RTECS:MQ4025000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

Hexyl alcohol

RTECS #: MQ4025000

CAS #: 111-27-3

UPDATE: August 2003 MW: 102.20 MF: C₆H₁₄O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Amylcarbinol

EPAL 6

Caproyl alcohol

Hexanol

n - Hexanol

1 - Hexanol

n - Hexyl alcohol

1 - Hydroxyhexane

Pentylcarbinol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rabbit 410 mg open irritation test mild UCDS 4/21/1967

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
inhalation
guinea pig lethal concentration : >1,060 ppm/6 hour N/R FCTXAV 13,695,1975
inhalation
human lowest published toxic concentration: 270 mg/m³ Lung, Thorax, or Respiration: Cough VCVGK* -,111,1984
inhalation
mouse lethal concentration : >1,060 ppm/6 hour N/R FCTXAV 13,695,1975
inhalation
rat lethal dose : >1,060 ppm/6 hour N/R FCTXAV 13,695,1975
intraperitoneal
rat lowest published toxic dose: 170 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Ataxia

Behavioral: Tetany VCVGK* -,110,1984
intravenous
mouse lethal dose (50 percent kill): 103 mg/kg N/R AIPTAK 135,330,1962
oral
mouse lethal dose (50 percent kill): 1,950 mg/kg N/R HYSAAV 31(1-3),310,1966
oral
mouse lethal dose (50 percent kill): 1,950 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea VCVGK* -,110,1984
oral
mouse lowest published lethal dose: 1,000 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea VCVGK* -,110,1984
oral
rat lethal dose (50 percent kill): 720 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes SAMJAF 43,795,1969
oral
rat lethal dose (50 percent kill): 710 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea VCVGK* -,110,1984
skin
rabbit lethal dose (50 percent kill): 3,100 無/kg N/R AMIHBC 4,119,1951
unreported route
mammal (species unspecified) lethal dose (50 percent kill): 2,442 mg/kg N/R GISAAA 51(5),61,1986

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified) lowest published toxic concentration: 118 mg/m³/4 hour/28 week- intermittent Liver: Other changes

Brain and Coverings: Other degenerative changes

Eye: Optic nerve neuropathy VCVGK* -,111,1994
intraperitoneal
rat lowest published toxic dose: 18,450 mg/kg/30 week- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve TXAPA9 46,421,1978
oral
dog lowest published toxic dose: 91 gm/kg/13 week- intermittent Behavioral: Tremor

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS OTS0555542
oral
rat lowest published toxic dose: 101 gm/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982
oral
rabbit lowest published toxic dose: 9,100 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 31(1-3),310,1966

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE**

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,291,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0244;
Number of Industries 12;
Total Number of Facilities 3,205;
Number of Occupations 22;
Total Number of Employees Exposed 20,684
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0244;
Number of Industries 23;
Total Number of Facilities 1,126;
Number of Occupations 34;
Total Number of Employees Exposed 27,055;
Total Number of Female Employees Exposed 8,574

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, plasticizer intermediate, specialty ethoxylate intermediate, defoamer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent, plasticizer intermediate, specialty ethoxylate intermediate, defoamer

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
Human Data
Primary Irritant

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rabbit	410 mg open irritation test	mild	UCDS** 4/21/1967

SYNONYMS:
Amylcarbinol EPAL 6 Caproyl alcohol Hexanol n - Hexanol	1 - Hexanol n - Hexyl alcohol 1 - Hydroxyhexane Pentylcarbinol

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation guinea pig	lethal concentration : >1,060 ppm/6 hour	N/R	FCTXAV 13,695,1975
inhalation human	lowest published toxic concentration: 270 mg/m³	Lung, Thorax, or Respiration: Cough	VCVGK* -,111,1984
inhalation mouse	lethal concentration : >1,060 ppm/6 hour	N/R	FCTXAV 13,695,1975
inhalation rat	lethal dose : >1,060 ppm/6 hour	N/R	FCTXAV 13,695,1975
intraperitoneal rat	lowest published toxic dose: 170 mg/kg	Brain and Coverings: Changes in circulation Behavioral: Ataxia Behavioral: Tetany	VCVGK* -,110,1984
intravenous mouse	lethal dose (50 percent kill): 103 mg/kg	N/R	AIPTAK 135,330,1962
oral mouse	lethal dose (50 percent kill): 1,950 mg/kg	N/R	HYSAAV 31(1-3),310,1966
oral mouse	lethal dose (50 percent kill): 1,950 mg/kg	Brain and Coverings: Changes in circulation Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,110,1984
oral mouse	lowest published lethal dose: 1,000 mg/kg	Brain and Coverings: Changes in circulation Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,110,1984
oral rat	lethal dose (50 percent kill): 720 mg/kg	Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes Blood: Other changes	SAMJAF 43,795,1969
oral rat	lethal dose (50 percent kill): 710 mg/kg	Brain and Coverings: Changes in circulation Behavioral: Tetany Lung, Thorax, or Respiration: Dyspnea	VCVGK* -,110,1984
skin rabbit	lethal dose (50 percent kill): 3,100 無/kg	N/R	AMIHBC 4,119,1951
unreported route mammal (species unspecified)	lethal dose (50 percent kill): 2,442 mg/kg	N/R	GISAAA 51(5),61,1986

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mammal (species unspecified)	lowest published toxic concentration: 118 mg/m³/4 hour/28 week- intermittent	Liver: Other changes Brain and Coverings: Other degenerative changes Eye: Optic nerve neuropathy	VCVGK* -,111,1994
intraperitoneal rat	lowest published toxic dose: 18,450 mg/kg/30 week- intermittent	Peripheral Nerve and Sensation: Sensory change involving peripheral nerve	TXAPA9 46,421,1978
oral dog	lowest published toxic dose: 91 gm/kg/13 week- intermittent	Behavioral: Tremor Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0555542
oral rat	lowest published toxic dose: 101 gm/kg/3 week- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOLED5 10,379,1982
oral rabbit	lowest published toxic dose: 9,100 mg/kg/26 week- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HYSAAV 31(1-3),310,1966

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: Cancelled	RBREV* -,291,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M0244; Number of Industries 12; Total Number of Facilities 3,205; Number of Occupations 22; Total Number of Employees Exposed 20,684
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M0244; Number of Industries 23; Total Number of Facilities 1,126; Number of Occupations 34; Total Number of Employees Exposed 27,055; Total Number of Female Employees Exposed 8,574

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, plasticizer intermediate, specialty ethoxylate intermediate, defoamer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AIPTAK	Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV	Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAMJAF	South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS**	Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.