RTECS:NL1400000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Indium chloride

RTECS #: NL1400000

CAS #: 10025-82-8

UPDATE: November 2004 MW: 221.17 MF: Cl₃In

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Indium trichloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA damage mammal (species unspecified) lymphocyte 40 痠ol/L JCHODP 7,411,1976

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intravenous
mouse lowest published toxic dose: 0.8 mg(In)/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TCMUD8 20,219,2000
intravenous
mouse lowest published toxic dose: 1.6 mg(In)/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death TCMUD8 20,219,2000
intravenous
rat lowest published toxic dose: 400 痢/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system TCMUD8 18,231,1998
intravenous
rat lowest published toxic dose: 0.4 mg(In)/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system TCMUD8 20,219,2000
intravenous
rat lowest published toxic dose: 0.4 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death TCMUD8 18,231,1998
oral
mouse lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 27,140,1995
oral
mouse lowest published toxic dose: 2,250 mg/kg (6-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TOXID9 12,103,1992
oral
rat lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHF8 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities JTEHF8 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 1,500 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 6,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 400 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000
oral
rabbit lowest published toxic dose: 3 gm/kg (6-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHF8 59,27,2000
oral
rabbit lowest published toxic dose: 1,500 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JTEHD6 59,27,2000
oral
rabbit lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000
oral
rabbit lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 59,27,2000

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 4,950 痢/kg N/R COREAF 256,1043,1963
intraperitoneal
rat lethal dose (50 percent kill): 2,370 痢/kg N/R NIIRDN -,136,1990
intravenous
mouse lethal dose (50 percent kill): 11,900 痢/kg N/R NIIRDN -,136,1990
intravenous
mouse lowest published toxic dose: 16.5 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVN1* -,233,1988
intravenous
rat lethal dose (50 percent kill): 4,460 痢/kg N/R NIIRDN -,136,1990
intravenous
rat lowest published toxic dose: 3.6 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVN1* -,233,1988
intravenous
rabbit lowest published lethal dose: 0.64 mg/kg N/R VCVN1* -,232,1988
subcutaneous
mouse lowest published lethal dose: 60 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
rat lowest published lethal dose: 10 mg/kg Olfaction: Other olfaction effects

Skin and Appendages: Other: Hair JIHTAB 24,243,1942
subcutaneous
rat lowest published lethal dose: 10 mg/kg N/R VCVN1* -,232,1988
subcutaneous
rabbit lowest published lethal dose: 2 mg/kg N/R VCVN1* -,232,1988

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 200 mg/kg/2 day- intermittent Behavioral: Food intake (animal) JTEHD6 59,27,2000
oral
rat lowest published toxic dose: 6,000 mg/kg/15 day- intermittent Brain and Coverings: Changes in brain weight

Gastrointestinal: Changes in pancreatic weight

Liver: Changes in liver weight JTEHD6 59,27,2000
oral
rabbit lowest published toxic dose: 3,000 mg/kg/15 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 59,27,2000

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(In)/m³ CFRGBR 29,1926.55,1994
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(In)/m³, short term exposure limit 0.3 mg(In)/m³, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg(In)/m³, 2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5168;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 14

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JCHODP Journal of Clinical Hematology and Oncology. (Cancer Center at Wadley Institutes, POB 35988, Dallas, TX 75235) V.5(3)- 1975-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (INDIUM AND ITS COMPOUNDS), SRC, 4/78

RTECS Compound Description:
Mutagen
Reproductive Effector

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