The Registry of Toxic Effects of Chemical Substances

Kerosene

RTECS #: OA5500000

CAS #: 8008-20-6

UPDATE: November 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Coal oil
  2. Deobase
  3. Fuel oil No.5
  4. Kerosine
  1. Kerosine (petroleum)
  2. Nafta (Polish)
  3. Straight - run kerosene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg severe ATDAEI 1,30,1990
skin
rabbit 		1,00%/24 hour moderate VCVPS* -,61,1998


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 25 µL/plate (+enzymatic activation step) CBTOE2 2,63,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 2,500 mg/m3/2 hour N/R VCVPS* -,59,1998
inhalation
dog 		lowest published toxic concentration: 2,500 mg/m3/2 hour Behavioral: Tremor

Behavioral: Alteration of classical conditioning 		VCVPS* -,59,1998
inhalation
rat 		lethal concentration : >5 gm/m3/4 hour Behavioral: Somnolence (general depressed activity) ATDAEI 1,30,1990
intraperitoneal
rat 		lowest published lethal dose: 10,700 mg/kg N/R TXAPA9 1,156,1959
intraperitoneal
rabbit 		lethal dose (50 percent kill): 6,600 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		AIMEAS 21,803,1944
intratracheal
dog 		lowest published lethal dose: 800 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema 		AJMSA9 221,531,1951
intratracheal
rat 		lethal dose (50 percent kill): 800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		TXAPA9 1,462,1959
intratracheal
rabbit 		lethal dose (50 percent kill): 200 mg/kg N/R TXAPA9 3,689,1961
intravenous
dog 		lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema 		AJMSA9 221,531,1951
intravenous
man 		lowest published toxic dose: 403 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Hallucinations, distorted perceptions 		CTOXAO 10,283,1977
intravenous
rabbit 		lethal dose (50 percent kill): 180 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Tremor

Behavioral: Coma 		AIMEAS 21,803,1944
oral
dog 		lowest published lethal dose: 4 gm/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema 		AJMSA9 221,531,1951
oral
domestic animal 		lowest published toxic dose: 10 mL/kg Behavioral: Muscle weakness

Gastrointestinal: Decreased motility or constipation

Nutritional and Gross Metabolic: Body temperature increase 		VHTODE 42,354,2000
oral
domestic animal 		lowest published toxic dose: 20 mL/kg Cardiac: Change in rate

Lung, Thorax, or Respiration: Cough 		VHTODE 42,354,2000
oral
guinea pig 		lethal dose (50 percent kill): 20 gm/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hypoglycemia 		AIMEAS 21,803,1944
oral
human 		lowest published toxic concentration: 5.7 mg/kg N/R VCVPS* -,60,1998
oral
human 		lowest published toxic concentration: 5.7 mg/kg Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting 		VCVPS* -,60,1998
oral
man 		lowest published toxic dose: 3,570 mg/kg Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase 		TORAAK 15,263,1966
oral
man 		lowest published lethal dose: 500 mg/kg N/R YAKUD5 22,883,1980
oral
rat 		lethal dose : >5 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		ATDAEI 1,30,1990
oral
rat 		lethal dose (50 percent kill): 15 gm/kg Skin: After topical application: Corrosive VCVPS* -,59,1998
oral
rabbit 		lethal dose (50 percent kill): 2,835 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hypoglycemia 		AIMEAS 21,803,1944
subcutaneous
rat 		lowest published toxic concentration: 5 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		VCVPS* -,60,1998
skin
rabbit 		lethal dose : >2 gm/kg N/R ATDAEI 1,30,1990
unreported route
man 		lowest published lethal dose: 1,176 mg/kg N/R 85DCAI 2,73,1970
unreported route
rat 		lowest published lethal dose: 2 mg/kg Gastrointestinal: Peritonitis VCVPS* -,60,1998
unreported route
rat 		lowest published toxic concentration: 2 mg/kg Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting 		VCVPS* -,60,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count 		VCVPS* -,60,1998
inhalation
guinea pig 		lowest published toxic concentration: 20,400 mg/m3/21 day- intermittent Vascular: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		VCVPS* -,60,1998
inhalation
human 		lowest published toxic concentration: 250 mg/m3/4 year- intermittent Behavioral: Excitement

Behavioral: Irritability 		VCVPS* -,61,1998
inhalation
human 		lowest published toxic concentration: 0.15 mg/m3/5 year- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) VCVPS* -,61,1998
inhalation
mouse 		lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count 		VCVPS* -,60,1998
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count 		VCVPS* -,60,1998
inhalation
rat 		lowest published toxic concentration: 300 mg/m3/12 week- intermittent Blood: Normocytic anemia

Blood: Luekopenia 		VCVPS* -,61,1998
inhalation
rabbit 		lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count 		VCVPS* -,60,1998
inhalation
rabbit 		lowest published toxic concentration: 300 mg/m3/12 week- intermittent Blood: Normocytic anemia

Blood: Luekopenia 		VCVPS* -,61,1998
oral
rat 		lowest published toxic dose: 540 gm/kg/90 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Endocrine: Antidiuresis 		BCTKAG 21,187,1988
oral
rat 		lowest published toxic dose: 405 gm/kg/17 week- intermittent Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair 		VCVPS* -,61,1998
subcutaneous
rat 		lowest published toxic dose: 84 gm/kg/35 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		ENVRAL 35,516,1984
subcutaneous
rat 		lowest published toxic dose: 11.9 gm/kg/35 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Liver: Multiple effects 		VCVPS* -,61,1998
skin
rabbit 		lowest published toxic dose: 4,500 mg/kg/3 week- intermittent Blood: Pigmented or nucleated red blood cells

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0533973
skin
rabbit 		lowest published toxic dose: 2,400 mg/kg/28 day- intermittent Endocrine: Changes in spleen weight

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair 		NTIS** OTS0541008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 45,39,1989
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,225,1998
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KEROSENE-air 10 hour time-weighted average 100 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1768;
Number of Industries 321;
Total Number of Facilities 69,564;
Number of Occupations 186;
Total Number of Employees Exposed 1,075,728;
Total Number of Female Employees Exposed 96,255
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6889;
Number of Industries 1;
Total Number of Facilities 22;
Number of Occupations 3;
Total Number of Employees Exposed 790


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264222/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8968
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthas, 1550


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TORAAK El Torax. (Montevideo, Uruguay) V.1- 1952-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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