The Registry of Toxic Effects of Chemical Substances

Hexanoic acid

RTECS #: MO5250000

CAS #: 142-62-1

UPDATE: July 2000 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Hexacid 698
  2. Butylacetic acid
  3. n - Caproic acid
  4. Capronic acid
  5. n - Hexanoic acid
  1. Kyselina kapronova (Czech)
  2. n - Hexoic acid
  3. Pentanecarboxylic acid
  4. Pentylformic acid
  5. Pentiformic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg severe AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test mild AMIHBC 10,61,1954
skin
rabbit 		465 mg open irritation test mild UCDS** 11/2/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis non-mammalian species other cell types 10 mmol/L CHROAU 40,1,1973
other mutation test systems non-mammalian species other cell types 10 mmol/L CHROAU 40,1,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 4,100 mg/m3/2 hour N/R 85GMAT -,32,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
intravenous
mouse 		lethal dose (50 percent kill): 1,725 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		APTOA6 18,141,1961
oral
mouse 		lethal dose (50 percent kill): 5 gm/kg N/R 85GMAT -,32,1982
oral
rat 		lethal dose (50 percent kill): 2,050 µL/kg N/R UCDS** 11/2/1971
subcutaneous
mouse 		lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
skin
guinea pig 		lethal dose (50 percent kill): 5 mL/kg N/R JIHTAB 26,269,1944
skin
rabbit 		lethal dose (50 percent kill): 630 µL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 25,200 mg/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84192;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 7;
Total Number of Employees Exposed 1,526
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84192;
Number of Industries 8;
Total Number of Facilities 735;
Number of Occupations 14;
Total Number of Employees Exposed 10,060;
Total Number of Female Employees Exposed 3,562


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of esters for artificial flavors and of hexyl derivatives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the manufacture of esters for artificial flavors and of hexyl derivatives

RTECS Compound Description:
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS