The Registry of Toxic Effects of Chemical Substances

Iron (III) oxide

RTECS #: NO7400000

CAS #: 1309-37-1

UPDATE: May 2005 MW: 159.70 MF: Fe2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 11554 Red
  2. Anchred standard
  3. Anhydrous iron oxide
  4. Anhydrous oxide of iron
  5. Armenian bole
  6. Bauxite residue
  7. Black oxide of iron
  8. Blended red oxides of iron
  9. Burnt umber
  10. Burntisland Red
  11. C.I. 77491
  12. C.I. Pigment Red 101
  13. C.I. Pigment Red 101 and 102
  14. C.I. Pigment Red 102
  15. Calcotone Red
  16. Caput mortuum
  17. Colcothar
  18. Colloidal ferric oxide
  19. Crocus martis adstringens
  20. Deanox
  21. Deanox DNX Pigments
  22. Eisenoxyd
  23. English Red
  24. Ferric oxide
  25. Ferric oxide (colloidal)
  26. Ferrugo
  27. Iron Oxide Red
  28. Iron Red
  29. Iron oxide (ACGIH)
  30. Iron oxide pigments
  31. Iron sesquioxide
  1. Jeweler's rouge
  2. Levanox Red 130A
  3. Light Red
  4. Manufactured iron oxides
  5. Mars Brown
  6. Mars Red
  7. Natural Red Oxide
  8. Natural iron oxides
  9. Ochre
  10. Prussian Brown
  11. Quick rouge
  12. Raddle
  13. Red Iron Oxide
  14. Red ochre
  15. Red oxide
  16. Red oxide D3452
  17. Red oxide D6984
  18. Red oxide of iron
  19. Rouge
  20. Rouge (ACGIH:OSHA)
  21. Rubigo
  22. Sienna
  23. Specular iron
  24. Stone Red
  25. Supra
  26. Synthetic iron oxide
  27. Venetian Red
  28. Vitriol Red
  29. Vogel's Iron Red
  30. Yellow ferric oxide
  31. Yellow oxide of iron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 135 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PBPHAW 14,47,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
rat 		lowest published toxic dose: 250 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		VCVN5* -,431,1989
intratracheal
rat 		lowest published toxic dose: 12 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOLED5 143,223,2003
subcutaneous
dog 		lowest published lethal dose: 30 mg/kg N/R HBAMAK 4,1289,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 µg/m3/24 hour/61 day- continuous Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 50(7),73,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg(Fe)/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 (E) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal NO EVIDENCE IMEMDT 1,29,1972
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 1,29,1972
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,216,1987
TOXICOLOGY REVIEW
ZKKOBW 78,99,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES DTLWS* 3,27,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 3 ppm (5 mg/m3) (fume), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3 (fume), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 6 mg/m3 (dust), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 3.5 mg(Fe)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (fume), JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3 (fume), JAN1999
Occupational Exposure Limit - GERMANY MAK 6 mg/m3 (fume), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg(Fe)/m3, 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 mg/m3 (fume), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) fume 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 3.5 mg/m3 (fume), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 6 mg/m3) (fume), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 10 mg/m3 (fume), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 10 mg/m3 (fume), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg(Fe)/m3, short term exposure limit 10 mg(Fe)/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, rouge, total inhalable dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 4 mg/m3, rouge, respirable dust, sep2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IRON OXIDE, dust and fume (as Fe)-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1463;
Number of Industries 265;
Total Number of Facilities 41,132;
Number of Occupations 153;
Total Number of Employees Exposed 483,117
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1463;
Number of Industries 308;
Total Number of Facilities 62,557;
Number of Occupations 185;
Total Number of Employees Exposed 965,275;
Total Number of Female Employees Exposed 139,397


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as pigment, polishing agent, catalyst, and for iron work
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.

Used as pigment, polishing agent, catalyst, and for iron work

NIOSH PROFILE (IRON AND ITS COMPOUNDS), SRC, 3/82

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen

ALT CAS #: 8011-97-0
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