The Registry of Toxic Effects of Chemical Substances

Hydroperoxide, alpha,alpha - dimethylbenzyl -

RTECS #: MX2450000

CAS #: 80-15-9

UPDATE: November 2004 MW: 152.21 MF: C9H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 7 - Hydroperoxykumen (Czech)
  2. CHP
  3. Cumeenhydroperoxyde (Dutch)
  4. Cumene hydroperoxide
  5. Cumenyl hydroperoxide
  6. Cumolhydroperoxid (German)
  7. Cumyl hydroperoxide
  8. Hydroperoxyde de cumene (French)
  1. Hydroperoxyde de cumyle (French)
  2. Idroperossido di cumene (Italian)
  3. Idroperossido di cumolo (Italian)
  4. Isopropylbenzene hydroperoxide
  5. Kumenylhydroperoxid (Czech)
  6. RCRA waste number U096
  7. alpha,alpha - Dimethylbenzyl hydroperoxide
  8. alpha - Cumyl hydroperoxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg N/R AIHAAP 19,205,1958
eye
rabbit 		70 % VCVGK* -,533,1994
skin
rabbit 		500 mg % AIHAAP 19,205,1958
skin
rabbit 		500 mg mild SCCUR* -,3,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
mouse 		750 µmol/kg/5 day- continuous MUREAV 444,145,1999
DNA damage other fish sperm 20 µmol/L/2 hour FCTOD7 39,1205,2001
mutation in microorganisms Escherichia coli 12,500 ng/plate (-enzymatic activation step) MUREAV 467,41,2000
mutation in microorganisms Escherichia coli 40 µg/plate/20 minute MUREAV 492,91,2001
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) PNASA6 79,7445,1982
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) ABCHA6 44,1989,1980
mutation in microorganisms Salmonella typhimurium 50 µg/plate/44 hour FCTOD7 40,105,2002
mutation in microorganisms Salmonella typhimurium 100 µg/plate/48 hour MUREAV 540,1,2003
gene conversion and mitotic recombination Saccharomyes cerevisiae 47 mg/L MUREAV 308,159,1994
other mutation test systems Escherichia coli 10 µmol/L MUREAV 203,81,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 8,844 mg/kg/67 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 37,825,1966
unreported route
mouse 		lowest published toxic dose: 304 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 0.2 mg/m3 Eye: Other eye effects VCVGK* -,532,1994
inhalation
mouse 		lethal concentration (50 percent kill): 200 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
mouse 		lowest published toxic concentration: 100 mg/m3/2 hour Olfaction: Other olfaction effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		VCVGK* -,532,1994
inhalation
mouse 		lowest published toxic concentration: 55 mg/m3/2 hour Blood: Changes in leukocyte (WBC) count VCVGK* -,532,1994
inhalation
rat 		lethal concentration (50 percent kill): 220 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 270 mg/kg N/R VCVGK* -,532,1994
intraperitoneal
rat 		lethal dose (50 percent kill): 95 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia 		AIHAAP 19,205,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 235 mg/kg Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		VCVGK* -,532,1994
oral
mouse 		lowest published lethal dose: 5 gm/kg N/R SCCUR* -,3,1961
oral
mouse 		lethal dose (50 percent kill): 342 mg/kg N/R VCVGK* -,531,1994
oral
rat 		lethal dose (50 percent kill): 382 mg/kg Kidney, Ureter, and Bladder: Hematuria AIHAAP 19,205,1958
oral
rat 		lethal dose (50 percent kill): 800 mg/kg N/R VCVGK* -,531,1994
subcutaneous
mouse 		lethal dose (50 percent kill): 490 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 26(12),22,1961
subcutaneous
rat 		lethal dose (50 percent kill): 382 mg/kg N/R 85JCAE -,242,1986
skin
mouse 		lethal dose (50 percent kill): 490 mg/kg N/R VCVGK* -,532,1994
skin
mouse 		lowest published toxic dose: 1,200 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		JOETD7 85,33,2003
skin
rat 		lethal dose (50 percent kill): 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria 		AEHLAU 30,1,1975
skin
rabbit 		lowest published lethal dose: 1,200 mg/kg Cardiac: Pulse rate increased without fall in BP

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Body temperature decrease 		GTPZAB 8(8),12,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 50 ppm/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BJIMAG 27,1,1970
intraperitoneal
rat 		lowest published toxic dose: 399 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958
oral
rat 		lowest published toxic dose: 1,604 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1346;
Number of Industries 80;
Total Number of Facilities 4,311;
Number of Occupations 53;
Total Number of Employees Exposed 95,676
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1346;
Number of Industries 125;
Total Number of Facilities 10,989;
Number of Occupations 85;
Total Number of Employees Exposed 234,305;
Total Number of Female Employees Exposed 69,933


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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