ANTBAL 20,891,1975
intravenous
rat 		lethal dose (50 percent kill): 9,200 mg/kg N/R AEPPAE 221,166,1954
oral
mouse 		lethal dose (50 percent kill): 569 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GISAAA 35(3),115,1970
parenteral
cat 		lowest published lethal dose: 200 mg/kg N/R IPSTB3 3,93,1976
parenteral
mammal (species unspecified) 		lowest published lethal dose: 300 mg/kg N/R IPSTB3 3,93,1976
parenteral
mouse 		lowest published lethal dose: 450 mg/kg N/R IPSTB3 3,93,1976
parenteral
rat 		lowest published lethal dose: 200 mg/kg N/R IPSTB3 3,93,1976
subcutaneous
cat 		lowest published lethal dose: 200 mg/kg N/R HBTXAC 1,84,1955
subcutaneous
guinea pig 		lowest published lethal dose: 300 mg/kg N/R HBTXAC 1,84,1955
subcutaneous
mouse 		lethal dose (50 percent kill): 215 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands 		AEPPAE 225,428,1955
subcutaneous
rat 		lowest published lethal dose: 200 mg/kg N/R HBTXAC 1,84,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 350 mg/m3/2 hour/3 week- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 35(3),115,1970
inhalation
rat 		lowest published toxic concentration: 350 mg/m3/2 hour/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,227,1994
oral
rabbit 		lowest published toxic dose: 525 mg/kg/15 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,227,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 4 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 3 mg/m3, KTV 5 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33675;
Number of Industries 49;
Total Number of Facilities 3,087;
Number of Occupations 59;
Total Number of Employees Exposed 30,437
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33675;
Number of Industries 81;
Total Number of Facilities 9,101;
Number of Occupations 86;
Total Number of Employees Exposed 188,300;
Total Number of Female Employees Exposed 40,283


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a methylenating agent, as an intermediate, and an accelerator
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.) V.1-104, 1875-1979.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ.
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a methylenating agent, as an intermediate, and an accelerator

NIOSH PROFILE (AMINES, TERTIARY AROMATIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

ALT CAS #: 74734-16-0
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