The Registry of Toxic Effects of Chemical Substances

Hydantoin, 1,3 - dichloro - 5,5 - dimethyl -

RTECS #: MU0700000

CAS #: 118-52-5

UPDATE: November 2004 MW: 197.03 MF: C5H6Cl2N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3 - Dichloro - 5,5' - methylhydantoin
  2. 1,3 - Dichloro - 5,5 - dimethyl hydantoin
  3. 1,3 - Dichloro - 5,5 - dimethyl hydantoin (ACGIH:OSHA)
  4. 1,3 - Dichloro - 5,5 - dimethyl - 2,4 - imidazolidinedione
  5. 1,3 - Dichloro - 5,5 - dimethylhydantoin
  6. 1,3 - Dwuchloro - 5,5 - dwumetylohydantoina (Polish)
  7. 2,4 - Imidazolidinedione, 1,3 - dichloro - 5,5 - dimethyl - (9CI)
  8. Dactin
  9. Daktin
  1. Dantoin
  2. Dichlorantin
  3. Dwuchlorantyny (Polish)
  4. Halane
  5. Hydan
  6. Hydan (antiseptic)
  7. Hydantoin, dichlorodimethyl -
  8. NCI - C03054
  9. Omchlor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour severe EPASR* 8EHQ-0281-0382
skin
rabbit 		100 mg/24 hour severe EPASR* 8EHQ-0281-0382


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform rat embryo 6,300 ng/plate JJATDK 1,190,1981
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		250 ppm ENMUDM 7,677,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 20 gm/m3/1 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		EPASR* 8EHQ-0281-0382
oral
guinea pig 		lethal dose (50 percent kill): 1,350 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 47(6),76,1982
oral
rat 		lethal dose (50 percent kill): 542 mg/kg N/R 85INA8 5,183,1986
oral
rabbit 		lethal dose (50 percent kill): 1,520 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 47(6),76,1982
skin
rabbit 		lethal dose (50 percent kill): >20 gm/kg N/R EPASR* 8EHQ-0281-0382
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 500 mg/kg N/R GWXXBX #2550828
unreported route
rat 		lethal dose (50 percent kill): 550 mg/kg N/R BCTKAG 19,52,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 8,784 mg/kg/28 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BCTKAG 19,52,1986
oral
rat 		lowest published toxic dose: 634 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 47(6),76,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.4 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,78,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.4 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.4 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 0.2 mg/m3;
short term exposure limit 0.4 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24100;
Number of Industries 5;
Total Number of Facilities 729;
Number of Occupations 6;
Total Number of Employees Exposed 2,224
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24100;
Number of Industries 9;
Total Number of Facilities 436;
Number of Occupations 10;
Total Number of Employees Exposed 3,502;
Total Number of Female Employees Exposed 1,780


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a bleach and biocide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a bleach and biocide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Primary Irritant

ALT CAS #: 55945-60-3
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