The Registry of Toxic Effects of Chemical Substances

Hexanoic acid, 2 - ethyl -

RTECS #: MO7700000

CAS #: 149-57-5

UPDATE: May 2004 MW: 144.24 MF: C8H16O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Butylbutanoic acid
  2. 2 - Ethylcaproic acid
  3. 2 - Ethylhexanoic acid
  4. 2 - Ethylhexanoic - acid
  5. 2 - Ethylhexoic acid
  1. 3 - Heptanecarboxylic acid
  2. Butylethylacetic acid
  3. Kyselina 2 - ethylkapronova (Czech)
  4. Kyselina heptan - 3 - karboxylova (Czech)
  5. alpha - Ethylcaproic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg severe AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit 		450 mg open irritation test mild UCDS** 11/4/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 630 µmol/L MUREAV 279,75,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,803 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 35,41,1987
oral
rat 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 20,199,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >400 ppm/6 hour N/R KODAK* 21MAY1971
oral
rat 		lethal dose (50 percent kill): 3 gm/kg N/R JIHTAB 26,269,1944
skin
guinea pig 		lethal dose (50 percent kill): 6,300 µL/kg N/R JIHTAB 26,269,1944
skin
rabbit 		lethal dose (50 percent kill): 1,260 µL/kg N/R UCDS** 11/4/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 81,116 mg/kg/2 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0525547
oral
mouse 		lowest published toxic dose: 79,650 mg/kg/90 day- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0543763
oral
rat 		lowest published toxic dose: 25,200 mg/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982
oral
rat 		lowest published toxic dose: 8,800 mg/kg/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Skin and Appendages: Other: Hair 		NTIS** OTS0525547
oral
rat 		lowest published toxic dose: 82,530 mg/kg/90 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0543763
oral
rat 		lowest published toxic dose: 27.2 gm/kg/14 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		ARTODN Suppl.12,274,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 ( intermittent,V) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84204;
Number of Industries 23;
Total Number of Facilities 711;
Number of Occupations 28;
Total Number of Employees Exposed 15,851
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84204;
Number of Industries 135;
Total Number of Facilities 15,863;
Number of Occupations 89;
Total Number of Employees Exposed 176,189;
Total Number of Female Employees Exposed 20,117


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0593-9057
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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