The Registry of Toxic Effects of Chemical Substances

Mercury (II) oxide

RTECS #: OW8750000

CAS #: 21908-53-2

UPDATE: May 2004 MW: 216.59 MF: HgO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. C.I. 77760
  2. Mercuric oxide
  3. Mercuric oxide, red
  4. Mercuric Oxide, Yellow
  5. Mercury monoxide
  6. Mercury (2+) oxide
  1. Oxyde de mercure (French)
  2. Red mercuric oxide
  3. Red oxide of mercury
  4. Santar
  5. Yellow mercuric oxide
  6. Yellow precipitate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 34 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death APTOD9 19,A126,1980
oral
mouse 		lowest published toxic dose: 225 mg/kg (4-12 day pregnant) Reproductive: Other developmental abnormalities TJADAB 26(1),46A,1982
oral
rat 		lowest published toxic dose: 10,800 µg/kg (5 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear 		PWPSA8 15,52,1972
oral
rat 		lowest published toxic dose: 10,800 µg/kg (19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) PWPSA8 15,52,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published lethal dose: 22 mg/kg N/R NCIUS* PH43-64-886
intraperitoneal
mouse 		lethal dose (50 percent kill): 4,500 µg/kg N/R GTPZAB 25(7),27,1981
oral
mouse 		lethal dose (50 percent kill): 16 mg/kg N/R GTPZAB 25(7),27,1981
oral
rat 		lethal dose (50 percent kill): 18 mg/kg N/R NTIS** PB214-270
skin
rat 		lethal dose (50 percent kill): 315 mg/kg N/R GTPZAB 25(7),27,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg(Hg)/m3 (skin) DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 58,239,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 58,239,1993
TOXICOLOGY REVIEW
SDGTB3 1,177,1971


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg(Hg)/m3 DTLWS* 3,22,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.1 mg(Hg)/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.02 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Hg)/m3, MAC(short term exposure limit) 0.15 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.01 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND short term exposure limit 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.05 mg(Hg)/m3, short term exposure limit 0.15 mg(Hg)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-air ceiling concentration 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80143;
Number of Industries 9;
Total Number of Facilities 654;
Number of Occupations 10;
Total Number of Employees Exposed 3,859
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80143;
Number of Industries 10;
Total Number of Facilities 506;
Number of Occupations 27;
Total Number of Employees Exposed 9,517;
Total Number of Female Employees Exposed 3,800


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for wound sealing and canker treatment of fruit and rubber trees
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
SDGTB3 Seminars in Drug Treatment. (New York, NY) V.1-3, 1971-74. Discontinued.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Used for wound sealing and canker treatment of fruit and rubber trees

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector

ALT CAS #: 1344-45-2
ALT CAS #: 8028-34-0
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