The Registry of Toxic Effects of Chemical Substances

Lactonitrile, 2 - methyl -

RTECS #: OD9275000

CAS #: 75-86-5

UPDATE: November 2004 MW: 85.12 MF: C4H7NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Acetoncianhidrinei (Romanian)
  2. Acetoncianidrina (Italian)
  3. Acetoncyaanhydrine (Dutch)
  4. Acetoncyanhydrin (German)
  5. Acetonecyanhydrine (French)
  6. Acetone cyanohydrin
  7. Acetone cyanohydrin (ACGIH)
  8. Acetonkyanhydrin (Czech)
  1. Cyanhydrine d'acetone (French)
  2. alpha - Hydroxyisobutyronitrile
  3. 2 - Hydroxy - 2 - methylpropionitrile
  4. 2 - Methyllactonitrile
  5. Propanenitrile, 2 - hydroxy - 2 - methyl -
  6. RCRA waste number P069
  7. USAF RH - 8


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (30 percent kill): 70 mg/m3/2 hour N/R 85GMAT -,15,1982
inhalation
rat 		lowest published lethal concentration: 63 ppm/4 hour N/R AIHAAP 23,95,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 1 mg/kg N/R NTIS** AD277-689
oral
guinea pig 		lethal dose (50 percent kill): 9 mg/kg N/R NTIS** PB214-270
oral
mouse 		lethal dose (50 percent kill): 1,898 µg/kg N/R TOVEFN (1),29,1994
oral
rat 		lethal dose (50 percent kill): 18,650 µg/kg N/R TOVEFN (1),29,1994
oral
rabbit 		lethal dose (50 percent kill): 13,500 µg/kg N/R NTIS** PB214-270
subcutaneous
rat 		lethal dose (50 percent kill): 8,500 µg/kg Blood: Other changes BJIMAG 19,283,1962
skin
guinea pig 		lethal dose (50 percent kill): 150 mg/kg N/R AMIHBC 8,371,1953
skin
rabbit 		lethal dose (50 percent kill): 17 µL/kg N/R AIHAAP 23,95,1962
unreported route
mouse 		lethal dose (50 percent kill): 2,900 µg/kg N/R GISAAA 31(6),8,1966
unreported route
rat 		lethal dose (50 percent kill): 13,300 µg/kg N/R GISAAA 31(6),8,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,634 mg/kg/35 week- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes 		AMPMAR 32,653,1971
unreported route
rat 		lowest published toxic dose: 242 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 31(6),8,1966
unreported route
rabbit 		lowest published toxic dose: 242 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA 31(6),8,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 4.7 ppm(CN) (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - HUNGARY short term exposure limit 0.9 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.9 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3.5 mg/m3, Skin, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE CYANOHYDRIN-air ceiling concentration 1 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3298;
Number of Industries 2;
Total Number of Facilities 45;
Number of Occupations 2;
Total Number of Employees Exposed 1,016;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for production of METHYLMETHACRYLATE, and in pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acetone cyanohydrin, 2506


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used as intermediate for production of METHYLMETHACRYLATE, and in pharmaceuticals

NIOSH PROFILE (NITRILES), SRC, 10/77

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