The Registry of Toxic Effects of Chemical Substances

Lead carbonate

RTECS #: OF9275000

CAS #: 598-63-0

UPDATE: May 2005 MW: 267.20 MF: CO3•Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Cerussete
  2. Dibasic lead carbonate
  3. Carbonic acid, lead (2+) salt (1:1)
  1. Lead (2+) carbonate
  2. Plumbous carbonate
  3. White lead


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 40 gm/kg (16 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		TXAPA9 37,160,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published lethal dose: 1 gm/kg N/R EQSSDX 1,1,1975
oral
human 		lowest published lethal dose: 571 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		IPSTB3 3,93,1976
oral
man 		lowest published toxic dose: 214 mg/kg/4 week Gastrointestinal: Contraction (isolated tissue)

Liver: Jaundice, other or unclassified 		NEJMAG 303,459,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 4,500 mg/kg/90 day- continuous Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 37,160,1976
oral
guinea pig 		lowest published toxic dose: 1,860 mg/kg/6 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Irritability

Nutritional and Gross Metabolic: Changes in: Other metals 		ANPTAL 33,185,1975
oral
mouse 		lowest published toxic dose: 57,600 mg/kg/12 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BECTA6 9,80,1973
oral
rat 		lowest published toxic dose: 27,500 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen 		PHRPA6 56,1610,1941
oral
rat 		lowest published toxic dose: 18,000 mg/kg/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease 		JTPAE7 29,451,2001
oral
rat 		lowest published toxic dose: 32,000 mg/kg/16 day- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTPAE7 29,451,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Pb)/m3; animal carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 1,40,1972
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,325,1980
TOXICOLOGY REVIEW
85DHAX Pb,258,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.15 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.04 mg(Pb)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 ppm (0.01 mg(Pb)/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg(Pb)/m3 (resp. dust), JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 mg(Pb)/m3 (total dust), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg(Pb)/m3;
animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air 10 hour time-weighted average <0.1 mg(Pb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80252;
Number of Industries 78;
Total Number of Facilities 2,919;
Number of Occupations 55;
Total Number of Employees Exposed 48,818
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80252;
Number of Industries 8;
Total Number of Facilities 139;
Number of Occupations 12;
Total Number of Employees Exposed 2,791;
Total Number of Female Employees Exposed 772


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pigment in paints, ceramic glazes, putty and cements
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ANPTAL Acta Neuropathologica. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1961-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a pigment in paints, ceramic glazes, putty and cements

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

 Click Here for Additional Information about RTECS