The Registry of Toxic Effects of Chemical Substances

Isooctyl alcohol

RTECS #: NS7700000

CAS #: 26952-21-6

UPDATE: November 2004 MW: 130.26 MF: C8H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Exxal 8
  2. Isooctanol
  1. Isooctyl alcohol (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe AIHAAP 34,493,1973
skin
rabbit 		2,600 mg/24 hour moderate AIHAAP 34,493,1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 140 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 1,670 mg/kg N/R 85GMAT -,77,1982
oral
rat 		lethal dose (50 percent kill): 1,480 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 34,493,1973
skin
rabbit 		lethal dose (50 percent kill): 2,520 mg/kg N/R 31ZTAS -,72,1968
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,670 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,500 µg/m3/24 hour/96 day- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 37(8),16,1972
inhalation
rat 		lowest published toxic concentration: 600 mg/m3/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0570889


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (270 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (266 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (270 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (270 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (135 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (270 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 270 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOOCTYL ALCOHOL-air 10 hour time-weighted average 50 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83573;
Number of Industries 6;
Total Number of Facilities 160;
Number of Occupations 19;
Total Number of Employees Exposed 32,085
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83573;
Number of Industries 17;
Total Number of Facilities 752;
Number of Occupations 22;
Total Number of Employees Exposed 12,363;
Total Number of Female Employees Exposed 3,300


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
31ZTAS "Alcohols: Their Chemistry, Properties and Manufacture," Monick, J.A., New York, Reinhold Book, 1968
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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