The Registry of Toxic Effects of Chemical Substances

Lactic acid, butyl ester

RTECS #: OD4025000

CAS #: 138-22-7

UPDATE: November 2004 MW: 146.21 MF: C7H14O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Butyl 2 - hydroxypropanoate
  2. Butyl alpha - hydroxypropionate
  3. Butyl lactate
  4. Butylester kyseliny mlecne (Czech)
  1. Propanoic acid, 2 - hydroxy - , butyl ester (9CI)
  2. n - Butyl lactate
  3. n - Butyl lactate (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,727,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >5.14 gm/m3/4 hour N/R FEREAC 67,56225,2002
oral
rat 		lethal dose (50 percent kill): >2,000 mg/kg N/R FEREAC 67,56225,2002
oral
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R IJTOFN 17(Suppl 1),71,1998
subcutaneous
mouse 		lowest published lethal dose: 11 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		FCTXAV 17,727,1979
subcutaneous
rat 		lethal dose (50 percent kill): 12 gm/kg N/R NPIRI* 1,15,1974
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,727,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (5 mg/m3) DTLVS* 3,33,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (30 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (6 mg/m3), short term exposure limit 3 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL LACTATE-air 10 hour time-weighted average 5 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1128;
Number of Industries 8;
Total Number of Facilities 242;
Number of Occupations 10;
Total Number of Employees Exposed 3,107
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1128;
Number of Industries 9;
Total Number of Facilities 170;
Number of Occupations 15;
Total Number of Employees Exposed 5,342;
Total Number of Female Employees Exposed 1,381


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)

RTECS Compound Description:
   Primary Irritant

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